SU509046A1 - Derivatives of 2-carbethoxy-3-aminoindole having antiinflammatory effect and process for preparing same - Google Patents
Derivatives of 2-carbethoxy-3-aminoindole having antiinflammatory effect and process for preparing same Download PDFInfo
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- SU509046A1 SU509046A1 SU752106704A SU2106704A SU509046A1 SU 509046 A1 SU509046 A1 SU 509046A1 SU 752106704 A SU752106704 A SU 752106704A SU 2106704 A SU2106704 A SU 2106704A SU 509046 A1 SU509046 A1 SU 509046A1
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- aminoindole
- derivatives
- carbethoxy
- alkyl
- hydrogen
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Abstract
1. Производные 2-карбэтокси-З- -аминоиндола общей формулы I:где R' - водород, алкил, алкоксигруп-па, галоген; R - .водород, алкил,про вл ющие противовоспалительную активность.2. Способ получени производных 2гкарбзтокси-3-аминоиндола,-о тли-' чающийс тем, что соединени общей формулы 1. Derivatives of 2-carbethoxy-3-α-aminoindole of the general formula I: where R 'is hydrogen, alkyl, alkoxygroup, halogen; R - hydrogen, alkyl, exhibiting anti-inflammatory activity. The method of obtaining the derivatives of 2g carbaztoxy-3-aminoindole, -o tly-, due to the fact that the compounds of the general formula
Description
Изобретение относитс к новым химическим соединени м, а именно к производным 2-карбэтокси-З-аминоиндола общей формулы (1):The invention relates to new chemical compounds, namely, to derivatives of 2-carbethoxy-3-aminoindole of the general formula (1):
(I)(I)
COOCzHsCOOCzHs
гдеWhere
алкоксигруппа , галоген,alkoxy group, halogen,
Эти соединени обладают выраженной противовоспалительной активностью, превосход щей активность противовоспалительного препарата бутадион.These compounds have a pronounced anti-inflammatory activity, superior to the activity of the anti-inflammatory drug butadione.
Противовоспалительное действие было изучено на нелинейных крысах при хроническом пролиферативном воспалении , вызванном введением под Ko-i жу живота инородных тел и при остром The anti-inflammatory effect was studied in non-linear rats in chronic proliferative inflammation caused by the introduction of foreign bodies under the Ko-i stomach and in acute
экссудативном воспалении, вызванном введением в плевральную или брюганую полость 0,25% раствора азотнокислого серебра.exudative inflammation caused by the introduction of a 0.25% solution of silver nitrate into the pleural or brutic cavity.
Все препараты вводили внутрь через зонд в желудок в виде водной взвеси в дозе 100 мг/кг. При лечении хронического воспалени препарат вводили в день имплатации инородного тела и в последующие 6 дней. На 8-й день животных забивали.All drugs were injected through the probe into the stomach in the form of an aqueous suspension at a dose of 100 mg / kg. In the treatment of chronic inflammation, the drug was administered on the day of implantation of a foreign body and for the next 6 days. On the 8th day the animals were killed.
Показателем интенсивности воспалительного процесса вл лс вес образовавшихс гранулем. При остром воспалении препараты вводили однократно за 30 мин до введени азотнокислого серебра. Через 6 ч после введени азотнокислого серебра животных забивали . Интенсивность воспалительного процесса определ ли по количеству экссудата в полости. Результаты приведены в таблице.An indicator of the intensity of the inflammatory process was the weight of the formed granulomas. For acute inflammation, the drugs were administered once 30 minutes before the introduction of silver nitrate. Six hours after the introduction of silver nitrate, the animals were killed. The intensity of the inflammatory process was determined by the amount of exudate in the cavity. The results are shown in the table.
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Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU752106704A SU509046A1 (en) | 1975-02-21 | 1975-02-21 | Derivatives of 2-carbethoxy-3-aminoindole having antiinflammatory effect and process for preparing same |
Applications Claiming Priority (1)
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SU752106704A SU509046A1 (en) | 1975-02-21 | 1975-02-21 | Derivatives of 2-carbethoxy-3-aminoindole having antiinflammatory effect and process for preparing same |
Publications (1)
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SU509046A1 true SU509046A1 (en) | 1984-06-23 |
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SU752106704A SU509046A1 (en) | 1975-02-21 | 1975-02-21 | Derivatives of 2-carbethoxy-3-aminoindole having antiinflammatory effect and process for preparing same |
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Cited By (5)
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JP2008542291A (en) * | 2005-05-26 | 2008-11-27 | ニューロン システムズ | Compositions and methods for treating retinal diseases |
US9604997B2 (en) | 2012-12-20 | 2017-03-28 | Aldeyra Therapeutics, Inc. | Peri-carbinols |
US9687481B2 (en) | 2013-01-23 | 2017-06-27 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
US10111862B2 (en) | 2013-01-25 | 2018-10-30 | Aldeyra Therapeutics, Inc. | Traps in the treatment of macular degeneration |
US10414732B2 (en) | 2017-03-16 | 2019-09-17 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
-
1975
- 1975-02-21 SU SU752106704A patent/SU509046A1/en active
Cited By (14)
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US9650342B2 (en) | 2005-05-26 | 2017-05-16 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
JP2008542291A (en) * | 2005-05-26 | 2008-11-27 | ニューロン システムズ | Compositions and methods for treating retinal diseases |
US8940721B2 (en) | 2005-05-26 | 2015-01-27 | Aldexa Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US9265759B2 (en) | 2005-05-26 | 2016-02-23 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US9364471B2 (en) | 2005-05-26 | 2016-06-14 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US10913722B2 (en) | 2005-05-26 | 2021-02-09 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US8940764B2 (en) | 2005-05-26 | 2015-01-27 | Aldexa Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US9896419B2 (en) | 2005-05-26 | 2018-02-20 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US10202348B2 (en) | 2005-05-26 | 2019-02-12 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US9604997B2 (en) | 2012-12-20 | 2017-03-28 | Aldeyra Therapeutics, Inc. | Peri-carbinols |
US9687481B2 (en) | 2013-01-23 | 2017-06-27 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
US10213395B2 (en) | 2013-01-23 | 2019-02-26 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
US10111862B2 (en) | 2013-01-25 | 2018-10-30 | Aldeyra Therapeutics, Inc. | Traps in the treatment of macular degeneration |
US10414732B2 (en) | 2017-03-16 | 2019-09-17 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
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