SU738585A1 - D3-vitamin adjuvant for feed, method and apparatus for preparing - Google Patents

Description

The invention relates to the production of vitamins for animals, in particular to the preparation of a J-vitamin preparation. Currently, for the prevention and treatment of rickets in farm animals, the well-known D-vitamin feed supplements containing vitamin-oil oil and Videin-D are used, which are obtained from photo-resin, which is a complex mixture of substances formed by irradiating with Y-light provitamin 1. The closest to the claimed vitamin feed supplement is the known D-vitamin feed supplement based on photopure, containing, wt.%: vitamin D-25-28, pre-vitamin D-8-10, unturned starting 7-dehydrocholes terine 10-15, by-products of photo-oxidation - the rest is up to 100 2. The deficiencies of this vitamin preparation lies in its low activity and instability: after 6 months of storage it loses its antirachitic activity and is unsuitable As D, is a vitamin supplement to animal feed. Methods for preparing D-vitamin preparations are based on UV irradiation of alcohol solutions of 7-dehydrocholeterol with erythemal and bactericidal lamps or its esters at a wavelength of 302-305 mm, followed by isomerization and concentration of the target product 2. The disadvantages of these methods are that significant amounts are formed toxic photoproducts, which leads to the transformation of the feedstock only 40-45%. In addition, irregularity of irradiation of the whole mass of the provitamin alcohol solution is noted, which leads to a local one: overexposure and a decrease in the amount of vitamin TIj, its localized activity and stability. For the implementation of the method and the production of vitamin preparations or feed additives, devices are used that contain a housing with sources of ultraviolet radiation placed in it and equipped with branch pipes.

o) N31:; 1h. f; , -,. Mr. (n :: h p production. -3.

. idiacs r :: -.:; .. -uy.-: PogpgyiEe 3 ;;;: c v: -u, -i ;;: i Ladiuptey spontaneity of 5) ;; - -

L

Bi P

With fShl-I

iOS - llf-s t

on cholestert

Such D:,; - vitag, w Eu :: .-: - o; -::; and receive with the help of a sucker with which: ;; aK i: Li- Hi :::: that during the irradiation process dd: -; : yy.ssts. ;; alcohol solution / dehydro; o1: /; ts, .g: b: 1 (its effusion is 2vi-c -; - iv3 directly; sleep-gtu s :: about the nature of the total radiation: - hr: -lzi: -: - ;: x and concentrOeZnIe. just / thp pp - hum;:; d t at the same time with the work of the mixture at TfiivinepaTyps; С ii.r- Tf-ir, -; /; 2-2.5 h,

Sposoo Osuishstnl., About y--: - we will hear building 5 3 KOTOuCji ispch: id :: h W.: m; lot irradiation with kpzhchenz in G7S-; PN: housings, with clearances: E: D-3 mb: dch-; p; ::; :::; irradiated rasstorp -; pag; - r;;: g - -,. / zigzagoobrazno, in conjunction with - The connection of the branch pipe. Fig. 1 nzbrozhk about &mc; to jln :. with: 1-Wow device E and-; ; Oscho1, lstpk-tggg go:;: p in FIG. 2 - radiation irradiation (.lsv, -lom section.

The device has herme / - .; . g o:

KORSCHS 1 with viCDCpK-c ero po ero ero ш ш w inside zigziao-OGJ: y; -h;:; elements 2, icoTopbiC BbirfojiFSHv- i;) .; fluorescent lamps 3, caprille p -f ::,) enclosed in metal; n; uimg /.::-- e ha 4 with an annular gap MCEOiy vi:; -; ;: passing from the center of the river to the village

figure X elements 2 soap

 -

Fuels and lubricants j. J. and krainv

The facilities have nozzles b and / for introducing and withdrawing the solution, provided for by the membods house of the third element, through cooling water.

UV irradiation of raw materials asp gfovityoshov D from it devices are not interrupted by slashuedimy opra th yBe7K "Riie f: due to nioi s, i th takpch actirahihigskscch t - t g and s :::; ai .- /:: Ha D ,, and it says with - A, .Ji :: Oi .; C, de7; er 1 ke11 (hb.al1e zia - ;;, rojihiic is simplified by the technologist :: -; stdk glderrata.. I p v3 Tl er 2. Dl;; -innsl feed additive ye, / - DGH prepare 0 , 05--0.2% cir.., - ry. 0.1% solution of 20 g aiehat ;:; - 1 GC (in 100% technical specification: .- n% containing 90-95% base: 3) are dissolved by 3 10 l of this septum (ilt ::;: YuproikpOe) sekrta pka kagreeakki to. After the solution is dissolved, 1 ::::: u- nyh ::::: the jar is cooled to 18-20 to produce in tsg n: - e 3 with an inert gas for air kslorots.Sbl gaezsh ssh-rtrozogs solution of acetate - 7-DGH GFOYEDYAG in: ggapater not rerenoge action; of the rest of the lz 20 erkteysh.kh laglp with lumz-gchoforgkk, with aksi1 / 1 scrap: b5spusk11 in 1111 29le-312 K11L. l / hr, providing 90–95% conversion.The solution obtained after regional treatment is 50 times, i.e. up to 40 ml in a vacuum apparatus, at a temperature of 90 ° C for 2; 5 hours for thermal isolation Superior Echo Dy to Simultaneously Learning Concentration Tracts-south solution. Quantifying oskovnyh components obtained in this way with: :: i :,:.: - pt; Ttr: 1 ptyyu g hromatosprofouogletrmeskmm method iiyTeivS separation:,;: ps ;: E top layer in the system :: ol p-trolley: 1Y zflr (60:40), eluatshi -. ::: si:; estiz ZTILSVIEYA with alcohol followed by g: r; krgofotoiEetr; Soder ::: which are the components in the resulting: -Co: 1 centrate is% acetate - vktami D --- 55-63, ripesmanita D - 12-15, 7-DGH - 5-10, lumstersch1a - 15-20, yield: Vri, eT3Ta BHTaMiSia D for 7-DGH converted acetate is 70-75%. Тгк as zlodchts.p551 in the composition of the concentrate. :: igta: dp :: ai :: sh-; and D is more stable than .number 3HTa :::: tii D -: then it gets polyglugo yciofmreocTb to oxidation and - gu e-: a :: T: vp, x: iiTH4ecKyiO activity dsggel: ce Brem. Example 3. On, 1-1 more optamnoe about the content of the exempt comsite 15, there is a D 5-person-to-person supplement of the following composition: Vttamsh D, .60% Prev: tiOP-: D14 Lyulisterkn16% In the process of storage, it was discovered that during the e - fc kt: Yvnostg. in addition to the “IeLiua i TenbHc in comparison with the supplement, semi-: enkoy in a variety of ways. In the table of Argzvods, the specific outcomes are: analysis of the analyzes of Mr. G. Bitamteyi feed additives, according to: grilled redlogs. In a known manner. About the contents of the original bins. During storage.

Non-reproducible: 7th DGH and oxidized products

Studies have shown that Vitamin D drug preparations, such as Gluchilum-JhiM, are distinguished by a high content of anti-cracking agents of Vitamin D, previa D and lug-tisterine.

68

17

50

) .Product1: s photoclashes that contribute to the dilution of BHiasfHifa D during storage, are not present in a small amount, which means that the drug has a shelf life of up to one year, whereas for preparations obtained by a known method, the shelf life is not more than 6 months.

Thus, the proposed preposition allows a stable D-vitamin supplement for animals to be obtained in a high yield of 55 - .70 with respect to expensive treatment. Production tests of the claimed method and device for its implementation have confirmed the effectiveness of the technology, reliability and ease of operation of the device of the irradiation apparatus.

Claims (3)

1. D, -Vitamin feed supplement containing vitamin D., lumisterol, previtamin D and unconverted 7-dehydrocholesterol, which is due to the fact that, in order to increase its antirachitic activity and stability, the additive contains these ingredients in the following ratio, weight.%: 55-60 Vitamin D, 12-15 Previtamin D Lumsters 15-20 Unturned 7-dehydrocholesterol 5-10 2. A method for producing a D, -Vitamin feed additive according to claim 1, comprising continuous ultraviolet irradiation of a moving stream of a solution of 7-dehydrocholesterol or its esters in an organic solvent, followed by thermal isomerution 385858 and concentrating the target product, characterized in that, during the irradiation process, the moving feed stream is directly contacted with the surface of the irradiation source, and the process is carried out up to 90-95% of provitamin conversion using UV sources with a wavelength of 290-312 nm , and thermal isomerization and concentration are carried out simultaneously when treating the irradiated mixture at a temperature of 70-80 ° C for 2-2.5 hours. 3. An apparatus for carrying out the method of claim 1 of claim 2, comprising a housing with sources of ultraviolet irradiation placed in it, equipped with nozzles for entering the raw material and outputting the target product, characterized in that the irradiation sources are additionally encased in a casing with a gap for the flow of the irradiated solution and placed in the zigzag case, communicating with each other by means of connector nipples. Sources of information taken into account in the examination 1. Berezovsky V. M. Chemistry of vitamins. M., 1973. 2. Chemistry, biochemistry and technology of production of vitamin D, its use in medicine and animal husbandry. Kiev, Naukova Dumka, 1972, p. 80-81. 3. USSR author's certificate number 79274, cl. B 01 J 1/10, 1950.