SU667201A1 - Method of allotransplantation of lungs - Google Patents
Method of allotransplantation of lungsInfo
- Publication number
- SU667201A1 SU667201A1 SU762411487A SU2411487A SU667201A1 SU 667201 A1 SU667201 A1 SU 667201A1 SU 762411487 A SU762411487 A SU 762411487A SU 2411487 A SU2411487 A SU 2411487A SU 667201 A1 SU667201 A1 SU 667201A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- allotransplantation
- immunosuppressant
- lung
- recipient
- lungs
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
(54) СПОСОБ АЛЛОТРАНСПЛАНТАЦИИ ЛЕГКИХ(54) METHOD OF LUNG ALL-TRANSPLANTATION
II
Изобретение относитс к области медицины , в частности к трансплантации органов и тканей.This invention relates to the field of medicine, in particular to the transplantation of organs and tissues.
. Известен способ аллотрансплантации легких с применением иммуносупрессора 1.. The known method of allotransplantation of the lungs using immunosuppressant 1.
Однако при известном способе аллотрансплантации легких возможно раннее отторжение трансплантата.However, with a known method of lung allotransplantation, graft rejection is possible early.
Целью изобретени вл етс предупреждение раннего отторжени трансплантата.The aim of the invention is to prevent early graft rejection.
Эта цель достигаетс тем, что по предлагаемому способу в качестве иммуносупрессора примен ют М-фенилакрилиден-Ы-бис- (2-хлорэтил)-гидразин (акфезин) и ввод т его в количестве 8-12 мг/кг веса реципиента в регионарные узлы непосредственно во врем операции.This goal is achieved in that according to the proposed method, M-phenyl acrylidene-Y-bis (2-chloroethyl) -hydrazine (acfezin) is used as an immunosuppressant and administered in an amount of 8-12 mg / kg of recipient weight to regional nodes during surgery.
Осуществление предлагаемого способа по сн етс на примере аллотрансплантации легкого в эксперименте на собаках.The implementation of the proposed method is illustrated by the example of lung allotransplantation in an experiment on dogs.
После соответствующей подготовки и обезболивани собаке (донору) производ т торакотомию в п том межреберье с рассечением легочной св зки и элементов корн . Удал ют левое легкое. Сосудистую систему удаленного препарата промывают охлажденным физиологическим раствором (t + 4°C под давлением 40 см вод ного столба).After appropriate preparation and anesthesia, the dog (donor) is subjected to thoracotomy in the fifth intercostal space with dissection of the pulmonary ligament and root elements. The left lung is removed. The vascular system of the removed preparation is washed with cooled saline (t + 4 ° C under a pressure of 40 cm of water column).
Параллельно осуществл ют вторую операцию - имплантацию аллотрансплантата.In parallel, a second operation is performed - allograft implantation.
После соответствующей обработки кожи и обезболивани в п том межреберье у собаки производ т стандартную торакотомию. Пересекают легочные св зки, и элементы корн . Затем легкое реципиента удал ют и на . его место в полость грудной клетки внедр ют заготовленный аллотрансплантат с последующим соединением одноименных элементов корн легкого донора и реципиента. Непосредственно после завершени пересадки легкого у реципиента отпрепарируют лимфоузлы средостени (или лимфатический сосуд ниже подколенной- мки) и медленно ввод т соответствующую дозу иммуносупрессора .After appropriate skin treatment and anesthesia in the fifth intercostal space, a standard thoracotomy is performed in the dog. Cross the pulmonary ligaments, and elements of the root. Then the recipient's lung is removed and on. its place in the cavity of the thorax is inserted into the prepared allograft with the subsequent connection of the same elements of the lung root of the donor and the recipient. Immediately after completion of the lung transplant in the recipient, mediastinal lymph nodes (or lymphatic vessel below the popliteal gland) are prepared and the appropriate dose of immunosuppressant is slowly administered.
В качестве иммуносупрессора примен ют акфезин в виде масл ного раствора, содержащего соответствующую дозу препарата, исход из расчета 8-12,мг/кг веса реципиента . Рану зашивают полностью.Acfezine is used as an immunosuppressant in the form of an oil solution containing the appropriate dose of the preparation, based on the calculation of 8–12 mg / kg of weight of the recipient. The wound is sewn up completely.
Результаты наблюдений показали значительное увеличение выживаемости собакThe results of the observations showed a significant increase in the survival of dogs
(средн вБ1Живаемость 26,6 дней, максимальна 59 дней), практически исключено ранее отторжение трансплантата.(average vB1Flame is 26.6 days, maximum 59 days), graft rejection is practically impossible before.
Введение акфезина значительно снижает общее токсическое воздействие на органйзмы , по сравнению с другими иммуносупрессорами . Терапевтический эффект достигаетс разовым введением акфезина.The introduction of achesin significantly reduces the overall toxic effect on the organisms, compared with other immunosuppressants. The therapeutic effect is achieved by a single administration of Acfezin.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU762411487A SU667201A1 (en) | 1976-10-12 | 1976-10-12 | Method of allotransplantation of lungs |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU762411487A SU667201A1 (en) | 1976-10-12 | 1976-10-12 | Method of allotransplantation of lungs |
Publications (1)
Publication Number | Publication Date |
---|---|
SU667201A1 true SU667201A1 (en) | 1979-06-15 |
Family
ID=20679650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU762411487A SU667201A1 (en) | 1976-10-12 | 1976-10-12 | Method of allotransplantation of lungs |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU667201A1 (en) |
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1976
- 1976-10-12 SU SU762411487A patent/SU667201A1/en active
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