TH100673B - Biological utilization of improved antibiotics - Google Patents
Biological utilization of improved antibioticsInfo
- Publication number
- TH100673B TH100673B TH701004469A TH0701004469A TH100673B TH 100673 B TH100673 B TH 100673B TH 701004469 A TH701004469 A TH 701004469A TH 0701004469 A TH0701004469 A TH 0701004469A TH 100673 B TH100673 B TH 100673B
- Authority
- TH
- Thailand
- Prior art keywords
- polymers
- drug
- dissolve
- biological utilization
- water
- Prior art date
Links
- 230000003115 biocidal Effects 0.000 title claims 4
- 239000003242 anti bacterial agent Substances 0.000 title claims 3
- 229940064005 Antibiotic throat preparations Drugs 0.000 title claims 2
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 title claims 2
- 229940042052 Antibiotics for systemic use Drugs 0.000 title claims 2
- 229940042786 Antitubercular Antibiotics Drugs 0.000 title claims 2
- 229940093922 Gynecological Antibiotics Drugs 0.000 title claims 2
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 title claims 2
- 229940079866 intestinal antibiotics Drugs 0.000 title claims 2
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 title claims 2
- 239000003814 drug Substances 0.000 claims abstract 5
- 229940079593 drugs Drugs 0.000 claims abstract 5
- 230000036912 Bioavailability Effects 0.000 claims abstract 3
- 230000035514 bioavailability Effects 0.000 claims abstract 3
- 210000002784 Stomach Anatomy 0.000 claims abstract 2
- 239000006187 pill Substances 0.000 claims abstract 2
- 239000000470 constituent Substances 0.000 claims 2
- 239000002085 irritant Substances 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 2
- 206010011401 Crohn's disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Abstract
วัตถุประสงค์ในการคิดค้นประกอบไปด้วยการเตรียมสูตรทางเภสัชกรรมที่มีริฟฟาชิมินในรูปของเม็ด ยาขนาดเล็กที่ใช้ต้านการระคายเคืองของกระเพาะอาหาร โดยการใช้พอลลิเมอร์ที่ไม่สามารถละลายได้หรือแตก ตัวได้ในน้ำมีค่า pH ระหว่าง 1.5 ถึง 4.0 และสารพอลลิเมอร์ที่สามารถละลายหรือแตกตัวได้ในน้ำที่ค่า pH ระหว่าง 5.0 ถึง 7.5 มีลักษณะที่มีการใช้ประโยชน์ทางชีววิทยาที่สูงกว่า เมื่อเปรียบเทียบสูตรอื่นๆ โดยการ เปรียบเทียบและการใช้ในการผลิตยาที่มีประโยชน์ในการรักษาโรคลำไส้อักเสบ (IBD) และโดยเฉพาะโรคโครห์น หรือโรคลำไส้เล็กอักเสบ The purpose of their invention was to prepare a pharmaceutical formulation containing riffashimin in the form of tablets. Small pills used to fight irritation of the stomach. By using polymers that cannot be dissolved or broken The water-soluble polymers have a pH between 1.5 and 4.0, and the polymers that can dissolve or dissolve in water at pH between 5.0 and 7.5 are characterized by higher bioavailability. When comparing other formulations by comparison and use in the production of drugs that are useful in the treatment of inflammatory bowel disease (IBD) and especially Crohn's disease. Or inflammatory bowel disease
Claims (4)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH100673B true TH100673B (en) | 2010-03-26 |
| TH100673A TH100673A (en) | 2010-03-26 |
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