SU648101A3 - Method of obtaining stable polymorphic form of 1-oxy-3-(1'1'-dimethylheptyl)-6,6-dimeth]-6,6a,8,10,10a-hexahydro-9h-dibenzo (b,d) pyran-9-one - Google Patents
Method of obtaining stable polymorphic form of 1-oxy-3-(1'1'-dimethylheptyl)-6,6-dimeth]-6,6a,8,10,10a-hexahydro-9h-dibenzo (b,d) pyran-9-oneInfo
- Publication number
- SU648101A3 SU648101A3 SU752130097A SU2130097A SU648101A3 SU 648101 A3 SU648101 A3 SU 648101A3 SU 752130097 A SU752130097 A SU 752130097A SU 2130097 A SU2130097 A SU 2130097A SU 648101 A3 SU648101 A3 SU 648101A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- hexahydro
- dimethylheptyl
- dibenzo
- pyran
- polymorphic form
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Изобретение относитс к новому спо собу получени новой стабильной, полиморфной формы 1-окси-З-(, l-диметилгептил )-6,6-диметил-6,6а,7,8,10, 10а-гексагидро-9Н-дибензо(B,d) пиран-9-она . Это соединение обладает ценными физиологически активными свойствами . Известны 1-окси-3-алкил-6,6-диметил-6 ,6а,7,8,10,10а-гексагидро-9Н-дибензо (B,dl пираноны-9, в частности 1-окси-З-(, l -диметилгептил)-б, 6-диметил-6 ,6а,7,8,10,10а-гексагидро-9Н-дибензо (B,d) пиран-9-он, которые очень плохо растворимы в воде, поэтому фармакологическое действие этих соединений затруднено Эти соединени могут существовать в твердом состо ни и в нескольких полиморфных формах, ко торые нестабильны 1. Цель изобретени - получение новой стабильной полиморфной формы 1-окси-3 (1, l -диметилгептил) 6,6-диметил-6 ,6а,7,8,10,10а-гексагидро-9Н-дибенэ ( B,d) пиран-9-она, с улучшенными биологически активными свойствами. Указанна цель достигаетс тем, что выпаривают растворитель из раствора 1 г 1-окси-З-(, l -диметилгептил )-6, 6-диметил-6, 6а,7,8,10,Юа-гексагидро-9Н-дибензо (B,d) пиран-9-она в 25 мл этанола при 20-30С. Полиморфна форма, полученна предлагаемым способом показывает двойное лучепреломление под пол ризационным микроскопом и эндопики при дифференциально-термическом анализе при 156 и 162 и имеет следующую порошковую рентгенограмму при использовании отфильтрованного хромового излучени с длиной волны А 2,289 А. оС в А ( межплоскостные рассто ни ) 14,5100 10,530 8,460 7,240 6,6020 5,9030 4,8560 4,1005 3,9040 3,3530 Пример 1. Раствор 1 г 1-окси-3- (1 , l -диметилгептил)-6, 6-диметил-6 ,6а,7,8,10,1Оа-гексагидро-9Н-дибeнзo (в,d)riиpaн-9-oнa в 25 мл этилового спирта помещают в роторный испаритель . Испаритель помещают в поддерживаемую при 20-30 0 вод ную банюThe invention relates to a novel process for the preparation of a new stable, polymorphic form of 1-hydroxy-3- (, l-dimethylheptyl) -6,6-dimethyl-6,6a, 7,8,10, 10a-hexahydro-9H-dibenzo (B , d) Piran-9-she. This compound has valuable physiologically active properties. Known 1-hydroxy-3-alkyl-6,6-dimethyl-6, 6a, 7,8,10,10a-hexahydro-9H-dibenzo (B, dl pyranones-9, in particular 1-hydroxy-3- (, l-dimethylheptyl) -b, 6-dimethyl-6, 6a, 7,8,10,10a-hexahydro-9H-dibenzo (B, d) pyran-9-one, which are very poorly soluble in water, therefore the pharmacological action of these Compounds difficult These compounds can exist in a solid state and in several polymorphic forms that are unstable. 1. The purpose of the invention is to obtain a new stable polymorphic form of 1-hydroxy-3 (1, l-dimethylheptyl) 6,6-dimethyl-6, 6a , 7,8,10,10a-hexahydro-9H-dibene (B, d) pyran-9-one, with improvement biologically active properties. This goal is achieved by evaporating the solvent from a solution of 1 g of 1-hydroxy-3- (, l-dimethylheptyl) -6, 6-dimethyl-6, 6a, 7,8,10, Yu-hexahydro 9H-dibenzo (B, d) pyran-9-one in 25 ml of ethanol at 20-30 C. The polymorphic form obtained by the proposed method shows birefringence under a polarization microscope and endopics in differential thermal analysis at 156 and 162 and has the following powder radiograph using filtered chromium radiation with a wavelength of A 2.289 A. oC A (interplanar spacing) 14.5100 10.530 8.460 7.240 6.6020 5.9030 4.8560 4.1005 3.9040 3.3530 Example 1. A solution of 1 g of 1-hydroxy-3- (1, l-dimethylheptyl) - 6, 6-dimethyl-6, 6a, 7,8,10,1Oa-hexahydro-9H-dibenzo (c, d) riiran-9-one in 25 ml of ethyl alcohol is placed in a rotary evaporator. The evaporator is placed in a water bath maintained at 20-30 0
и раствор выпаривают досуха, получа дибензрпиранан с полиморфной формой , имеющей п)йведённые выше свойства . , and the solution is evaporated to dryness, to give a dibenzrpyranane with a polymorphic form having n) the properties given above. ,
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50439174A | 1974-09-11 | 1974-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU648101A3 true SU648101A3 (en) | 1979-02-15 |
Family
ID=24006075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU752130097A SU648101A3 (en) | 1974-09-11 | 1975-05-06 | Method of obtaining stable polymorphic form of 1-oxy-3-(1'1'-dimethylheptyl)-6,6-dimeth]-6,6a,8,10,10a-hexahydro-9h-dibenzo (b,d) pyran-9-one |
Country Status (3)
| Country | Link |
|---|---|
| DK (1) | DK136649B (en) |
| RO (1) | RO71765A (en) |
| SU (1) | SU648101A3 (en) |
-
1974
- 1974-10-23 DK DK555674A patent/DK136649B/en not_active IP Right Cessation
- 1974-11-12 RO RO7480474A patent/RO71765A/en unknown
-
1975
- 1975-05-06 SU SU752130097A patent/SU648101A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DK136649B (en) | 1977-11-07 |
| DK136649C (en) | 1978-04-10 |
| DK555674A (en) | 1976-03-12 |
| RO71765A (en) | 1982-03-24 |
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