SU384819A1 - METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES - Google Patents

METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES

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Publication number
SU384819A1
SU384819A1 SU1644481A SU1644481A SU384819A1 SU 384819 A1 SU384819 A1 SU 384819A1 SU 1644481 A SU1644481 A SU 1644481A SU 1644481 A SU1644481 A SU 1644481A SU 384819 A1 SU384819 A1 SU 384819A1
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SU
USSR - Soviet Union
Prior art keywords
derivatives
imidazolidones
producing
dialkyl
bromine
Prior art date
Application number
SU1644481A
Other languages
Russian (ru)
Inventor
изоб ретени ары
Original Assignee
Ю. В. Мелика, И. Смоланка, В. И. Станинец , В. С. Петрус Ужгородский государственный университет
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ю. В. Мелика, И. Смоланка, В. И. Станинец , В. С. Петрус Ужгородский государственный университет filed Critical Ю. В. Мелика, И. Смоланка, В. И. Станинец , В. С. Петрус Ужгородский государственный университет
Priority to SU1644481A priority Critical patent/SU384819A1/en
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Publication of SU384819A1 publication Critical patent/SU384819A1/en

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Изобретеиие относитс  к способу .получени  производных 1,3-1ими1дазол Идонов-5, о1бладающих б.иолЮ|ПическОй активностью. Известен опособ лолучени  производных 4(5)-лиа8ОЛ1идона цИ1кл;изацией авдидов М-тиоаадил-а , р-напредельных кислот под действием брома. OoHiaB.aHHbm на ИЗВЕСТНОЙ реакции тред чагаамый апособ получени  троизвосцных 1,3 .и МИД а золи донов-5 общей бор1мулы fbi, где R - N(CHj),-, ЖС2Н),-, У( N. О X - галоид, (Предпочтительно бром, йод, заключаетс  в том, что Ы,Н-диалкил-(диар1ил )-ами1НО|метилами1Ды акриловой кислоты галолдируют в ареде органического растворител , Например хлорофор-ма, при охлаждении и выдел ют целавой продуз т известным способом . Исходные N, Н-диалкил- () -aiM«Ho/Meтила-миды акриловой кислоты не описаны в литературе и получены авторами из а,мида а1кр1иловой КИСЛОТЫ, форм.али:на, диалкила:МИнсв или пиперидина 1и морф;ол1ина по реакции М анниха. П р И -м е р 1. 3,3-Диметил-4-бромметил1 ,3-И1мидазол.идо1Н-5-КЙбрО1Мид. В круглодс.Н1Н|ую колбу, снабженную обратным холоДильни:кО|М, «апельной воронкой и механ1Ичеакой мешалкай, помещают 10,7 г (0,08 моль) Ы,К-|ДИметила1м;инометилаМида акриловой кислоты В 25 мл хлороформа, прл сильном ОХла1ЖдвН1И,и н П1ере ме,Ш.ивании прибавл ют 1ПО капл м 12,8 г (0,08 моль) брома, pacTBQpeHHoro в 25 мл хлороформа, перемеШнвают 2 час трт ко-мнатной те,мЛе|ратуре, вьшадаЮ|Щ1ие желтые .кристаллы отфильт)ровывают и перекристалливовывлют из спирта. Выход 15 г (72%), т. 71л. 171° С Найдено, %1: N 9,61; 9,31; Вг 27,64; 27,51; Вг Вг 54,44; 54,11. CeHi BrsNjO.The invention relates to a method of obtaining derivatives of 1.3-1 and 1-dazole Idonov-5, having 1) | My own | physical activity. A known method of obtaining the derivatives of 4 (5) -l-8OL1idone CI1Cl; isotation of the avidides M-thioadyl-a, p-naline acids under the action of bromine. OoHiaB.aHHbm on the KNOWN reaction of the thread chagaam apoproof of obtaining threefold 1,3 .and MFA and sol don-5 common borm1 fbi, where R is N (CHj), -, ЖС2Н), -, У (N. О X - halogen, (Preferably, bromine, iodine, consists in that L, H-dialkyl- (diarl) -ami1NO | methylamides 1DY acrylic acid is galledate in an arened organic solvent, e.g. , N-dialkyl- () -aiM “Ho / Methyl-amides of acrylic acid are not described in the literature and are obtained by the authors from a, mida a1cr1ilic acid, formuli, or on: dialkyl: Min. St or piperidine 1i and morph; ol1ina by the reaction of M annic. Pp I-m r 1. 3,3-Dimethyl-4-bromomethyl1, 3-I1midazole.ido1H-5-Cybro1Mid. In round glass.H1N | th flask equipped with reverse holodilni: kO | M, “funnel and mechanically mixed agitators”, placed 10.7 g (0.08 mol) N, K- | Dimethyl1m; inmetylMidary of acrylic acid 25 ml of chloroform, shielded OXL1HdvNII, and Pryre me In addition, 1PO droplets of 12.8 g (0.08 mol) of bromine, pacTBQpeHHoro in 25 ml of chloroform were added, stirred for 2 hours at room temperature, above, and the yellow crystals were filtered out and recrystallized from alcohol. Yield 15 g (72%), t. 71l. 171 ° C. Found 1%: N 9.61; 9.31; Br 27.64; 27.51; Br Br 54.44; 54.11. CeHi BrsNjO.

SU1644481A 1971-04-01 1971-04-01 METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES SU384819A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU1644481A SU384819A1 (en) 1971-04-01 1971-04-01 METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1644481A SU384819A1 (en) 1971-04-01 1971-04-01 METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES

Publications (1)

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SU384819A1 true SU384819A1 (en) 1973-05-29

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