SU790620A1 - 2,4'-dichloro-5-aminobenzophenone as starting product for synthesis of drugs with antihelminthic action - Google Patents

2,4'-dichloro-5-aminobenzophenone as starting product for synthesis of drugs with antihelminthic action Download PDF

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Publication number
SU790620A1
SU790620A1 SU792796600A SU2796600A SU790620A1 SU 790620 A1 SU790620 A1 SU 790620A1 SU 792796600 A SU792796600 A SU 792796600A SU 2796600 A SU2796600 A SU 2796600A SU 790620 A1 SU790620 A1 SU 790620A1
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USSR - Soviet Union
Prior art keywords
dichloro
aminobenzophenone
synthesis
drugs
antihelminthic
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SU792796600A
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Russian (ru)
Inventor
Ф.С. Михайлицин
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Ордена Трудового Красного Знамени Институт Медицинскойпаразитологии И Торпической Медицины Им.E.И.Марциновского
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Priority to SU792796600A priority Critical patent/SU790620A1/en
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Description

нием смеси 21,15 г 2-хлор-5-нитробензойной кислоты и 25 мл хлористого тионила в течение 2 ч прибавл ют 75 мл сухого хлорбензола и 17,0 г хлористого алюмини  и выдерживают смесь при50-бО С 2,5 ч, охлаждают и выливсцот в 100 мл воды и отгон ют с вод ным паром.Выделившийс  твердый продукт отфильтровывают и промывают водой. Получают светло-желтые кристаллы с т.пл. 94-95° С (из спирте.75 ml of dry chlorobenzene and 17.0 g of aluminum chloride are added over 2 h by adding a mixture of 21.15 g of 2-chloro-5-nitrobenzoic acid and 25 ml of thionyl chloride and the mixture is kept at a temperature of 2.5 hours, cooled and poured into 100 ml of water and distilled off with steam. The separated solid product is filtered and washed with water. Light yellow crystals are obtained with mp. 94-95 ° C (from alcohol.

Б Получение 2 ,4-дихлор-5-аминобензофенона .B Preparation of 2, 4-dichloro-5-aminobenzophenone.

К раствору 22,5 г 2,4 -дихлор-5гнитробензофенона в 175 мл этанола постепенно прибавл ют раствор 75,0 двухлористого олова в 75 мл концентри рованной сол ной кислоты и выдерживают реакционную массу при перемешивании и кипении 2 ч, после чего выливают на 1 л воды и при охлаждении добавл йт до щелрчной реакции водный раствор аммиака . Выпавший осадок отфильтровывают , сушат и сухое вещество кип т т в 300 мл метанола. Отфильтровывают нерастворимые неорганические примеси метанольный раствор упаривают до объема примерно 30-50 мл и охлаждают выкристаллизовываетс  2,4-дихлор- . -5-аминобензофенон в виде светложелтых кристаллов с т.пл. 94-95 С. Выход 41,5%.To a solution of 22.5 g of 2,4-dichloro-5-nitrobenzophenone in 175 ml of ethanol, a solution of 75.0 tin dichloride in 75 ml of concentrated hydrochloric acid is gradually added and the reaction mixture is kept under stirring and boiling for 2 hours, then poured onto 1 l of water and while cooling add to the alkaline reaction an aqueous solution of ammonia. The precipitate formed is filtered off, dried and the solid is boiled in 300 ml of methanol. The insoluble inorganic impurities are filtered off and the methanol solution is evaporated to a volume of about 30-50 ml and the 2,4-dichloro is crystallized. -5-aminobenzophenone in the form of light yellow crystals with so pl. 94-95 C. Yield 41.5%.

йлчислено, % се 26,6; N 5,3.number,% ce 26.6; N 5.3.

0,3 .0.3.

Найдено, %: Cg 26,5, N 5,4.Found: Cg 26.5, N 5.4.

Таким образом, использование 2,4 -дихлор-5 аминобензофенона в качестве исходного продукта дл  синтеза лекарственных препаратов дает возможность получить новый антигельминтик (г-937), имеющий более высокий терапевтический индекс и меньшую токсичность по сравнению с известным фасциалацидным препаратом Клиоксанид (2-ацетокси-4-хлор-3,5-дийодбенз анилидом ).Thus, the use of 2,4-dichloro-5 aminobenzophenone as a starting material for the synthesis of drugs makes it possible to obtain a new anthelmintic (g-937), which has a higher therapeutic index and lower toxicity compared with the known fascial acid preparation Clioxanide (2-acetoxy -4-chloro-3,5-diiodobenz anilide).

Claims (1)

1. За вка ФРГ № 2311229, кл. 120 16, опублик, 1976.1. For the application of the Federal Republic of Germany No. 2311229, cl. 120 16, published in 1976.
SU792796600A 1979-06-01 1979-06-01 2,4'-dichloro-5-aminobenzophenone as starting product for synthesis of drugs with antihelminthic action SU790620A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU792796600A SU790620A1 (en) 1979-06-01 1979-06-01 2,4'-dichloro-5-aminobenzophenone as starting product for synthesis of drugs with antihelminthic action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU792796600A SU790620A1 (en) 1979-06-01 1979-06-01 2,4'-dichloro-5-aminobenzophenone as starting product for synthesis of drugs with antihelminthic action

Publications (1)

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SU790620A1 true SU790620A1 (en) 1981-07-30

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