SU935106A1 - Method of increasing narcotic activity - Google Patents

Description

The invention relates to medicine, in particular to surgery and anesthesiology.

There is a method of increasing the effect of narcotic drugs by prior administration of drugs into the body [1].

However, most drugs possess toxic effects in the form of oppression of the respiratory and vasomotor centers. <

The aim of the invention is to reduce the toxic effects of drugs.

This goal is achieved by the fact that the method of increasing the effect of narcotic drugs is carried out by preliminary administration of drugs, as a medicine use a 0.01% aqueous solution of nicotinic acid, which is administered intramuscularly at a dose of 2.0-

2.5 mg / kg in 45-60 minutes.

The proposed method consists in the fact that experimental animals — white rats — are injected intramuscularly with nicotinic acid in the form of a 0.01% aqueous solution in a dose of 2.0-2.5 to reduce the side effects of drugs, lengthen the drug period and reduce the dose of the drug. mg / kg body weight 45-60 minutes before the use of a narcotic substance (hexenal).

The experiments were conducted on 16 groups of white outbred rats weighing 120 + 5 g, 10 animals in each group.

Group 1 rats were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at a rate of 1 mg / kg body weight once 45 minutes before the intraperitoneal injection of the drug (hexenal at a dose of 60 mg / kg). ''

Animals'2 groups were intramuscularly injected once with a 0.01% aqueous solution of nicotinic acid at a rate of 1.5 mg / kg body weight 45 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg.

Group 3 rats were intramuscularly administered once, 45 minutes before the intraperitoneal administration of hexenal at a dose of 5 to 60 mg / kg, a 0.01% aqueous solution of nicotinic acid at a rate of 2.0 mg / kg body weight.

Group 4 rats were intramuscularly injected with a 0.01% aqueous solution of nicotine new acid at a rate of 2.5 mg / kg body weight, once 45 minutes before the administration of hexenal, a dose of 60 mg / kg.

Animals of group 5 intramuscularly. . 5, a 0.01% aqueous solution of nicotinic acid was administered once at a rate of 3.0 mg / kg body 45 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg. 20

Rats of group 6 were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at a rate of 1.0 mg / kg body weight, once 60 minutes before the intraperitoneal administration of hexenal 25 at a dose of 60 mg / kg.

Group 7 rats were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at a rate of 1.5 mg / kg 5® body weight, once 60 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg.

Group 8 animals were intramuscularly injected with a 0.01% aqueous solution of niacin 35 at the rate of мг 2 mg / kg body weight, once 60 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg.

Group 9 rats were injected intramuscularly, once 60 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg, a 0.01% aqueous solution of nicotinic acid at the rate of

2.5 mg / kg body weight. 45

Rats of group 10 were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at the rate of 3 mg / kg body weight, once 60 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg.

Animals of group 11 were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at a rate of 2.5 mg / kg body weight, once 30 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg.

Rats of group 12 were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at a rate of 2.5 mg / kg body weight, once 90 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg.

Rats of group 13 were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at the rate of ^ 5 mg / kg body weight, once 120 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg.

Animals of the 14th group were injected intramuscularly with a 0.025% aqueous solution of chlorpromazine at a rate of 5 mg / kg body weight, once 60 minutes before the intraperitoneal injection of hexenal at a dose of 60 mg / kg. Rat group 15 was injected intramuscularly with a 0.01% aqueous solution of nicotinic acid based on 2.5 mg / kg body weight.

Group 16 rats were intraperitoneally injected with hexenal at a dose of 60 mg / kg body weight.

The results of experimental studies are shown in the table.

As can be seen from the table, the proposed method revealed the optimal dosage of nicotinic acid - 2.0-2.5 mg / kg and the optimal duration of its administration 45-60 minutes before drug use.

The introduction of nicotinic acid before the use of narcotic drugs (hexenal) reduces the dose of the drug by 25% and thereby reduces the toxic effect on the animal's body, extends the duration of the drug period by 2.3 times, while the preliminary administration of chlorpromazine increases the duration of hexenal sleep only by 1 , 1 time.

Dead body- The dose is not Dose Dose Time on Duration pa kurtino amine hex Dénia Heck hexenal sleep, stomach- howling kitty zina Nala senala min ny lots, mg / kg mg / kg mg / kg min

1,0, 5

60.0 45

60.0 45

28.4 + 2.3

37.7 ± 4.3

935X6 4

Group of animals Dose of nicotinic acid, mg / kg The dose of chlorpromazine, mg / kg Hexenal dose, mg / kg Hexenal administration time The duration of hexenal sleep, min 3 2.0 - 60.0 45 41.2 ± 1.8 4 2,5 - 60.0 45 47.0 ± 0.9 5 3.0 - 60.0 45 28.2 + 1.8 6 1,0 - 60.0 60 32.4 + 2.8 7 1,5 - 60.0 60 36.2 + 4.3 8 2.0 - 60.0 60 43.1 ± 1.1 9 2,5 - 60.0 60 48.4 + 4.3 10 3.0 - 60.0 60 26.2 + 1.8 eleven 2,5 - 60.0 thirty 25.8 ± 1.1 12 2,5 - 60.0 90 34.2 ± 3.7 thirteen 2,5 60.0 120 27.2 ± 0.9 14 - 5 60.0 60 23.2 ± 2.5 fifteen- 2,5 - - - Did not sleep 16 - - 60.0 - 21.1 + 2.8

Claims (1)

(3) METHOD OF IMPROVING DRUG ADMINISTRATIONS The invention relates to medicine, namely to surgery and anesthesiology. There is a known method of enhancing the action of narcotic drugs by first injecting drugs into the body. The aim of the invention is to reduce the toxic effect of narcotic drugs. This goal is achieved by the fact that the method of enhancing the effect of narcotic drugs is carried out by pre-administering drugs, 0.01; -aqueous solution of nicotinic acid, which is administered intramuscularly at a dose of 2.02, 5 mg / kg, is used as a drug. for “W-min The proposed method consists in that experimental rats, white rats, in order to reduce the side effects of drugs, lengthen the drug period and reduce the dose of the drug, are given intramuscularly nicotinic acid in the form of a 0.01% aqueous solution at a dose of 2.0-2, 5 mg / kg body weight for 45-60 minutes before using a narcotic substance (hexenal). The experiments were carried out on 16 groups of white outbred rats weighing 120 + 5 g, 10 animals in each group. Rats of group 1 were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at the rate of 1 mg / kg body weight once 5 minutes before intraperitoneal administration of the drug (hexenal at a dose of 60 mg / kg). Group 2 animals were intramuscularly injected once with 0.01, an aqueous solution of nicotinic acid at the rate of 1.5 mg / kg body weight per kS min 93 before intravenous administration of hexenal at a dose of 60 mg / kg. Rats of group 3 were intramuscularly injected once, 5 minutes before intraperitoneal administration of hexenal at a dose of 60 mg / kg, 0, an aqueous solution of nicotinic acid at the rate of 2.0 mg / kg of body weight. Rats of the k group were intramuscularly injected with a 0.01% aqueous solution of nicotine acid at the rate of 2.5 mg / kg body weight, once 45 minutes before the administration of the drug, hexenal, at a dose of 60 mg / kg. Animals of the 5th group were intramuscularly injected once with a 0.01% aqueous solution of nicotinic acid at a rate of 3.0 mg / kg of the body 5 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg. Rats of group 6 were intramuscularly injected with 0, an aqueous solution of nicotinic acid at the rate of 1.0 mg / kg body weight, once 60 minutes before intraperitoneal administration of hexenal at a dose of 60 mg / kg. Rats of group 7 were intramuscularly injected with a 0.01% aqueous solution of nicotine acid at the rate of 1.5 mg / kg body weight, once 60 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg. Animals of group 8 were administered intramuscularly 0, an aqueous solution of nicotinic acid at the rate of 2 mg / kg body weight, once 60 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg. Rats of group 9 were injected intramuscularly, once 60 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg, 0.01 5% aqueous nicotinic acid solution at the rate of 2.5 mg / kg body weight. Rats of group 10 were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid at the rate of 3 mg / kg body weight, once for 60 minutes before 4 intraperitoneal administration of hexenal at a dose of 60 mg / kg. Animals of group 11 were intramuscularly injected with 0, an aqueous solution of nicotinic acid at the rate of 2.5 mg / kg body weight, once 30 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg. Rats of group 12 were intramuscularly injected with 0, an aqueous solution of nicotinic acid at the rate of 2.5 mg / kg body weight, once 90 minutes before intraperitoneal administration of hexenal at a dose of 60 mg / kg. Rats of group 13 were intramuscularly injected with a 0.01% aqueous solution of nicotinic acid based on (2.5 mg / kg body weight, once 120 minutes before intraperitoneal administration of hexenal at a dose of 60 mg / kg. Animals of the 14th group were intramuscularly injected with 0.025 aqueous aminazine solution at the rate of 5 mg / kg body weight, once 60 minutes before the intraperitoneal administration of hexenal at a dose of 60 mg / kg 0.01% aqueous solution of nicotinic acid at the rate of 2.5 mg / kg body weight was intramuscularly injected into rats of the 15th group. Rats of group 16 were intraperitoneally injected with hexenal in a dose of 60 mg / kg of weight. The results of experimental studies are shown in Table 1. As can be seen from the table, the proposed method reveals the optimal dosage of nicotinic acid - 2.0-2.5 mg / kg and the optimal time for its administration 45-60 minutes before the use of the drug. before the use of narcotic drugs (hexenal), reduces the dose of the drug by 25% and thereby reduces the toxic effect on the animal’s body, lengthens the duration of the narcotic period by 2.3 times, while prior administration of aminazine increases the Hexenal sleep duration is only 1.1 times. DETAILED DESCRIPTION OF THE INVENTION Method for enhancing the effect of narcotic drugs by prior administration of drugs, in order to reduce the toxic effect of narcotic drugs, a 0.01% aqueous solution of nicotine ACID is used as a drug, which is administered intramuscularly at a dose of 2 , 0-2.5 mg / kg per min. Sources of information taken into account during the examination 1. Mashkovsky M. D. Medicines, vol. 1, M., Medicine, 1977, p. kk-k5.