TH101413B - Derivatives 4- (3-benzoyl aminophenyl) -6,7-dimethoxy-2-methylaminoquinazoline - Google Patents
Derivatives 4- (3-benzoyl aminophenyl) -6,7-dimethoxy-2-methylaminoquinazolineInfo
- Publication number
- TH101413B TH101413B TH701000756A TH0701000756A TH101413B TH 101413 B TH101413 B TH 101413B TH 701000756 A TH701000756 A TH 701000756A TH 0701000756 A TH0701000756 A TH 0701000756A TH 101413 B TH101413 B TH 101413B
- Authority
- TH
- Thailand
- Prior art keywords
- methylaminoquinazoline
- dimethoxy
- derivatives
- replaced
- formula
- Prior art date
Links
- WIUXQPWOYPYPPR-UHFFFAOYSA-N N-[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]benzamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=CC=C1 WIUXQPWOYPYPPR-UHFFFAOYSA-N 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 239000011780 sodium chloride Substances 0.000 claims abstract 3
- 150000004677 hydrates Chemical class 0.000 claims abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 206010052737 Atopic disease Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
Abstract
สารประกอบที่แทนได้โดยสูตร (I) เกลือของสารดังกล่าว, หรือ ไฮเดรทของสารดังกล่าว, ที่ สามารถบรรเทาอาการคันที่เกิดจากโรคอะโทปิก หรือ ที่คล้ายกันได้อย่างมีประสิทธิภาพ (สูตรคมี) +โดยที่ R แทน ไฮดรอกซิล, C1-6 อัลคอกซีที่ถูกเลือกแทนที่ได้ด้วย C1-5 อัลคอกซี, หรือ อะมิโนที่ถูก เลือกแทนที่ได้ด้วย C1-6 อัลคีล Compounds represented by formula (I) salts of such substances, or hydrates of such substances, that can effectively relieve itching caused by atopic disease or the like (formula Cme). + Where R stands for hydroxyl, C1-6 alkyls can be replaced with C1-5 alkyls, or amino that can be replaced with C1-6 alkyls.
Claims (2)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08711290A EP2123641A4 (en) | 2007-02-16 | 2008-02-14 | Crystal, amorphous form and salt of methyl n-ý3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl¨terephthalamic acid |
PCT/JP2008/052448 WO2008099887A1 (en) | 2007-02-16 | 2008-02-14 | Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid |
CN2008800052028A CN101687818B (en) | 2007-02-19 | 2008-02-14 | Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid |
JP2008558123A JP5102230B2 (en) | 2007-02-16 | 2008-02-14 | Crystal, amorphous or salt of methyl N- [3- (6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid |
KR1020097007623A KR20090118025A (en) | 2007-02-16 | 2008-02-14 | Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid |
AU2008215411A AU2008215411B2 (en) | 2007-02-16 | 2008-02-14 | Crystal, amorphous form and salt of methyl N-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid |
CA002678477A CA2678477A1 (en) | 2007-02-16 | 2008-02-14 | Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid |
US12/032,550 US8530654B2 (en) | 2007-02-16 | 2008-02-15 | Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid |
IL199760A IL199760A0 (en) | 2007-02-16 | 2009-07-08 | Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
TH101413A TH101413A (en) | 2010-05-26 |
TH101413B true TH101413B (en) | 2010-05-26 |
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