SU750983A1 - N-[4-(3,3-dimethyltriazeno)phenylsulfonyl] lauroylamide displaying anti-inflammatory activity - Google Patents

N-[4-(3,3-dimethyltriazeno)phenylsulfonyl] lauroylamide displaying anti-inflammatory activity Download PDF

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Publication number
SU750983A1
SU750983A1 SU792722299A SU2722299A SU750983A1 SU 750983 A1 SU750983 A1 SU 750983A1 SU 792722299 A SU792722299 A SU 792722299A SU 2722299 A SU2722299 A SU 2722299A SU 750983 A1 SU750983 A1 SU 750983A1
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SU
USSR - Soviet Union
Prior art keywords
dimethyltriazeno
phenylsulfonyl
lauroylamide
inflammatory activity
displaying anti
Prior art date
Application number
SU792722299A
Other languages
Russian (ru)
Inventor
Д.А. Казлаускас
М.А. Кажемекайте
В.И. Астраускас
З.-В.Н. Срюбайте
Original Assignee
Институт биохимии АН ЛитССР
Научно-Исследовательский Институт Экспериментальной И Клинической Медицины Министерства Здравоохранения Литсср
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Application filed by Институт биохимии АН ЛитССР, Научно-Исследовательский Институт Экспериментальной И Клинической Медицины Министерства Здравоохранения Литсср filed Critical Институт биохимии АН ЛитССР
Priority to SU792722299A priority Critical patent/SU750983A1/en
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Publication of SU750983A1 publication Critical patent/SU750983A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Description

Изобретение относитс  к области синтеза биологически активных химических соединений, конкретно, к синтезу Ы Г4-(3,3-диметилтриазено)фенилсульфонил лауроиламида , про вл ющего противовоспалительное действие.The invention relates to the field of synthesis of biologically active chemical compounds, specifically, to the synthesis of LH4- (3,3-dimethyltriazeno) phenylsulfonyl lauroyl amide, which has an anti-inflammatory effect.

Указанные свойства позвол ют предполагать возможность применени  его в медицине.These properties suggest the possibility of its use in medicine.

Известен 4-(3,3-диметилтриазено)N-ацетилбензолсульфамид формулы ( CH3) -( SOgNHCOCHs 4- (3,3-dimethyltriazeno) N-acetylbenzenesulfamide of formula (CH3) - (SOgNHCOCHs is known

 вл ющийс  наиболее близким аналогом по структуре к предложенным соединени м , который также про вл ет противовоспалительное действие, однако его токсичность несколько выше токсичности фенилбутазона - широко примен емого противо1юспалительного препарата .which is the closest analogue in structure to the proposed compounds, which also exhibits an anti-inflammatory effect, but its toxicity is somewhat higher than that of phenylbutazone, a widely used anti-inflammatory drug.

Целью изобретени   вл етс  сниже ние токсичности, а также расширение The aim of the invention is to reduce toxicity, as well as the expansion

СЛ арсенала средств воздействи  на жио вой организм.SL arsenal of means of affecting the body.

Это достигаетс  новой химической This is achieved by a new chemical

00 структурой N-(4-(3,3-диметилтриазеоо но) фенилсульфоншЛт.ауро ил амида, котора  выражаетс  формулой I:00 by the structure of N- (4- (3,3-dimethyltriazaeono)) phenylsulfonic Lt. auro yl amide, which is expressed by the formula I:

Предложенное соединение получают взаимодействием 4-(3,3-диметилтриазено )-бензолсульфамида с хлорангидридом лауроиловой кислоты в раство«:н ,ьн-ы- -О- ° ° The proposed compound is obtained by the interaction of 4- (3,3-dimethyltriazeno) -benzenesulfamide with lauroic acid chloride in solution ": n, ln-s- -O- °

Claims (1)

¢54) N- [4-(3,3-ДИМЕТИЛТРИАЗЕНО) ФЕНИЛСУЛЬФОНИлЗлАУРОИЛАМИД формулы Т.;¢ 54) N- [4- (3,3-DIMETHYLTRIAZENO) Phenylsulfonylzlauroylamide of the formula T .; (CHjhN~N=N-^^-SOiNHC0(CH?)io CHj ί проявляющий противовоспалительное действие.(CHjhN ~ N = N - ^^ - SOiNHC0 (CH?) Io CHj ί exhibiting anti-inflammatory effect.
SU792722299A 1979-02-05 1979-02-05 N-[4-(3,3-dimethyltriazeno)phenylsulfonyl] lauroylamide displaying anti-inflammatory activity SU750983A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU792722299A SU750983A1 (en) 1979-02-05 1979-02-05 N-[4-(3,3-dimethyltriazeno)phenylsulfonyl] lauroylamide displaying anti-inflammatory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU792722299A SU750983A1 (en) 1979-02-05 1979-02-05 N-[4-(3,3-dimethyltriazeno)phenylsulfonyl] lauroylamide displaying anti-inflammatory activity

Publications (1)

Publication Number Publication Date
SU750983A1 true SU750983A1 (en) 1990-11-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU792722299A SU750983A1 (en) 1979-02-05 1979-02-05 N-[4-(3,3-dimethyltriazeno)phenylsulfonyl] lauroylamide displaying anti-inflammatory activity

Country Status (1)

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SU (1) SU750983A1 (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Авторское свидетельство СССР по за вке № 2625157/23-04, кл. С 07 С 143/82, А 61 К 31/18 ,1978 (не публикуемое). *

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