SU666172A1 - Potassium salt of 2-aminomethacrylyl-8-naphthol-6-sulphoacid as monomer for synthesis of sulphocationites-sorbents of biologically active substances - Google Patents

Description

Photoacids are obtained by condensation of H1 with 8-naphgol ° 6-; acidic acids with an excess of megacrylic acid chloride in an alkaline medium.

The condensation reaction should be carried out at temperatures up to + 10 ° C in order to avoid the polymerization of methacrylic acid chloride. In this case, an excess of acid chloride is taken to obtain the desired product with a high yield. the course.

The advantages of using the sodium salt of 2 aminomegacrylyl-8-naphgol-6-: ulcer acids as a monomer is that it enters into a copolymerization reaction with li- and polyvinyl compounds in the presence of radical-type plaques to form a three-dimensional polymer with a yield up to the monomer is more than 90%. The polymer obtained on the basis of this compound is soluble in water, dimethylformamide, aqueous solutions of AC. succinic acid

Example. To a solution of 167.5 g of 2-amino 8 naphthol-6 sulfonic acid in 700 ml 2 n. L / AOH solution cooled to +4 s, 154.9 g of meuacrylic acid acid chloride and 2 n are added over 1 h, jVaOH solution so that the pH of the reaction medium is maintained in the interval 8-10, and the temperature of the medium remains in the limit og -2 to.

The precipitate formed is filtered and dissolved in 500 ml of 2N. L / ID The resulting solution is neutralized with concentrated HCt to pH 8. The precipitate is filtered off, dried and recrystallized from water to obtain 211.6 g (92%) of the sodium salt of 2-aminomethacryl-8-naphthol 6-sulfonic acid, mp, above 30 ° C with decomposition .

Found,%: N3.67; $ 7.90.

Calculated,%: L3,66; S 8.35,

Example 2 Sodium salt of 2 ° -aminomegacryl-8 "afthol-6-sulfonic acid was tested to obtain sulfonic cation B,

By polymerizing it in the presence of the initiator of the radical type of dinigryl azo diiso-butyric acid and long chain crosslinking agents egylmendimegacrylamide, hexamethylenedimethacrylamide in the medium, sulfonic cation exchangers were obtained, the properties of which are shown in Table 1. Ta, blits 1

Thus, the products obtained by polymers are sulfonic cations, KH (the swelling coefficient of which can be varied over a wide range. The resulting sulfocagonites are irregular, brown-colored grains. They do not dissolve in water, weak solutions of acids n alkalis, organic solvents. Example 3. Sulfocationone based on sodium salt 2 aminomethacrylyl 8-nafgol 6 sulfonic acid was used to sorb biologically active substances containing heterodonic For the proposed sulfocation They determine the economic affinity of TI for adenosine, which are compared with those determined for sulfo cationionis produced by industry (Table 2). Table 2 Coefficient of Sulfur cation exchanger relative to adenoэein CHK-35 G (sodium salt of inomethacryl-8 naphthol " 6: ulcerative acid, 35% hexamine gilendimethacrylamide)

Continued table. 2

The selectivity coefficient relative to adenosine CHK-UG150 CHK-25E (crosslinking ethylene dimethacrylamide, 25%) 116 CHK-10E170 Testing the samples obtained regarding the sorption of biologically active substances containing heterocycles (adenosine) shows that the proposed solo cations have a selectivity of 3 4 times higher in comparison with the known kationitimi.

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Claims (1)

Formula invented and Sodium salt 2 amE1Nomv gaerylil 8 "" aftol 6-sulfoxys of formula HE SAME-CfO-C CH. as a monomer for the synthesis of sulfocagionite sorbents of biologically active substances containing heterocycles. Sources of information taken into account in the examination 1. UK Patent 1288281, cl. C 07 C 143/00, 1972, 2, Vasilyev A. A. Synthesis of polymeric insoluble sulfonic acids, Science, 1971, p. 242 .. 3 "In eigand chHi, the methods of acceleration in organic chemistry, M., Ch. 14, 1968, p.