SU657022A1 - Method of obtaining imide of cyclopentane-1,2-dicarboxylic acid - Google Patents

Method of obtaining imide of cyclopentane-1,2-dicarboxylic acid

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Publication number
SU657022A1
SU657022A1 SU772483017A SU2483017A SU657022A1 SU 657022 A1 SU657022 A1 SU 657022A1 SU 772483017 A SU772483017 A SU 772483017A SU 2483017 A SU2483017 A SU 2483017A SU 657022 A1 SU657022 A1 SU 657022A1
Authority
SU
USSR - Soviet Union
Prior art keywords
cyclopentane
dicarboxylic acid
ammonia
ether
temperature
Prior art date
Application number
SU772483017A
Other languages
Russian (ru)
Inventor
Лариса Николаевна Клапонина
Галина Васильевна Торяник
Вера Васильевна Мороз
Original Assignee
Харьковский научно-исследовательский институт эндокринологии и химии гормонов
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Харьковский научно-исследовательский институт эндокринологии и химии гормонов filed Critical Харьковский научно-исследовательский институт эндокринологии и химии гормонов
Priority to SU772483017A priority Critical patent/SU657022A1/en
Application granted granted Critical
Publication of SU657022A1 publication Critical patent/SU657022A1/en

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  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (2)

П р и м е p. 32 г циклопентан-1,2-дикарбоноБой кислоты раствор ют в 9О мл водного раствора амми ака и в течение 1 ч нагревают на масл  ной (или металлической) бане при 9010О С, Повышают температуру банй до 1О5-108 С и отгон ют воду, после чего температуру медленно повьшают до 31О и собирают фракцию с т. кип. 270-300° По охлаждении продукт реакции раствор ют в 6О мл 5%-ного едкого натра, имид экстрагируют эфиром. Эфирные выт жки объедин ют, сушат над сернокислым магнием (натрием), отгон ют растворитель, остаток кристаллизуют из смеси н-гексана с толуолом (1:1). Выход целевого продукта 13,7 г, 67% в расчете на вступившую в реакцию кислоту, т. пл. 85-87 С. Водно-щелочной слой подкисл ют разбавленной (1:1) сол ной кислотой до рН 3 и экстрагируют эфиром. После отгонки эфира, остаток кристаллизуют из воды. Выдел ют Э,2 г не вступившей в реакцию циклопёнтан-1,2-дикар бонсжой кислоты., Строение целевого продукта подтверждают данными элементного анализа и ИК-спектрамй, ; Найдено,%: С 6О, 68; 6О,37; не, 57} 6,74; К1О,21; 9,94; . Вычислено,%: С 60,43; Н 6,47; Н 10,07. Формула изобретени  1. Способ получени  имида циклопентан-1 ,2-.дикарбоновой кислоты из циклопентан-1 ,2-дикарбоновой кислоты и аммиака при повышенной температуре, отличающийс  тем, что, с целью повьпиени  выхода целевого продукта с упрощени  технологии процесса, циклопентан-1,2-дикарбоновую кислоту непосредственно ввод т во взаимодействие с избытком водного раствора аммиака при температуре 90-100 с последующим пиролизом образовавшейс  аммонийной соли при 270-ЗОО°С. PRI m e p. 32 g of cyclopentane-1,2-dicarboxylic acid is dissolved in a 9O ml of an aqueous solution of ammonia and heated for 1 hour in an oil (or metal) bath at 9010 ° C. The temperature of the bath is raised to 1010-108 ° C and water is distilled off, after which the temperature is slowly raised to 31O and the fraction is collected from the so-called bale. 270-300 ° Upon cooling, the reaction product is dissolved in 6O ml of 5% sodium hydroxide, the imide is extracted with ether. The ether extracts are combined, dried over magnesium sulfate (sodium), the solvent is distilled off, the residue is crystallized from a mixture of n-hexane and toluene (1: 1). The yield of the target product is 13.7 g, 67% (based on the reacted acid, t. Pl. 85-87 ° C. The alkaline aqueous layer is acidified with diluted (1: 1) hydrochloric acid to pH 3 and extracted with ether. After distilling off the ether, the residue is crystallized from water. E, 2 g of unreacted cyclopentane-1,2-savone bonshoic acid, is recovered. The structure of the target product is confirmed by elemental analysis data and an IR spectrum,; Found,%: C 6O, 68; 6O, 37; no, 57} 6.74; K1O, 21; 9.94; . Calculated,%: C 60.43; H 6.47; H 10.07. Claim 1. Method for producing imide cyclopentane-1, 2-dicarboxylic acid from cyclopentane-1, 2-dicarboxylic acid and ammonia at elevated temperature, characterized in that, in order to improve the yield of the target product with the simplification of the process technology, cyclopentane-1 , 2-dicarboxylic acid is directly reacted with an excess of an aqueous solution of ammonia at a temperature of 90-100, followed by pyrolysis of the formed ammonium salt at 270 ° -ZOO ° C. 2. Способ получени  имида циклопентан-1 ,2-дикарбоновой кислоты по п. 1, отличающ и.{;й с   тем, что используют трехкратный избыток 25%-«ого водного раствора аммиака. Источники информации, прин тые во внимание при экспертизе i.R.&mot,Heev. СЫгтп. Дс1с., 42,67 fi9S9) „ifbejj einigfe AzabicycEooctane Und defen Tlepivate 2. The method of producing imide cyclopentane-1, 2-dicarboxylic acid according to claim 1, wherein i; {; s so that they use a threefold excess of 25% aqueous ammonia solution. Sources of information taken into account in the examination of i.R. & mot, Heev. Sygtp. Ds1s., 42,67 fi9S9) „ifbejj einigfe AzabicycEooctane Und defen Tlepivate
SU772483017A 1977-05-05 1977-05-05 Method of obtaining imide of cyclopentane-1,2-dicarboxylic acid SU657022A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU772483017A SU657022A1 (en) 1977-05-05 1977-05-05 Method of obtaining imide of cyclopentane-1,2-dicarboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU772483017A SU657022A1 (en) 1977-05-05 1977-05-05 Method of obtaining imide of cyclopentane-1,2-dicarboxylic acid

Publications (1)

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SU657022A1 true SU657022A1 (en) 1979-04-15

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SU772483017A SU657022A1 (en) 1977-05-05 1977-05-05 Method of obtaining imide of cyclopentane-1,2-dicarboxylic acid

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100424077C (en) * 2005-06-07 2008-10-08 台州市四维化工厂 Cyclopentane1,2-diimide preparation method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100424077C (en) * 2005-06-07 2008-10-08 台州市四维化工厂 Cyclopentane1,2-diimide preparation method

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