SU813844A1 - Composition for low-temperature preservtion of leukocytes - Google Patents

Composition for low-temperature preservtion of leukocytes Download PDF

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Publication number
SU813844A1
SU813844A1 SU792792541A SU2792541A SU813844A1 SU 813844 A1 SU813844 A1 SU 813844A1 SU 792792541 A SU792792541 A SU 792792541A SU 2792541 A SU2792541 A SU 2792541A SU 813844 A1 SU813844 A1 SU 813844A1
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SU
USSR - Soviet Union
Prior art keywords
leukocytes
composition
low
temperature
preservtion
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Application number
SU792792541A
Other languages
Russian (ru)
Inventor
И.И. Георгадзе
Л.Х. Каличава
И.К. Махатадзе
Н.Ш. Чигогидзе
Original Assignee
Тбилисский Научно-Исследовательский Институт Вакцин И Сывороток
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Application filed by Тбилисский Научно-Исследовательский Институт Вакцин И Сывороток filed Critical Тбилисский Научно-Исследовательский Институт Вакцин И Сывороток
Priority to SU792792541A priority Critical patent/SU813844A1/en
Application granted granted Critical
Publication of SU813844A1 publication Critical patent/SU813844A1/en

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Description

ход жизнеспособных лейкоцнтов (95%) и сохран ет их снособность к биосинтезу интерферона в титрах, соответствзющих производственным стандартам.the course of viable leukocytes (95%) and retains their ability to interferon biosynthesis in titers that meet production standards.

Физико-химические свойства и биологическа  активность интерферона из лейкоцитов , подвергавшихс  длительному (1 год) низкотемпературному замораживанию посредством предложенного состава, не отличались от свойств интерферона, синтезированного свежими лейкоцитами.The physicochemical properties and biological activity of interferon from leukocytes subjected to prolonged (1 year) low-temperature freezing by means of the proposed composition did not differ from the properties of interferon synthesized with fresh leukocytes.

Предложенный состав найдет широкое практическое применение.The proposed composition will find wide practical application.

Дл  промышленного получени  человеческого лейкоцитарного интерферона требуетс  свежа  донорска  кровь (не позднее 24-36 ч после вз ти ), что создает значительные трудности дл  его непрерывного производства, особенно в период вспышек эпидемии гриппа и ОРЗ. Предложенный состав , сохран   на длительный срок жизнеспособность лейкоцитов - продуцентов интерферона , позволит обеспечить фонд сырь  дл  непрерывного производства человеческого лейкоцитарного интерферона.For commercial production of human leukocyte interferon, fresh donor blood is required (no later than 24-36 hours after withdrawal), which creates significant difficulties for its continuous production, especially during outbreaks of the epidemic of influenza and ARD. The proposed composition, preserving the long-term viability of leukocytes - interferon producers, will provide a fund of raw materials for the continuous production of human leukocyte interferon.

Описанный состав может быть использован в системе здравоохранени  как в вирусологической , так и гематологической практике. Возможно применение лейкоцитов , подвергнутых длительному замораживанию при помош,и предложенного состава, после их размораживани  дл  гемотрансфузии .The composition described may be used in the health care system in both virological and hematological practice. It is possible to use leukocytes subjected to prolonged freezing with the aid of the proposed composition, and the proposed composition, after thawing them for blood transfusion.

Claims (1)

1. Низкотемпературное консервирование тканей. Н. С. Пушкарь - Криобиологи  и криомедицина, 1977, № 3, с. 3-8.1. Low-temperature preservation of tissues. N.S. Pushkar - Cryobiologists and Cryomedicine, 1977, No. 3, p. 3-8.
SU792792541A 1979-07-06 1979-07-06 Composition for low-temperature preservtion of leukocytes SU813844A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU792792541A SU813844A1 (en) 1979-07-06 1979-07-06 Composition for low-temperature preservtion of leukocytes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU792792541A SU813844A1 (en) 1979-07-06 1979-07-06 Composition for low-temperature preservtion of leukocytes

Publications (1)

Publication Number Publication Date
SU813844A1 true SU813844A1 (en) 1982-01-30

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SU792792541A SU813844A1 (en) 1979-07-06 1979-07-06 Composition for low-temperature preservtion of leukocytes

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SU (1) SU813844A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2169904B (en) * 1984-12-30 1989-06-07 Hayashibara Biochem Lab Process for producing human-specific gamma-interferon and method for assaying the gamma-interferon productivity of blood.
US20100255524A1 (en) * 2007-05-31 2010-10-07 Qiagen Gmbh Method for stabilising a biological sample
RU2464991C1 (en) * 2011-07-15 2012-10-27 Учреждение Российской академии наук Институт физиологии Коми научного центра Уральского отделения РАН Frost protection solution for nuclear blood cell freezing

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2169904B (en) * 1984-12-30 1989-06-07 Hayashibara Biochem Lab Process for producing human-specific gamma-interferon and method for assaying the gamma-interferon productivity of blood.
US20100255524A1 (en) * 2007-05-31 2010-10-07 Qiagen Gmbh Method for stabilising a biological sample
US8372637B2 (en) * 2007-05-31 2013-02-12 Qiagen, Gmbh Method for stabilising a biological sample
RU2464991C1 (en) * 2011-07-15 2012-10-27 Учреждение Российской академии наук Институт физиологии Коми научного центра Уральского отделения РАН Frost protection solution for nuclear blood cell freezing

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