SU384819A1 - METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES - Google Patents
METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVESInfo
- Publication number
- SU384819A1 SU384819A1 SU1644481A SU1644481A SU384819A1 SU 384819 A1 SU384819 A1 SU 384819A1 SU 1644481 A SU1644481 A SU 1644481A SU 1644481 A SU1644481 A SU 1644481A SU 384819 A1 SU384819 A1 SU 384819A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- derivatives
- imidazolidones
- producing
- dialkyl
- bromine
- Prior art date
Links
Description
Изобретеиие относитс к способу .получени производных 1,3-1ими1дазол Идонов-5, о1бладающих б.иолЮ|ПическОй активностью. Известен опособ лолучени производных 4(5)-лиа8ОЛ1идона цИ1кл;изацией авдидов М-тиоаадил-а , р-напредельных кислот под действием брома. OoHiaB.aHHbm на ИЗВЕСТНОЙ реакции тред чагаамый апособ получени троизвосцных 1,3 .и МИД а золи донов-5 общей бор1мулы fbi, где R - N(CHj),-, ЖС2Н),-, У( N. О X - галоид, (Предпочтительно бром, йод, заключаетс в том, что Ы,Н-диалкил-(диар1ил )-ами1НО|метилами1Ды акриловой кислоты галолдируют в ареде органического растворител , Например хлорофор-ма, при охлаждении и выдел ют целавой продуз т известным способом . Исходные N, Н-диалкил- () -aiM«Ho/Meтила-миды акриловой кислоты не описаны в литературе и получены авторами из а,мида а1кр1иловой КИСЛОТЫ, форм.али:на, диалкила:МИнсв или пиперидина 1и морф;ол1ина по реакции М анниха. П р И -м е р 1. 3,3-Диметил-4-бромметил1 ,3-И1мидазол.идо1Н-5-КЙбрО1Мид. В круглодс.Н1Н|ую колбу, снабженную обратным холоДильни:кО|М, «апельной воронкой и механ1Ичеакой мешалкай, помещают 10,7 г (0,08 моль) Ы,К-|ДИметила1м;инометилаМида акриловой кислоты В 25 мл хлороформа, прл сильном ОХла1ЖдвН1И,и н П1ере ме,Ш.ивании прибавл ют 1ПО капл м 12,8 г (0,08 моль) брома, pacTBQpeHHoro в 25 мл хлороформа, перемеШнвают 2 час трт ко-мнатной те,мЛе|ратуре, вьшадаЮ|Щ1ие желтые .кристаллы отфильт)ровывают и перекристалливовывлют из спирта. Выход 15 г (72%), т. 71л. 171° С Найдено, %1: N 9,61; 9,31; Вг 27,64; 27,51; Вг Вг 54,44; 54,11. CeHi BrsNjO.The invention relates to a method of obtaining derivatives of 1.3-1 and 1-dazole Idonov-5, having 1) | My own | physical activity. A known method of obtaining the derivatives of 4 (5) -l-8OL1idone CI1Cl; isotation of the avidides M-thioadyl-a, p-naline acids under the action of bromine. OoHiaB.aHHbm on the KNOWN reaction of the thread chagaam apoproof of obtaining threefold 1,3 .and MFA and sol don-5 common borm1 fbi, where R is N (CHj), -, ЖС2Н), -, У (N. О X - halogen, (Preferably, bromine, iodine, consists in that L, H-dialkyl- (diarl) -ami1NO | methylamides 1DY acrylic acid is galledate in an arened organic solvent, e.g. , N-dialkyl- () -aiM “Ho / Methyl-amides of acrylic acid are not described in the literature and are obtained by the authors from a, mida a1cr1ilic acid, formuli, or on: dialkyl: Min. St or piperidine 1i and morph; ol1ina by the reaction of M annic. Pp I-m r 1. 3,3-Dimethyl-4-bromomethyl1, 3-I1midazole.ido1H-5-Cybro1Mid. In round glass.H1N | th flask equipped with reverse holodilni: kO | M, “funnel and mechanically mixed agitators”, placed 10.7 g (0.08 mol) N, K- | Dimethyl1m; inmetylMidary of acrylic acid 25 ml of chloroform, shielded OXL1HdvNII, and Pryre me In addition, 1PO droplets of 12.8 g (0.08 mol) of bromine, pacTBQpeHHoro in 25 ml of chloroform were added, stirred for 2 hours at room temperature, above, and the yellow crystals were filtered out and recrystallized from alcohol. Yield 15 g (72%), t. 71l. 171 ° C. Found 1%: N 9.61; 9.31; Br 27.64; 27.51; Br Br 54.44; 54.11. CeHi BrsNjO.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU1644481A SU384819A1 (en) | 1971-04-01 | 1971-04-01 | METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU1644481A SU384819A1 (en) | 1971-04-01 | 1971-04-01 | METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES |
Publications (1)
Publication Number | Publication Date |
---|---|
SU384819A1 true SU384819A1 (en) | 1973-05-29 |
Family
ID=20471775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU1644481A SU384819A1 (en) | 1971-04-01 | 1971-04-01 | METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU384819A1 (en) |
-
1971
- 1971-04-01 SU SU1644481A patent/SU384819A1/en active
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE7506292L (en) | N-SUBSTITUTED-14-HYDROXY-3-SUBSTITUTED-MORPHINE DERIVATIVES AND PROCEDURES FOR THE MANUFACTURE | |
SU384819A1 (en) | METHOD FOR PRODUCING 1,3-IMIDAZOLIDONES-5 DERIVATIVES | |
SU506298A3 (en) | The method of obtaining derivatives of izikhinolinteofillina | |
BE787842A (en) | PROCESS FOR PREPARING AN AQUEOUS SUSPENSION OF STABLE CRYSTALS OF THE NON-BETA TYPE OF HIGHER FATTY ACID ESTERS OF CHLORAMPHENICOL | |
BE815282A (en) | PROCESS FOR PREPARATION OF OXO-CARBOXYLIC ACID ESTERS | |
SU369116A1 (en) | METHOD OF OBTAINING SPIRO-R-DIKETOLAKTONOV OF INDANDIONAL SERIES | |
IT1010870B (en) | PROCESS FOR THE ME DIANT ELIMINATION OXIDATION OF IMPURITIES BY ACETIC ACID | |
SE404526B (en) | PROCEDURE FOR THE PREPARATION OF P-AMINOBENZOIC ACID | |
SU502896A1 (en) | The method of obtaining bis (priortilsilyl) sulfates | |
CH517061A (en) | Process for the production of manganic salt of aliphatic carboxylic acid | |
SU361173A1 (en) | WAY OF OBTAINING DERIVATIVES OF G: | |
SU415261A1 (en) | METHOD FOR OBTAINING 2-HALOGENPAPTALIN-1,4,5,8-TETRACARBONIC ACID BISIMID1 The invention relates to the production of new intermediate products, in particular 2-halo-naphthalene-1,4,5,8-tetracarbonic acid bisimide, which can be used in as biologically active preparations, and also as intermediates in the synthesis of dyes. A method is known for producing 2,6-dichloro-naphthalene tetracarboxylic acid bisimides by treating 2,6-dichloro-naphthalene tetracarboxylic acid with amines. Target products are not widely practiced and only recently have they been used in the production of blue dyes for dyeing polyester fiber in bulk. The proposed method, although based on the known reaction of the interaction of halogenaphthalene tetracarboxylic acids with amines, allows, however, to obtain new compounds on the basis of which better and cheaper dyes are obtained for chemical fibers. The method consists in the fact that 2-halogenated naphthalene-1,4,5,8-tetracarboxylic acid or its dianhydride is treated with t primary aliphatic, alicyclic or aromatic amine in an organic acid medium, such as acetic acid, at 50-120 ° C, followed by separation of the target product by known techniques. Bisimides of 2-halogeno-naphthal-1,4,5,5-tetracarboxylic acid of the general formula 1015 are obtained. 9 g of 2-chloro-naphthalene-1,4,5,8-tetracarboxylic acid dianhydride and 10 ml of 20 aniline are boiled for 3 hours in 135 ml of acetic acid, cooled, the precipitate is filtered off, washed with 20 ml of acetic acid and water, boil for 30 minutes in 100 ml of a 5% aqueous solution, draw, filter, wash are, su-25 chat. The yield of 2-chloronaphthalene-1,4,5,8-tetracarboxylic acid bisphenylimide is 11.7 g (95.3%). The product is obtained as small colorless needles that do not melt to 400 ° C. Found,%: N 6.48, 6.37; C1 7.93, 7.87.30 C2bN1zC1Y2O4. | |
SU487886A1 (en) | The method of obtaining 1 - chlorhexylcarbamoylbenzimidazolin-2-carbamates | |
SU471362A1 (en) | The method of obtaining 2-amino-4-phenyl-1,3,4-thiadiazepinone-5 | |
SU505639A1 (en) | The method of obtaining - / benzimidazolyl-2 / perfluorocarboxylic acids | |
SU479770A1 (en) | The method of obtaining-unsaturated ketones condensed imidazole systems | |
FR2446272A1 (en) | NOVEL SUBSTITUTED PENTEN-2-YLE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE SYNTHESIS OF A CHRYSANTHEMIC ACID PRECURSOR | |
SU462830A1 (en) | The method of obtaining phosphorus-containing 1-phenyl-5-methyltriazole-1,2,3 | |
SU371217A1 (en) | WAY OF OBTAINING 3,16-DIACETATE PREGNEN-5-TRIOL-Zr, 16a, 17a-SHE-20 | |
SU447409A1 (en) | Method for producing tetramethylethylenediphosphine dioxide | |
SU427016A1 (en) | METHOD FOR OBTAINING 4H-3,1-BENZOXAZIN-4-OH-2-CARBIC ACID AMIDES1 The invention relates to the preparation of the 4H-3,1-benzoxazin-4-one-2-amides - carboxylic acid. These amides are not described in the literature, their method of preparation is not known. Chemically, they are highly active compounds and are of interest as intermediates for organic sietez, including for the production of biologically active compounds. In particular, on the basis of these amides, amides of 4 (3H) -quinazolo; n-2-carboxylic acid can be obtained, which, according to literature data, represent HiHTOpec as drugs with P-vitamin activity. In the literature A 4N-3, .1-benzoxazn-4-one-2-carboxylic acid ester preparation method is known to react oxamoyl anthranilic acid ethyl ester with acetic anhydride, followed by isolation of the products by a known method. However, the 4H-3,1-benzoxazium-4-one-2-carboxylic acid amides, as the method of their preparation, were not previously known. A method for preparing the 4H-3,1-benzoxazip-4-one-2-carboxylic acid amides is proposed. of the general formula ICONHR10, where R is hydrogen, normal or isoalkyl, consisting in the fact that the amide of oxamoyl anthranilic acid of the general formula . Methylamide 4H-3,1-benzoxazip-4-one-2-carboxylic acid. 8 g of 1M-1 methyl-ox-M'OIyl "tra". Methyl acid (II, R-CH3) in 16 ml of acetic angndrum is heated under reflux. After 10 minutes from the start of heating, the acid is completely dissolved, heating is continued for another 10 minutes. Upon cooling, a precipitate is released. To the reaction mass was added 10 ml of absolute ether. Sediment filter | |
SU490797A1 (en) | The method of obtaining 2-arylaminopolyfluorobenzoic acids | |
SU487895A1 (en) | Method for preparing aryl esters aryl (alkylene) -byl-1-hydroxy-2,2,2-trichloroethylphosphinic acids | |
SU429061A1 (en) | METHOD OF OBTAINING 2- | |
SU1051096A1 (en) | Process for preparing arylphosphonic acid dichloroanhydrides |