SU649296A3 - Insecticide-acaricide - Google Patents

Description

one

The ognosigs isobregnation of insect control agents against ticks, namely insecticide-acaricides based on the derivative S-diphenylmethylthiophosphate.

A means is known on the basis of 0, O-diethyl-5-diphenylmethylthiophosphate and the usual additives, which possess pesgicidal activity i. However, its activity is insufficient.

The aim of the invention is to find a new insecticoacaricidal agent with a higher biological activity.

It is proposed to use a 5-diphenylmethylthiophosphate derivative of the general formula and 2 as an insecticoacaricidal agent.

L / Osgn,

F

CD

where R, and) each means a hydrogen atom or |. chlorine,

in the amount of 0.5-99.5 wt.%.

Compounds of general formula T can be prepared by the following known method;

SNH

Ny1

Yes

 + Me hal (iv)

2 (f where f, Rjj and have the specified value:

Nab means a halogen atom; Mb - alkaline meta; u1, in particular, sodium or potassium.

The specimen is carried out at normal pressure, at a temperature of 0-150 ° C, preferably at 20-80 ° C, and in inert solutions with respect to reagents or diluent gels. f.lna of this are suitable, for example, aromatic hydrocarbons, halohydrocarbons, chlorinated alkanes having a carbon atom, a simple ester, ester, kegon, nigril. The form of use of drugs is normal.

Example 1. Getting O-atil- "5 propyl-B-diphenylmethyl ester of dithiophosphoric acid.

to a solution of 18.5 g of bromodiphenylmethyl in 100 ml of absolute acetonitrile, at room temperature, 19 g of 0-ethyl-6 Lropyl dithiophosphoric acid potassium is added in portions. The reaction mixture is then stirred for 12 hours and filtered. After evaporation of the filtrate, the residue is treated with ether, the resulting solution is washed 2 times (1OO ml) with water and the organic phase is dried over sodium sulfate. Crude O-ethyl "5-propyl-3-diphenylmethyl ester of dithiophosphoric acid of the formula

.

C1

//

// H

C1

H I

Cl

$ I About T-OOj-Hj

$ С1зН7 (compound 4), P 1,5991,

Example 2. Insecticidal action on Myeka domestka.

1 ml of an acetone solution containing 5 mg of the test compound is pipetted into a Petri dish. After 1 hour, Yu experienced insects (MusKO domestica) would be in a state of cold numbness and the cup was closed again. Two cups are used per test subject and the evaluation of the effect is made after 0, 5, 1, 2, 4 and 8 hours. As a stadium, a known compound, used as a prototype, is used

(V)

0 F-OC2ir5S-C31I7-W

(compound 1), which is purified by chromatography: on a silica gel column, p 1.5878.

The following compounds are prepared in a similar manner:

/

//

HE

10 P-OSgK5 SC-jH -ff (compound 2), p 1.5930;

Insecticidal effect is evaluated according to the tibal scale:

5 death down 0.5 h; 4 .- 100% - and death after 1 h; 3 100% "for death after 2 hours; 2 95-10O% ““ and death after 8 h; 1 inactive for 8 hours. The results of the experiment are shown in Table. one,

T a b

l and c

Compound Score, score

3

one

Q-P-OC HS

$ CzN7 (compound 3), nl 1.5974;

PRI me R. 3. Insecticidal effect on Aedes.

Using insects of the species AedeS aégypti instead of Musca domesticQ and i ml of an acetone solution containing 1 mg of the test compound, the procedure described in example 2 is repeated. The results are shown in Table. 2