SU946545A1 - Method of recovery of potassium difficit in tissues - Google Patents

Description

(54) METHOD FOR FILLING POTASSIUM DEFICIENCY The invention relates to clinical medicine for the treatment of diseases whose pathogenesis is, in particular, potassium deficiency in tissue and cell acidosis (for example, hypertensive disease, ischemic heart disease, cardiosclerosis, diabetes mellitus, Diseases of the gastrointestinal tract, glomerulonephritis, pyelonephritis, postoperative conditions after abdominal operations, peritonitis, pancreatitis, shock. There is a known method of filling up the potassium deficiency in tissues and sodium However, due to low potassium uptake, the known method does not provide rapid normalization of potassium deficiency replenishment. The purpose of the invention is to accelerate the normalization of potassium deficiency replenishment. The goal is achieved by implementing the method of potassium deficiency in tissues by administering to the body salts of potassium and sodium as salts are introduced a mixture of a 1% aqueous solution of potassium gnlcarbonate or a 4% solution of bicarbonate in sodium into tissues and a 2% solution of potassium chloride in an amount of 200-250 ml per injection for 3-4 weeks. The method is carried out as follows. Example. 200-250 ml of a 1% aqueous solution of potassium bicarbonate every 2 and 3 days for 3–4 weeks or 150–200 ml of 4% sodium bicarbonate solution are administered once a day to the patient in a lying position. and 50-65 ml of 2% potassium chloride solution every 2nd and 3rd day, depending on the clinical condition. With a more severe clinical condition of the patient, administration is performed every other day, with moderate illness, every third day. The injected drugs do not exclude each other .1-UPDATE. When intravenously injected into the body 200-250 ml of a 1% solution of potassium bicarbonate of a chemical compound with the same basic properties, the reduction or elimination of potassium deficiency in tissues is achieved due to the influx of potassium ions into food cells, in the composition of the drug. The administration of large doses of potassium bicarbonate can cause short-term hyperkalemia, a decrease in dose has an insufficient therapeutic effect. When intravenously administered with 150-200 ml, 4% aqueous solution of sodium bicarbonate and 50 60 ml of 2% aqueous potassium chloride, chemical compound with poorly expressed basic properties, in one solution with sodium bicarbonate, the reduction or elimination of potassium deficiency in tissues is also achieved due to the entry of potassium ions into cells from food products comrade and potassium ions entering the composition of the drug. The proposed chemical compounds are effective because they do not cause adverse pathological effects in the body and contain potassium ions in their composition. An aqueous solution containing sodium tilcarbonate and potassium chloride is obtained by simple displacement before injection of a 4% aqueous solution of sodium hydrogencarbonate and a 2% aqueous solution of potassium chloride. The following doses are recommended: sodium hydrocarbonate 150-200 ml of 4% aqueous solution and potassium chloride 50-65 ml of 2% aqueous solution. The amount of chloride, potassium in the resulting solution should not exceed 0.5% of the concentration in the total solution. An increase in the dose of sodium bicarbonate and potassium chloride can lead to short-term hyperkalemia, and a decrease in dose gives insufficient therapeutic effect. The proposed method was tested in the clinic for 70 patients with hypertensive disease, coronary heart disease and chronic glomerulonephritis. The basis of pittogenesis Dynamics of electrolyte metabolism under the influence of potassium bicarbonate in patients with ischemic heart disease (and 23). of these diseases, in particular, potassium deficiency in tissues lies. As a result of the introduction of potassium bicarbonate, potassium uptake increases. This is confirmed by the clinical effect and dynamics of the exchange of potassium, sodium and calcium in daily urine, erythrocytes and serum in patients with coronary heart disease with a partial heart rate and heart rhythm disturbance. See Table 1 and 2 When using sodium bicarbonate and potassium chloride in in one solution, potassium uptake is high. This is confirmed by the clinical effect and dynamics of serum potassium, sodium and bromine, the dynamics of renal excretion; potassium, sodium, chlorine (Table 3-5 b) As can be seen from the tables, after the introduction of 150 ml of 4% NaHCO solution and 50 ml of 2 i-Horo KSE solution in one solution, the content of potassium and sodium in serum does not change, bromine concentration increases. Potassium excretion by potassium does not increase, while with KCf administered on glucose or isotonic sodium chloride, the potassium uptake is low and the kidneys are released up to 50% of potassium ions incorporated into potassium chloride. immediately after administration of KSe and NaHCO-j in the same solution while The potassium content and the unchanged potassium production show that potassium ions in the tissue are supplied with water molecules, which leads to an increase in serum bromine concentration. Thus, the proposed method allows the body to increase potassium uptake by binding excess hydrogen ions in cells and extracellular liquids, which provides an earlier and lasting therapeutic effect in the absence of adverse negative effects, Table 1

After leche4, 1 ± .1,83 ± 0,444-Н nor fO, 2 + 0.03 + 0.15 0.5 0.050.05

17.3+ 1G, 0 + +0.2 +0.02

0.50.5 36.7+ 327-4-ЗТ7 + +1.1 + 2.0 + 2.4 0.01 0.050.01 5 Dynamics of electrolyte exchange under impaired

After leche

. ,,. Table3

The content of potassium, sodium (in meq / l) and bromine (c) in the serum of patients with iA hypertension and B stages before and after the administration of solutions containing potassium chloride and sodium bicarbonate ().

Note "1 sample was taken immediately before the solution was injected;

2 sample. - one hour after the introduction of the solution; 3 sample attic day after injection of the solution; 4-6 samples in the same time period before and after the 3rd injection of the solution; confidence intervals are given at, 05; for bromine, there are oscillations of goelles (A).

Daily kidney excretion of potassium, sodium, chlorine (in meq) in patients with hypertensive disease 1L and B stages before and after the internal administration of solutions containing potassium chloride and sodium bicarbonate (.).

drug administration, reliable values (, 05) are underlined.

Table 4 9465456 Table effect of potassium bicarbonate in patients with heart rhythm (). Diurnal and diuresis

Background Data Remarks

Claims (1)

Claims of the method of potassium deficiency replenishment in tissues by introducing potassium and sodium salts into the organism, characterized in that, in order to accelerate the normalization of potassium deficiency, a mixture of 1% aqueous solution of potassium bicarbonate or 4% is added as salts solution of bicarbonate natPri introduction HSE + NaHCOj and 2% potassium chloride solution in the amount of 200-250 ml per injection for 3-4 weeks. Sources of information taken into account during the examination 1. Barnatsky V.N. and others. Comparative assessment of the toxicity of potassium bicarbonate and potassium chloride. Pharmacologists and toxicologists, 1976., №2, p.230. kidney excretion of potassium, sodium, calcium, bicarbonates (in meq (in ml in patients with chronic g of omeruronephritis before and after internal administrations of KCg and NaHCOi, () The arrows indicate the days on which the CS and NaHCO were administered, the confidence intervals are given at, 05, Table 5