SU487076A1 - The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives - Google Patents
The method of obtaining salts of pyrilya (2,3-) pyrimidine derivativesInfo
- Publication number
- SU487076A1 SU487076A1 SU2025295A SU2025295A SU487076A1 SU 487076 A1 SU487076 A1 SU 487076A1 SU 2025295 A SU2025295 A SU 2025295A SU 2025295 A SU2025295 A SU 2025295A SU 487076 A1 SU487076 A1 SU 487076A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- pyrilya
- pyrimidine derivatives
- obtaining salts
- salts
- acid
- Prior art date
Links
Description
дают пиридо-(2,3-с/)-пиримидины и их четвертичные соли.give pyrido (2,3-c /) - pyrimidines and their quaternary salts.
Пример. Смесь 0,004 моль соответствующего производного 4,6-диоксипиримидина и 0,0044 моль р-дикетона нагревают определенное врем иа вод ной бане.Example. A mixture of 0.004 mol of the corresponding 4,6-dioxypyrimidine derivative and 0.0044 mol of p-diketone is heated for a certain time in a water bath.
По окончании реакции при использовании ацетилацетона и безводной смеси уксуспой и хлорной кислот (0,236 г хлорной кислоты в 1 мл смеси) через 5-15 мин выпадает осадок, который перекристаллизовьгвают «з соответствующего растворител . При использовании 35%-ной фосфорной кислоты продукт осаждают эфиром и очищают переосаждепием эфиром из трифторуксусной кислоты. При применении трифторуксусной кислоты продукт после осаждени эфиром перекристаллизовывают из уксусной кислоты. При проведении реакции с дибензоилметаном осадок выпадает через 30-35 мин после ее окончани . Результаты опытов сведены в таблицу.At the end of the reaction, when using acetylacetone and anhydrous mixture of uxusp and perchloric acid (0.236 g of perchloric acid in 1 ml of the mixture) a precipitate is formed after 5-15 min, which is recrystallized “from the corresponding solvent. When using 35% phosphoric acid, the product is precipitated with ether and purified by re-precipitating with trifluoroacetic acid ether. When trifluoroacetic acid is used, the product after precipitation with ether is recrystallized from acetic acid. When the reaction is carried out with dibenzoylmethane, the precipitate falls 30 to 35 minutes after its termination. The results of the experiments are tabulated.
где R - алкил или арил; Ri - окси-, меркапто- или аминогруппа; А - остаток кислоты, отличающийс тем, что производное 4,6диоксипиримидина общей формулыwhere R is alkyl or aryl; Ri is hydroxy, mercapto or amino; A is an acid residue, characterized in that the 4,6-dioxypyrimidine derivative of the general formula
- R,- R,
н-Оbut
где RI - как указано выше, подвергают взаимодействию с р-дикетоном общей формулыwhere RI is as indicated above, is reacted with the p-diketone of the general formula
, ,
:СИо: Sio
Предмет изобретени Subject invention
1. Способ получени солей производных пирилиа- 2 ,3-й чпиримидина общей формулы1. A process for the preparation of salts of pyrilium derivatives of 2, 3rd pyrimidine of the general formula
25 где R имеет выщеуказанные значени , в присутствии соответствующей кислоты при нагревании и выдел ют целевой продукт известными приемами.25 where R has the values indicated above, in the presence of an appropriate acid when heated, and isolate the desired product by known techniques.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU2025295A SU487076A1 (en) | 1974-05-17 | 1974-05-17 | The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU2025295A SU487076A1 (en) | 1974-05-17 | 1974-05-17 | The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SU487076A1 true SU487076A1 (en) | 1975-10-05 |
Family
ID=20584871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU2025295A SU487076A1 (en) | 1974-05-17 | 1974-05-17 | The method of obtaining salts of pyrilya (2,3-) pyrimidine derivatives |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU487076A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999025718A1 (en) * | 1997-11-19 | 1999-05-27 | Tets, Viktor Veniaminovich | 5H-PYRANO[2,3-d:6,5-d']DIPYRIMIDINE DERIVATIVES HAVING AN ANTIBACTERIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY |
-
1974
- 1974-05-17 SU SU2025295A patent/SU487076A1/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999025718A1 (en) * | 1997-11-19 | 1999-05-27 | Tets, Viktor Veniaminovich | 5H-PYRANO[2,3-d:6,5-d']DIPYRIMIDINE DERIVATIVES HAVING AN ANTIBACTERIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY |
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