SU552744A1 - Method of preparing soluble pertussoid immunologic adjuvant - Google Patents
Method of preparing soluble pertussoid immunologic adjuvantInfo
- Publication number
- SU552744A1 SU552744A1 SU7502303724A SU2303724A SU552744A1 SU 552744 A1 SU552744 A1 SU 552744A1 SU 7502303724 A SU7502303724 A SU 7502303724A SU 2303724 A SU2303724 A SU 2303724A SU 552744 A1 SU552744 A1 SU 552744A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- pertussoid
- immunologic adjuvant
- preparing soluble
- fractionation
- carried out
- Prior art date
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
-:; ..- - ,; ,---- . ф-Ч- .- :; ..- -,; , ---- f-h-
г« i - . Vr «i -. V
552744552744
фера в надмембранную Фракцию подают дистиллированную воду, после чего надмембранную фракцию концентрируют, прогревают при 55-65°С в течение 2030 мин и лиофилизируют.the ferra is fed to the supramembrane fraction and distilled water is added, after which the supermembrane fraction is concentrated, heated at 55-65 ° C for 2030 minutes, and lyophilized.
Относительна адъювантна .активность препарата,полученного предлагаемым способом, в 5 раз выше корпускул рной коклюшной вакцины. Дл достижени равного иммуноадъювантного эффекта предлагаемого препарата доза может быть снижена в 5 раз. Токсичность , .гистамин-сенсибилиэирующа и реагин-стимулирующа активности снижены в Юг50 раз.The relative adjuvant activity of the preparation obtained by the proposed method is 5 times higher than the particulate pertussis vaccine. To achieve an equal immunoadjuvant effect of the proposed drug, the dose can be reduced by 5 times. Toxicity, histamine-sensitizing and reagin-stimulating activities are reduced by 50 times.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU7502303724A SU552744A1 (en) | 1975-12-25 | 1975-12-25 | Method of preparing soluble pertussoid immunologic adjuvant |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU7502303724A SU552744A1 (en) | 1975-12-25 | 1975-12-25 | Method of preparing soluble pertussoid immunologic adjuvant |
Publications (1)
Publication Number | Publication Date |
---|---|
SU552744A1 true SU552744A1 (en) | 1977-11-05 |
Family
ID=20642080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU7502303724A SU552744A1 (en) | 1975-12-25 | 1975-12-25 | Method of preparing soluble pertussoid immunologic adjuvant |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU552744A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4726947A (en) * | 1978-03-10 | 1988-02-23 | Matsui Toatsu Chemicals, Inc. | Bacterial cell extract, process for preparing same, antitumor preparation containing same, and adjuvant preparation containing same |
EA021618B1 (en) * | 2011-07-19 | 2015-07-30 | Игорь Закванович Зайцев | Adjuvant-free corpuscular vaccine and method for producing same |
-
1975
- 1975-12-25 SU SU7502303724A patent/SU552744A1/en active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4726947A (en) * | 1978-03-10 | 1988-02-23 | Matsui Toatsu Chemicals, Inc. | Bacterial cell extract, process for preparing same, antitumor preparation containing same, and adjuvant preparation containing same |
EA021618B1 (en) * | 2011-07-19 | 2015-07-30 | Игорь Закванович Зайцев | Adjuvant-free corpuscular vaccine and method for producing same |
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