SU904713A1

SU904713A1 - Stand for investigating trombogenesis

Info

Publication number: SU904713A1
Application number: SU792849053A
Authority: SU
Inventors: Моисей Абрамович Локшин; Виктор Ильич Копин; Елена Николаевна Кремнева
Original assignee: Предприятие П/Я В-2481
Priority date: 1979-12-06
Filing date: 1979-12-06
Publication date: 1982-02-15

Description

II

Изсзбретение относитс к области медицины, в частности к устройствам дл исследовани крови.Selection refers to the field of medicine, in particular to blood testing devices.

Известен стенд дл исследовани тромбообразовани в системах in vitro , содержащий замкнутый контур циркул ции 1 .A stand for investigating thrombus formation in in vitro systems containing a closed loop 1 is known.

Однако известный стенд не дает возможности проводить сравнительную оценку исскусственных желудочков на тромбообразование.However, the well-known stand does not allow for a comparative assessment of the artificial ventricles for thrombus formation.

Цель предлагаемого изобретени возможность сравнительной оценки искусственных желудочкоп на тромбообразование .The purpose of the invention is the comparative evaluation of an artificial ventricular thrombus formation.

Указанна цель достигаетс тем, что стенд дополнительно снабжен имитатором аорты, выполненным в виде подключенного к ресиверу бесклапанного испусственного желудочка, имитатором периферического сопротивлени и приспособлением дл введени в кровь дестабилизирующего раствора.This goal is achieved by the fact that the stand is additionally equipped with an aortic simulator, made in the form of a valveless ventricle connected to the receiver, a simulator of peripheral resistance and a device for introducing destabilizing solution into the blood.

при этом выход испытуемого искусственного желудочка, посредством последовательно соединенных имитатора аорты, имитатора периферического сопротивлени и приспособлени дл введени в кровь дестабилизирующего раствора соединен с его входом.in this case, the output of the test artificial ventricle, by means of a serially connected aortic simulator, a simulator of peripheral resistance, and a device for introducing a destabilizing solution into the blood, is connected to its entrance.

Приспособление дл введени в кровь дестибилизирующего раствора выполнено в виде шприца.A device for injecting a destibilizing solution into the blood is made in the form of a syringe.

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На чертеже изс ражена схема предлагаемого стенда.The drawing shows the layout of the proposed stand.

Claims

The stand for thrombogenesis contains a closed circulation loop 1, a simulator of the aorta, performed as a valve-less artificial ventricle 3 connected to the receiver 2, a simulator of peripheral resistance, and a device for injecting destabilizing solution into the blood, in the form of a syringe 5 with the outlet nozzle 6 the test artificial ventricle 7 of the heart through a sequentially connected aortic simulator 3, a peripheral resistance simulator k and a syringe 5 connected to the inlet nozzle 8 m, 9 Plevmokamera test ventricle under key K pneumatic drive 10. Stand for studies thrombus operates as follows: The circuit is filled with a stabilized blood. Then, the pneumatic chamber 9 of the artificial ventricle 7 of the heart is connected to the pneumatic actuator 10, and the valve-less artificial ventricle 3.- to the receiver 2 with a given charging pressure. The pressures of the actuator and receiver are monitored using pressure sensors 11 and 12, respectively. During systole, blood from working chamber A of the test artificial ventricle 7 through diaphragm 13 through pipe 6 through a closed circuit pipeline 1 enters the working chamber B of the valveless artificial ventricle 3 (aortic simulator) During this period, the diaphragm 1 of the artificial ventricle 3 moves to the right extreme position. During the diastole period, the blood from the camera G, through the simulator of peripheral resistance, flows through the cutting rod 8 into the working chamber A of the artificial ventricle 7. During this period, the diaphragm moves to the left extreme position. When blood enters chamber A using a syringe 5, blood is introduced into the bloodstream, destabilizing it (solution. Then the cycle repeats. Thrombus formation occurs during operation. The effect of thrombus formation is observed by the amount of movement of the diaphragm I. The larger the three-fold formation, the smaller movement of difaragma 1 4.. 34 The use of the proposed shadow allows the initiation of thrombosis in stabilized blood directly in the artificial ventricle of the heart during blood circulation fishing rods in an in vitro system that reduces the cost of the study, compared with experiments on animals in the hundreds of times. Claim 1. A test stand for thrombosis containing a closed circulation loop, characterized in that, in order to allow a comparative evaluation of the artificial ventricles for thrombosis, it is additionally equipped with an aortic simulator, made in the form of a valve-less artificial ventricle connected to the receiver, and a peripheral resistance simulator a device for the introduction of a destabilizing solution into the blood, while the output of the test artificial ventricle by means of a simulator connected aortic simulator peripheral resistance and means for introducing the blood solution destabilizing connected to its input.

2. A stand according to claim 1, characterized in that the device for introducing a destabilizing solution into the blood is made in the form of a syringe. Sources of information taken into account in the examination 1. Chaudler A.V. Blood coagulation in the in vitro system, 1958, s, 11 O- 11 4.