SU380117A1 - The method of obtaining N-beta- [thio (phosphorylthioacetyl)] - hydrazides thiophosphoric acids - Google Patents

Description

 The isoretenpe belongs to the region of Lucep 1P: rii.Tpa34; jc) B thiophosphoric; acids, and kms «0 to the demolition of the retrieved memory}; of new Lr- (thio) phosphorylthioacetic - hydrazides of thiophosphoric acids with total

X

kp g

ABOUT

I

where R and R - al.kil,

R / and R - alkoxyl, ar.ilo.hil, monsalkyl mio-or dialkyl, n,

X - - oxygen or sulfur.

This} 1-DAY NO can -be a1: c: yulzo-wapa as a posticide.

Method 1 —I-lu | 3- (thio) phosphorylthio-acetyl-g1L, pasid of thiophosphoric acids derived from IS) most of all interactions of gold with thiophosphoric 1-acid. According to the iredlaga.momu method Lr-chloroacetylhydrazide thiophosphoric acids of the general formula 25 РМНННСОСБ.ГС

where r is

R - al-AOX - :; l, ar iloxyl, m (1np ;; lk-1 lam1l- ;; ln dialkylMPUFHgta, is subjected to 1vza ;;:;

RO

where R is alkyl,

 - alkolo: l, ar 1lo :: -; : 1l, monoalkylamine 0-, LP1, kilaminogrui pa, X - oxygen,; whether sulfur, M - alkali metal 1: ll a., Him. The processors amongst: i.; IepTioro o-rga “icheok-rastnopitel, pas trimsr chloroform, g. Of aceto: nl.

The temperature of the reaction is preferably r1-ode. 30 TsebEk reception ;. B - COO L.0 | D Wo. 1. Preparation of L-p- (O-ethyl-.V-butylamidophosphorus: ltioacetyl) -hydrazide 0-butyl-0-feN; lh pyrophore; 1st acid. To a solution of L-3-chloro-iethyl hydrazide 0-butpl-O-phenyltisphosphoric 1kN: lots (0.01 mol) in 50 ml of chloroform and illbavllgot razog. potassium salt 0 ek1l-D-butylamidotlof.osforngnoy ;;;; slots (0.01 g - mol) in 100 ml of hlloroferl; and gfy 40C. Aero. Mass reaction mixture: at 60 ° C for 20 h. The resulting KCl was filtered off, 5 solution was distilled off. The residue is subjected to L- / 3-0-alknl-0-lknll (L-alkylamino) phosphoryl-1-acetyl -1 and idrazides 0-alkyl-0-alkyl (0-aryl) thiophosphoric acids

Chromatographic table - timed content on a fridge with silica gel. The resulting crystals have m., Pl. 86-88 ° C. Yield 74%. Similarly, ay compounds are compounds that feeds IB table. one.

Example 2. Preparation of L-p- (0,0-diethylthiophosphorylthioacetyl) -tidraznda 0-but, nl-0-phenylthiophosphoric acid.

V-p-chloroacetylhydrase, p-o-butyl-0-phenylthiophosphoric acid (0.01 g mol) IB solution, 100 ml aceto, and a solution of o.d. The reaction mass is stirred iBaiOT sch-l 20 ° C 7 hour. The resulting KCl is filtered off, the solvent is distilled off. The product is chromatographed on a cUvinKagels stitch.

Oil is obtained; pf 1.5561; rfi 1,2409.

75% yield.

Analogously. Received soy. Cheneni, with; listed in table. 2

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The structure of the compounds obtained was confirmed by the data of the infrared op. Rascapvi.

Subject invention

1. The method of obtaining Lr (thio) phosphorylthioacet.

 OR

RO

h iiii /

/ PNHNHCOCH2SP (

R

R r

R r

alkyl,

where - alkoxyl, aryloxyl, monoalkylamino- or dpal "illamiworpyinna,

X - oxygen or sulfur,

characterized by the fact that Lr-chloroacetylhydrazides of thiophosphoric. acids react to react with salts of thio- or dithiophosphoric acids in an inert organic solvent, followed by isolation of the target product by known methods.

2. The method according to l. 1, characterized in

that the process is carried out at 20-60 ° C.