SU487076A1 - The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives - Google Patents

The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives

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Publication number
SU487076A1
SU487076A1 SU2025295A SU2025295A SU487076A1 SU 487076 A1 SU487076 A1 SU 487076A1 SU 2025295 A SU2025295 A SU 2025295A SU 2025295 A SU2025295 A SU 2025295A SU 487076 A1 SU487076 A1 SU 487076A1
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SU
USSR - Soviet Union
Prior art keywords
pyrilya
pyrimidine derivatives
obtaining salts
salts
acid
Prior art date
Application number
SU2025295A
Other languages
Russian (ru)
Inventor
Виталий Афанасьевич Чуйгук
Наталья Николаевна Власова
Original Assignee
Киевский Ордена Ленина Государственный Университет Им.Т.Г. Шевченко
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Киевский Ордена Ленина Государственный Университет Им.Т.Г. Шевченко filed Critical Киевский Ордена Ленина Государственный Университет Им.Т.Г. Шевченко
Priority to SU2025295A priority Critical patent/SU487076A1/en
Application granted granted Critical
Publication of SU487076A1 publication Critical patent/SU487076A1/en

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Description

дают пиридо-(2,3-с/)-пиримидины и их четвертичные соли.give pyrido (2,3-c /) - pyrimidines and their quaternary salts.

Пример. Смесь 0,004 моль соответствующего производного 4,6-диоксипиримидина и 0,0044 моль р-дикетона нагревают определенное врем  иа вод ной бане.Example. A mixture of 0.004 mol of the corresponding 4,6-dioxypyrimidine derivative and 0.0044 mol of p-diketone is heated for a certain time in a water bath.

По окончании реакции при использовании ацетилацетона и безводной смеси уксуспой и хлорной кислот (0,236 г хлорной кислоты в 1 мл смеси) через 5-15 мин выпадает осадок, который перекристаллизовьгвают «з соответствующего растворител . При использовании 35%-ной фосфорной кислоты продукт осаждают эфиром и очищают переосаждепием эфиром из трифторуксусной кислоты. При применении трифторуксусной кислоты продукт после осаждени  эфиром перекристаллизовывают из уксусной кислоты. При проведении реакции с дибензоилметаном осадок выпадает через 30-35 мин после ее окончани . Результаты опытов сведены в таблицу.At the end of the reaction, when using acetylacetone and anhydrous mixture of uxusp and perchloric acid (0.236 g of perchloric acid in 1 ml of the mixture) a precipitate is formed after 5-15 min, which is recrystallized “from the corresponding solvent. When using 35% phosphoric acid, the product is precipitated with ether and purified by re-precipitating with trifluoroacetic acid ether. When trifluoroacetic acid is used, the product after precipitation with ether is recrystallized from acetic acid. When the reaction is carried out with dibenzoylmethane, the precipitate falls 30 to 35 minutes after its termination. The results of the experiments are tabulated.

где R - алкил или арил; Ri - окси-, меркапто- или аминогруппа; А - остаток кислоты, отличающийс  тем, что производное 4,6диоксипиримидина общей формулыwhere R is alkyl or aryl; Ri is hydroxy, mercapto or amino; A is an acid residue, characterized in that the 4,6-dioxypyrimidine derivative of the general formula

- R,- R,

н-Оbut

где RI - как указано выше, подвергают взаимодействию с р-дикетоном общей формулыwhere RI is as indicated above, is reacted with the p-diketone of the general formula

, ,

:СИо: Sio

Предмет изобретени Subject invention

1. Способ получени  солей производных пирилиа- 2 ,3-й чпиримидина общей формулы1. A process for the preparation of salts of pyrilium derivatives of 2, 3rd pyrimidine of the general formula

25 где R имеет выщеуказанные значени , в присутствии соответствующей кислоты при нагревании и выдел ют целевой продукт известными приемами.25 where R has the values indicated above, in the presence of an appropriate acid when heated, and isolate the desired product by known techniques.

SU2025295A 1974-05-17 1974-05-17 The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives SU487076A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU2025295A SU487076A1 (en) 1974-05-17 1974-05-17 The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU2025295A SU487076A1 (en) 1974-05-17 1974-05-17 The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives

Publications (1)

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SU487076A1 true SU487076A1 (en) 1975-10-05

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SU (1) SU487076A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025718A1 (en) * 1997-11-19 1999-05-27 Tets, Viktor Veniaminovich 5H-PYRANO[2,3-d:6,5-d']DIPYRIMIDINE DERIVATIVES HAVING AN ANTIBACTERIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025718A1 (en) * 1997-11-19 1999-05-27 Tets, Viktor Veniaminovich 5H-PYRANO[2,3-d:6,5-d']DIPYRIMIDINE DERIVATIVES HAVING AN ANTIBACTERIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY

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