SU97249A1 - Method for producing alpha-hydroxy-beta-cyano-isonicotinic acid amide derivatives - Google Patents
Method for producing alpha-hydroxy-beta-cyano-isonicotinic acid amide derivativesInfo
- Publication number
- SU97249A1 SU97249A1 SU446916-??A SU446915A SU97249A1 SU 97249 A1 SU97249 A1 SU 97249A1 SU 446915 A SU446915 A SU 446915A SU 97249 A1 SU97249 A1 SU 97249A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- cyano
- hydroxy
- amide derivatives
- beta
- isonicotinic acid
- Prior art date
Links
Landscapes
- Pyridine Compounds (AREA)
Description
Известен способ получени производных амида к-окси-З-циан-изоникотиновой кислоты путем конденсации дикетокарбоновых эфиров с цианацетамидом. Процесс ведетс в две стадии.A known method for the preparation of amide derivatives of c-hydroxy-3-cyano-isonicotinic acid by condensation of diketocarboxylic esters with cyanacetamide. The process is conducted in two stages.
Предлагаемый способ позвол ет осуществл ть синтез производных амида а-окси-3-циан-изоникотиновой кислоты в одну стадию, так как исключает необходимость получени промежуточного продукта , 7-Дикетокарбоновой кислоты.The proposed method allows the synthesis of a-hydroxy-3-cyano-isonicotinic acid amide derivatives in a single step, since it eliminates the need to produce an intermediate, 7-dikethocarboxylic acid.
Особенность предлагаемого способа заключаетс в том, что конденсацию провод т в водном растворе аммиака.A feature of the proposed method is that the condensation is carried out in an aqueous solution of ammonia.
Пример. 0,84 г цианацетамида и 1,44 г метилового эфира ацетилпировиноградной кислоты взбалтывают с 8 мл 25%-ного водного раствора аммиака до полного растворени Example. 0.84 g of cyanacetamide and 1.44 g of acetylpyruvic acid methyl ester are agitated with 8 ml of 25% aqueous ammonia solution until complete dissolution
(3-5 мин.). Происходит постепенное разогревание смеси до температуры Через некоторое врем начинаетс выделение осадка, которое продолжаетс 3-5 дней.(3-5 min.) A gradual warming up of the mixture to a temperature occurs. After some time, precipitation begins, which lasts for 3-5 days.
Осадок отфильтровывают и нагревают с 80%-ной уксусной кислотой , затем отфильтровывают и после сушки получают 1,3 г (73% от теории ) амида 3-циан-4-карбокси-6-метил-2-пиридона , имеющего температуру плавлени выше 320°.The precipitate is filtered off and heated with 80% acetic acid, then filtered and after drying, 1.3 g (73% of theory) of 3-cyan-4-carboxy-6-methyl-2-pyridone amide having a melting point of over 320 are obtained °
Предмет изобретени Subject invention
Способ получени производных амида а-окси-3-циан-изоникотиновой кислоты путем конденсации дикетокарбоновых эфиров с цианацетамидом , отличающийс тем, что, с целью проведени процесса в одну стадию, конденсацию провод т в водном растворе аммиака.The method of producing amide derivatives of a-hydroxy-3-cyano-isonicotinic acid by condensation of diketocarboxylic esters with cyanacetamide, characterized in that, in order to carry out the process in one step, condensation is carried out in aqueous ammonia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU446916-??A SU97249A1 (en) | 1953-07-02 | 1953-07-02 | Method for producing alpha-hydroxy-beta-cyano-isonicotinic acid amide derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU446916-??A SU97249A1 (en) | 1953-07-02 | 1953-07-02 | Method for producing alpha-hydroxy-beta-cyano-isonicotinic acid amide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU97249A1 true SU97249A1 (en) | 1953-11-30 |
Family
ID=48371896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU446916-??A SU97249A1 (en) | 1953-07-02 | 1953-07-02 | Method for producing alpha-hydroxy-beta-cyano-isonicotinic acid amide derivatives |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU97249A1 (en) |
-
1953
- 1953-07-02 SU SU446916-??A patent/SU97249A1/en active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US1895105A (en) | Cubt bath | |
| SU97249A1 (en) | Method for producing alpha-hydroxy-beta-cyano-isonicotinic acid amide derivatives | |
| US2924599A (en) | Derivatives of 1:3:5-triazanaphthalene | |
| SU133886A1 (en) | Method for preparing 4-amino-2,4-dimethyl-delta-2-tetrahydro-6-pyridone-4-carboxyl amide | |
| SU539034A1 (en) | The method of obtaining 2,3,5,6-tetrachloropyridine | |
| US2548173A (en) | Process of making 5-nitro-2-furaldehyde semicarbazone | |
| SU122751A1 (en) | Method for preparing 4-alkyl- and 4-arylaminoquinolines | |
| SU99211A1 (en) | The method of producing dehydro-androsterone acetate from its semicarbazone | |
| US1490020A (en) | Process of preparation of soluble derivatives of dioxyarsenoanilin | |
| SU148387A1 (en) | Method for producing trichlorophosphazoacyls | |
| SU69938A1 (en) | The method of obtaining nicotinic acid | |
| SU1539A1 (en) | Method for preparing 2,7-diamido derivatives of xanthone or its homologs | |
| SU66870A1 (en) | The method of obtaining 2-acyl-methylene-3-alkyl-benzthiazolines | |
| SU659082A3 (en) | Method of obtaining p-acetamidophenol diethylaminoacetate or its chlorine hydrate salt | |
| SU457218A3 (en) | The method of obtaining derivatives of aminoquinoline | |
| SU97532A1 (en) | The method of producing dehydroandrosterone acetate | |
| SU392066A1 (en) | Method of producing isopropylhydrazide 4,6-diphenylpyrimidine-2-carboxylic acid or | |
| SU379575A1 (en) | METHOD OF OBTAINING 2-ACETYLAMINO-5-NITROTHIAZOLE | |
| SU431161A1 (en) | METHOD OF OBTAINING TIOCHOLINE | |
| SU150793A1 (en) | Method for producing alkoxymethylene amides of 0,0-dialkylthio and 0,0-dialkyl dithiophosphoryl acetic acid | |
| SU136378A1 (en) | Method for preparing 2-acetylaminothiazole | |
| SU574445A1 (en) | Method of preparing 5-nitrobenzofurazan | |
| SU120515A1 (en) | Method for producing bis (1,4-thiazan-S-dioxide) -N1 N1-diethyl sulfone | |
| US2153016A (en) | Pyrimidine compounds | |
| SU405879A1 (en) | METHOD OF OBTAINING N-ARYLSULPHONILARENIMINO-SELENINE ACID CHLORANGIDRIDES |