SU978184A1 - Osteomyelitis simulation method - Google Patents
Osteomyelitis simulation method Download PDFInfo
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- SU978184A1 SU978184A1 SU802886835A SU2886835A SU978184A1 SU 978184 A1 SU978184 A1 SU 978184A1 SU 802886835 A SU802886835 A SU 802886835A SU 2886835 A SU2886835 A SU 2886835A SU 978184 A1 SU978184 A1 SU 978184A1
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- USSR - Soviet Union
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- osteomyelitis
- simulation method
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- modeling
- staphylococcus
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Изобретение относитс к медицине ,j и может быть использовано дл изу- 1 чени патоге;неза остеомиелита и методов профилактики и лечени паталогическрго процесса.The invention relates to medicine, j, and can be used to study the pathogen, non-osteomyelitis, and methods for the prevention and treatment of the pathological process.
Известен способ моделировани остеомиелита путем внутрикостного введени через питающую кость артерию инфицирующей смеси, включающей 10% мелкодисперсной суспензии активированного угл на 2%-ном растворе карбоксиметилцеллюлозы, смешанной с чистой культурой специфического штамма патогенного стафилококка 1.There is a known method for modeling osteomyelitis by intraosseous administration through an artery feeding bone of an infectious mixture comprising 10% finely dispersed activated carbon suspension in a 2% carboxymethylcellulose solution mixed with a pure culture of a specific strain of pathogenic staphylococcus 1.
Однако известный способ моделировани не патофизиологичен и не пригоден дл разработки патогенетических методов профилактики и лечени из-за использовани чужеродных дл организма, трудноудал емых веществ, воспроизводит только т желые формы тотального остеомиелита; недостаток способа также - трудность воспроизведени модели за счет использовани специфического штамма золотистого стафилококка, специального оборудовани и подготовки экспериментатора , невозможность регул ции т жести повреждени и воспроизводимости различных клинических форм патологии.IHowever, the known method of modeling is not pathophysiological and not suitable for the development of pathogenetic methods of prevention and treatment due to the use of foreign to the body, difficult to remove substances, reproduces only severe forms of total osteomyelitis; The disadvantage of the method is also the difficulty of reproducing the model due to the use of a specific strain of Staphylococcus aureus, special equipment and the preparation of the experimenter, the impossibility of regulating the severity of damage and reproducibility of various clinical forms of pathology.
Цель изобретени - повышение воспроизводимости модели.The purpose of the invention is to increase the reproducibility of the model.
Поставленна цель достигаетс тем, что согласно способу моделировани остеомиелита путем внутрикостного введени инфицирующей смеси , транскортикально одноразово The goal is achieved by the fact that according to the method of modeling osteomyelitis by intraosseous administration of an infectious mixture, transcortically once
10 ввод т раствор тромбопластина в дозе 0,2-0,3 мл активностью 10-25 с, содержащий 2-3 млн микробных тел плазмокоагулирующего стафилококка.10, a thromboplastin solution is administered in a dose of 0.2-0.3 ml with an activity of 10-25 s, containing 2-3 million microbial cells of plasma-coagulating staphylococcus.
Способ осуществл етс следуюьим The method is carried out as follows.
15 образом.15 way.
Через м гкие ткани иглой Кассирского транскортикально ввод т 0,2-0,3 мл раствора тромбопластина активностью 10-25 с, содержащего Through soft tissues, a 0.2–0.3 ml thromboplastin solution with an activity of 10–25 s, containing
20 2-3 млн микробных тел суточной .культуры стафилококка, обладающего высокой плазмокоагулирующей способностью .20 2-3 million microbial bodies of the daily culture of staphylococcus with high plasma-coagulating ability.
Медленное введение раствора (в 25 течение 30-40 с )приводит к развитию остеомиелитическо1;о процесса у животных при низкой летальности ( менее 5% ), обеспечивает очаговое или тотальное поражение кости, при Slow administration of the solution (in 25 for 30–40 s) leads to the development of osteomyelitis1; about the process in animals with a low lethality (less than 5%), provides focal or total bone damage, with
30 зтом степень т жести ;патологического30 this degree of severity; pathological
процесса регулируетс за счет использовани различной активности тромбогшастина. Введение раствора тромбопластина активностью 10-17.с воспроизводит очаговый местный остемиелит , введение тромбопластина ак тивностьго 18-25 с - распространенны тотальный остеомиелит.The process is regulated by using different thrombogshastin activity. The introduction of a thromboplastin solution with an activity of 10-17.c reproduces focal local osteomyelitis, the administration of thromboplastin activity is 18-25 s - total osteomyelitis is common.
Использование естественного тканевого фермента, тромбрпластина и ограничение патологического процесса в месте введени на начальных этапах моделировани повышает воспроизводимость процесса, позвол ет регулировать т жесть поражени и получение различных клинических форм, делает данную модель пригод- ; ной дл разработки патогенетических методов профилактики и раннего лечени остеомиелита.The use of a natural tissue enzyme, thrombplastin and limiting the pathological process at the site of introduction in the initial stages of modeling increases the reproducibility of the process, allows you to adjust the severity of the lesion and the production of various clinical forms, makes this model suitable; development of pathogenetic methods for the prevention and early treatment of osteomyelitis.
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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SU802886835A SU978184A1 (en) | 1980-02-22 | 1980-02-22 | Osteomyelitis simulation method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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SU802886835A SU978184A1 (en) | 1980-02-22 | 1980-02-22 | Osteomyelitis simulation method |
Publications (1)
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SU978184A1 true SU978184A1 (en) | 1982-11-30 |
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SU802886835A SU978184A1 (en) | 1980-02-22 | 1980-02-22 | Osteomyelitis simulation method |
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SU (1) | SU978184A1 (en) |
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1980
- 1980-02-22 SU SU802886835A patent/SU978184A1/en active
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