SU382632A1 - METHOD OF OBTAINING 7-ALKYL-6- (NITROIMIDAZOLYL) THIOPURINS - Google Patents

METHOD OF OBTAINING 7-ALKYL-6- (NITROIMIDAZOLYL) THIOPURINS

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Publication number
SU382632A1
SU382632A1 SU1670505/04A SU1670505A SU382632A1 SU 382632 A1 SU382632 A1 SU 382632A1 SU 1670505/04 A SU1670505/04 A SU 1670505/04A SU 1670505 A SU1670505 A SU 1670505A SU 382632 A1 SU382632 A1 SU 382632A1
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SU
USSR - Soviet Union
Prior art keywords
alkyl
nitroimidazolyl
obtaining
lower alkyl
thiopurins
Prior art date
Application number
SU1670505/04A
Other languages
Russian (ru)
Inventor
П.М. Кочергин
В.С. Корсунский
В.С. Шлихунова
Original Assignee
Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе filed Critical Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе
Priority to SU1670505/04A priority Critical patent/SU382632A1/en
Application granted granted Critical
Publication of SU382632A1 publication Critical patent/SU382632A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Способ получения 7-алкил-6-(нитроимидазолил)тиопуринов общей формулы:где R- водород, галоген, диалкиламиногруппа;R- низший алкил;R- водород, низший алкил, окси-низший алкил, остаток глицерина;R- водород, низший алкил,или общей формулыгде R- водород, галоген, диалкиламиногруппа;R- низший алкил;R- водород;R- низший алкил,отличающийся тем, что, с целью упрощения процесса и расширения ассортимента получаемых продуктов, 6-галоген-7-алкилпурин или его двузамещенное производное подвергают взаимодействию с 1(или 2)-алкил(или 1,2-диалкил)-4(или 5)-нитро-5(или 4)-меркаптоимидазолом в среде растворителя в присутствии щелочного агента с последующим выделением целевого продукта известным способом.2. Способ по п.1, отличающийся тем, что в качестве растворителя применяют воду или спирт.1. The method of obtaining 7-alkyl-6- (nitroimidazolyl) thiopurines of the general formula: lower alkyl, or the general formula where R is hydrogen, halogen, dialkylamino; R is lower alkyl; R is hydrogen; R is lower alkyl, characterized in that, in order to simplify the process and expand the range of products obtained, 6-halogen-7-alkyl purity or its disubstituted derivative is reacted with 1 (or 2) -alkyl (or 1,2-dialkyl) -4 (or 5) -nitro-5 (or 4) -me rcaptoimidazole in the solvent in the presence of an alkaline agent, followed by separation of the target product in a known manner. The method according to claim 1, characterized in that water or alcohol is used as a solvent.

SU1670505/04A 1971-06-21 1971-06-21 METHOD OF OBTAINING 7-ALKYL-6- (NITROIMIDAZOLYL) THIOPURINS SU382632A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU1670505/04A SU382632A1 (en) 1971-06-21 1971-06-21 METHOD OF OBTAINING 7-ALKYL-6- (NITROIMIDAZOLYL) THIOPURINS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1670505/04A SU382632A1 (en) 1971-06-21 1971-06-21 METHOD OF OBTAINING 7-ALKYL-6- (NITROIMIDAZOLYL) THIOPURINS

Publications (1)

Publication Number Publication Date
SU382632A1 true SU382632A1 (en) 1999-08-27

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ID=60514105

Family Applications (1)

Application Number Title Priority Date Filing Date
SU1670505/04A SU382632A1 (en) 1971-06-21 1971-06-21 METHOD OF OBTAINING 7-ALKYL-6- (NITROIMIDAZOLYL) THIOPURINS

Country Status (1)

Country Link
SU (1) SU382632A1 (en)

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