SU513973A1 - The method of obtaining 1- (3 "-phenylpropene2" -yl) -2,5-dimethyl-4-phenyl-4-propionyloxypiperidine or its hydrochloride - Google Patents

The method of obtaining 1- (3 "-phenylpropene2" -yl) -2,5-dimethyl-4-phenyl-4-propionyloxypiperidine or its hydrochloride

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Publication number
SU513973A1
SU513973A1 SU2018964A SU2018964A SU513973A1 SU 513973 A1 SU513973 A1 SU 513973A1 SU 2018964 A SU2018964 A SU 2018964A SU 2018964 A SU2018964 A SU 2018964A SU 513973 A1 SU513973 A1 SU 513973A1
Authority
SU
USSR - Soviet Union
Prior art keywords
hydrochloride
dimethyl
phenyl
propionyloxypiperidine
obtaining
Prior art date
Application number
SU2018964A
Other languages
Russian (ru)
Inventor
Дмитрий Васильевич Соколов
Мария Никандровна Акимова
Калдыбек Джайловович Пралиев
Валентина Михайловна Куриленко
Жанна Николаевна Хлиенко
Original Assignee
Институт химических наук АН Казахской ССР
Новокузнецкий научно-исследовательский химико-фармацевтический институт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Институт химических наук АН Казахской ССР, Новокузнецкий научно-исследовательский химико-фармацевтический институт filed Critical Институт химических наук АН Казахской ССР
Priority to SU2018964A priority Critical patent/SU513973A1/en
Application granted granted Critical
Publication of SU513973A1 publication Critical patent/SU513973A1/en

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  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

катализатор отфильтровывают и промывают гор чим этанолом. Спиртовый раствор упаривают и кристаллизацией масл нистого остатка из петролейного эфира получают 1,00 г (66%) указаииого продукта с т. пл. 109-110°С, Rf 0,68 (эфир : петролейный эфир 1 : 2).the catalyst is filtered off and washed with hot ethanol. The alcoholic solution is evaporated and 1.00 g (66%) of the title product with m.p. 109-110 ° C, Rf 0.68 (ether: petroleum ether 1: 2).

Найдено, %: С 79,83; 79,88; Н 8,66: 8,35; N 3,70; 3,73.Found,%: C 79.83; 79.88; H 8.66: 8.35; N 3.70; 3.73.

C25H3lN02.C25H3lN02.

Вычислено, .%: С 79,60; Н 8,27; N 3,70.Calculated,%: C 79.60; H 8.27; N 3.70.

Гидрохлорид получают с 97%-ным выходом обработкой основани  эфирным раствором хлористого водорода. Он выдел етс  в виде мелких бесцветных кристаллов с т. пл. 192-193°С (из этилацетата).The hydrochloride is obtained in 97% yield by treating the base with an ethereal solution of hydrogen chloride. It is isolated in the form of small, colorless crystals with a m.p. 192-193 ° C (from ethyl acetate).

Найдено, %: С 72,35; 72,67; Н 7,70; 7,71; N 3,24; 3,04; С1 18,40; 8,48.Found,%: C 72.35; 72.67; H 7.70; 7.71; N 3.24; 3.04; C1 18.40; 8.48.

C2 H32C1N02C2 H32C1N02

Вычислено, Calculated

С 72,53; Н 7,79; N 3,38; С1 8,56.C, 72.53; H 7.79; N 3.38; C1 8.56.

Claims (1)

Формула изобретени Invention Formula Способ получени  1-(3-фенилпропен-2-ил)2 ,5-диметил-4-фенил-4 - пропионилоксипиперидипа или его гидрохлорида, отличающийСИ тем, что, с целью упрощени  процесса, повышени  выхода и чистоты целевого продукта, 1-(3-фенилпропин-2-ил) - 2,5 диметил - 4-фенил-4-пропионилоксипиперидин гидрируют в присутствии 5%-ного палладиевого катализатора , нанесенного на карбонат кальци , с последующим выделением целевого продукта в виде основани  или гидрохлорида.The method of obtaining 1- (3-phenylpropen-2-yl) 2, 5-dimethyl-4-phenyl-4 - propionyloxypiperidip or its hydrochloride, characterized in that, in order to simplify the process, increase the yield and purity of the target product, 1- ( 3-phenylpropin-2-yl) -2,5 dimethyl-4-phenyl-4-propionyloxypiperidine is hydrogenated in the presence of a 5% palladium catalyst supported on calcium carbonate, followed by isolation of the desired product as a base or hydrochloride.
SU2018964A 1974-04-19 1974-04-19 The method of obtaining 1- (3 "-phenylpropene2" -yl) -2,5-dimethyl-4-phenyl-4-propionyloxypiperidine or its hydrochloride SU513973A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU2018964A SU513973A1 (en) 1974-04-19 1974-04-19 The method of obtaining 1- (3 "-phenylpropene2" -yl) -2,5-dimethyl-4-phenyl-4-propionyloxypiperidine or its hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU2018964A SU513973A1 (en) 1974-04-19 1974-04-19 The method of obtaining 1- (3 "-phenylpropene2" -yl) -2,5-dimethyl-4-phenyl-4-propionyloxypiperidine or its hydrochloride

Publications (1)

Publication Number Publication Date
SU513973A1 true SU513973A1 (en) 1976-05-15

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SU2018964A SU513973A1 (en) 1974-04-19 1974-04-19 The method of obtaining 1- (3 "-phenylpropene2" -yl) -2,5-dimethyl-4-phenyl-4-propionyloxypiperidine or its hydrochloride

Country Status (1)

Country Link
SU (1) SU513973A1 (en)

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