SU880425A1 - Composition for stimulation of osteogenesis - Google Patents

Composition for stimulation of osteogenesis Download PDF

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Publication number
SU880425A1
SU880425A1 SU792761914A SU2761914A SU880425A1 SU 880425 A1 SU880425 A1 SU 880425A1 SU 792761914 A SU792761914 A SU 792761914A SU 2761914 A SU2761914 A SU 2761914A SU 880425 A1 SU880425 A1 SU 880425A1
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USSR - Soviet Union
Prior art keywords
composition
crushed
osteogenesis
long tubular
ossification
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Application number
SU792761914A
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Russian (ru)
Inventor
Павел Николаевич Фиалко
Флорид Тимофеевич Темерханов
Давид Яковлевич Бергер
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Кемеровский государственный медицинский институт
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Priority to SU792761914A priority Critical patent/SU880425A1/en
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Publication of SU880425A1 publication Critical patent/SU880425A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

(54) СОСТАВ ДЛЯ СТИМУЛЯЦИИ ОСТЕОГЕНЕЗА(54) COMPOSITION FOR STEAMULATION OF OSTEOGENESIS

Изобретение относитс  к медицине а именно челюстно-лицевой хирургии. Известен состав дл  стимул ции остеогеноза, содержащий измельченные длинные трубчатые кости П. Недостатком состава  вл етс  его сыпучесть, крупные костные частицы состава, что не позвол ет тесно уложить друг к другу микротрансплантаты . В случае заполнени  костной полости сложной формы не достигаетс  плотного прилегани  микротрансплан- татов к ее стенкам,а следовательно, недостаточно полное заполнение костной полости. При непереносимости больным антибиотиков введение послед них в измельченный трансплантат противопоказано , что отрицательно сказы ваетс  на течении послеоперационного периода. Целью изобретени   вл етс  предупреждение рецидивов и сокращение сроков реабилитации. Эта цель достигаетс  тем, что сое; тав дл  стимул ции остеогеноза,- со- держащий измельченные длинные трубчатые кости, дополнительно содержит измельченные  дра окостенени  из тел позвонков, метилурацил и глицерин при следующем соотношении компонентов , вес.ч: Измельченные длинные трубчатые кости 2,0-2,3 Измельченные  дра окостенени  из тел позвонков2,0-2,2 Метилурацил1,0-1,5 Глицерин2,0-2,5 Дп  приготовлени  состава используют костную ткань человека в возрасте от 20 до 37 недель консервированную в 0,5%-ном растворе формалина по общеприн той методике. Метилураци  и глицерин стерилизуют методом автоклавировани . Непосредственно перёд операцией или за сутки до нее длинные трубчатые кости плода челоBACKGROUND OF THE INVENTION The invention relates to medicine, namely, maxillofacial surgery. A known composition for the stimulation of osteogenosis, containing crushed long tubular bones P. The disadvantage of the composition is its flowability, large bone particles of the composition, which does not allow the microtransplants to fit closely together. In the case of filling the bone cavity of a complex shape, the micrografts do not fit snugly against its walls, and, consequently, the bone cavity is not completely filled. When patients with antibiotics are intolerant, the introduction of the latter into the crushed graft is contraindicated, which adversely affects the course of the postoperative period. The aim of the invention is to prevent recurrence and shorten the rehabilitation period. This goal is achieved by the fact that soy; To stimulate osteogenesis, containing crushed long tubular bones, it additionally contains crushed ossification cores from vertebral bodies, methyluracil and glycerin in the following ratio of components, parts by weight: Chopped long tubular bones 2.0-2.3 Chopped ossification core from the vertebral bodies 2.0-2.2 Methyluracil1.0-1.5 Glycerol 2.0-2.5 Dp preparation of the composition using human bone tissue aged 20 to 37 weeks preserved in 0.5% formalin solution according to the standard method. Methyluration and glycerin are sterilized by autoclaving. Directly before the operation or the day before it, the long tubular bones of the fetus

Claims (1)

Формула изобретения 1 Состав для стимуляции остеогенеза, содержащий измельченные длинные трубчатые кости, отличающийся тем, что, с целью предупрежденияThe claims 1 Composition for stimulating osteogenesis, containing crushed long tubular bones, characterized in that, in order to prevent 30 рецидивов и сокращения сроков реабилитации, он дополнительно содержит измельченные ядра окостенения из тел позвонков, метилурацил и глицерин при следующем соотношении компонентов,30 relapses and shortening the rehabilitation period, it additionally contains crushed ossification nuclei from the vertebral bodies, methyluracil and glycerin in the following ratio of components, 35 35 вес.ч: weight.h: Измельченные длинные Shredded long трубчатые кости tubular bones 2,0-2,3 2.0-2.3 Измельченные ядра Crushed kernels окостенения из тел body ossification 40 40 позвонков vertebrae 2,0-2,2 2.0-2.2 Метилурацил Methyluracil 1,0-1,5 1.0-1.5 Глицерин Glycerol 2,0-2,5 2.0-2.5
SU792761914A 1979-03-26 1979-03-26 Composition for stimulation of osteogenesis SU880425A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU792761914A SU880425A1 (en) 1979-03-26 1979-03-26 Composition for stimulation of osteogenesis

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Application Number Priority Date Filing Date Title
SU792761914A SU880425A1 (en) 1979-03-26 1979-03-26 Composition for stimulation of osteogenesis

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SU880425A1 true SU880425A1 (en) 1981-11-15

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073373A (en) * 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5284655A (en) * 1989-09-21 1994-02-08 Osteotech, Inc. Swollen demineralized bone particles, flowable osteogenic composition containing same and use of the composition in the repair of osseous defects
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073373A (en) * 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5284655A (en) * 1989-09-21 1994-02-08 Osteotech, Inc. Swollen demineralized bone particles, flowable osteogenic composition containing same and use of the composition in the repair of osseous defects
US5484601A (en) * 1989-09-21 1996-01-16 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US9999520B2 (en) 2000-07-19 2018-06-19 Warsaw Orthopedic, Inc. Osteoimplant and method of making same

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