SU709090A1 - Method of preparing apomorphine solution - Google Patents
Method of preparing apomorphine solution Download PDFInfo
- Publication number
- SU709090A1 SU709090A1 SU772519991A SU2519991A SU709090A1 SU 709090 A1 SU709090 A1 SU 709090A1 SU 772519991 A SU772519991 A SU 772519991A SU 2519991 A SU2519991 A SU 2519991A SU 709090 A1 SU709090 A1 SU 709090A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- solution
- apomorphine
- analgin
- preparing
- water
- Prior art date
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
1one
Изобретение относитс к химикофармацевтической промышленности, а именно к способу получени стабильного инъекционного раствора апоморфина .The invention relates to the chemical and pharmaceutical industry, in particular to a method for producing a stable injection solution of apomorphine.
Известен способ получени раствора апоморфина путем растворени препарата в водном кислом растворе, добавлени стабилизатора и стерилизации 1 ,A known method of obtaining a solution of apomorphine by dissolving the drug in an aqueous acidic solution, adding a stabilizer and sterilizing 1,
Недостатком известного способа вл етс окрашивание раствора в процессе стерилизации, что свидетельствует о разложении стабилизатора или лекарственного препарата.The disadvantage of this method is the staining of the solution during sterilization, which indicates the decomposition of the stabilizer or drug.
Целью изобретени вл етс увеличение сроков хранени .The aim of the invention is to increase shelf life.
Цель достигаетс тем, что препарат раствор ют в водном кислом растворе , добавл ют в качестве стабилизатора анальгин в количестве 0,50 ,05 г: на 1 л раствора и стерилизуют известным способом.The goal is achieved in that the preparation is dissolved in an aqueous acidic solution, analgin in the amount of 0.50.05 g is added as a stabilizer: per 1 liter of the solution and sterilized in a known manner.
Пример 1. Берут 10,0 г апоморфина хлоргидрата, добавл ют 0,1 г анальгина и раствор ют в 500 мл воды дл инъекции, содержащей 40 мл 0,1 N ней-. После растворени компонентов раствор довод т до 1,0 водой дл инъекции, затем разливают вExample 1. 10.0 g of apomorphine hydrochloride is taken, 0.1 g of dipyrone is added and dissolved in 500 ml of water for injection containing 40 ml of 0.1 N neu. After dissolving the components, the solution is adjusted to 1.0 with water for injection, then poured into
ампулы или флаконы и стерилизуют в паровом стерилизаторе ТК-100 в течение 8-10 мин при температуре 121°С и давлении 1 кгс/см .ampoules or vials and sterilized in a steam sterilizer TK-100 for 8-10 minutes at a temperature of 121 ° C and a pressure of 1 kgf / cm.
Концентраци анальгина составл ет 0,01% апоморфина - 1%, рН раствора 2 .Analgin concentration is 0.01% apomorphine - 1%, pH 2.
П р и м.е р 2. Берут 10,0 г апоморфина хлоргидрата, добавл ют Example 2: Take 10.0 g of apomorphine hydrochloride, add
C 0,5 г анальгина и раствор ют в 500,0 мл воды дл инъекции, содержащей 40 мл 0,1 N HCI. После растворени -компонентов раствор довод т до 1,0 л водой дл инъекций, затем C 0.5 g analgin and dissolved in 500.0 ml water for injection containing 40 ml 0.1 N HCl. After the components are dissolved, the solution is adjusted to 1.0 L with water for injection, then
5 разливают в ампулы или флаконы и стерилизуют в паровом стерилизаторе ТК-100 в течение 8-10 мин при 12lc и давлении 1 кгс/см5 poured into ampoules or vials and sterilized in a steam sterilizer TK-100 for 8-10 minutes at 12lc and a pressure of 1 kgf / cm
Концентраци анальгину состав0 л ет 0,05%, апоморфина 1%, рН раств ора 2 .Analgin concentration is 0.05%, apomorphine 1%, pH of solution 2.
Пример 3. Берут 10,0 г апоморфинахлоргидрата, добавл ют 0,05 г анальгина и раствор ют в Example 3. 10.0 g of apomorphine hydrochloride is taken, 0.05 g of dipyrone is added and dissolved in
5 500 мл воды дл инъекции, содержащей 40 мл 0,1 N НС1. После растворени компонентов раствор довод т до 1,0 л водой дл инъекций, затем разливают в ампулы или флаконы и 5 500 ml of water for injection containing 40 ml of 0.1 N HCl. After the components are dissolved, the solution is brought to 1.0 l with water for injection, then poured into ampoules or vials and
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU772519991A SU709090A1 (en) | 1977-08-18 | 1977-08-18 | Method of preparing apomorphine solution |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU772519991A SU709090A1 (en) | 1977-08-18 | 1977-08-18 | Method of preparing apomorphine solution |
Publications (1)
Publication Number | Publication Date |
---|---|
SU709090A1 true SU709090A1 (en) | 1980-01-15 |
Family
ID=20723148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU772519991A SU709090A1 (en) | 1977-08-18 | 1977-08-18 | Method of preparing apomorphine solution |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU709090A1 (en) |
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1977
- 1977-08-18 SU SU772519991A patent/SU709090A1/en active
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