SU367112A1 - METHOD OF OBTAINING ETHYROAMIDES ALKYL (Aryl) thiophosphonic acids - Google Patents
METHOD OF OBTAINING ETHYROAMIDES ALKYL (Aryl) thiophosphonic acidsInfo
- Publication number
- SU367112A1 SU367112A1 SU1627258A SU1627258A SU367112A1 SU 367112 A1 SU367112 A1 SU 367112A1 SU 1627258 A SU1627258 A SU 1627258A SU 1627258 A SU1627258 A SU 1627258A SU 367112 A1 SU367112 A1 SU 367112A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- alkyl
- aryl
- ethyroamides
- obtaining
- thiophosphonic acids
- Prior art date
Links
Description
1one
Изобретение относитс к области синтеза фосфорорганических соединений, которые представл ют значительный интерес в качестве пестицидных препаратов.The invention relates to the field of the synthesis of organophosphorus compounds, which are of considerable interest as pesticidal preparations.
Известно, что замена в фосфатах атома кислорода на атом серы приводит к значительному уменьшению токсичности соединени без существенного изменени пестицидных свойств.It is known that the replacement of an oxygen atom by a sulfur atom in phosphates leads to a significant decrease in the toxicity of the compound without a significant change in the pesticidal properties.
Производные алкил- и арилфосфоновых кислот изучены в этом отношении мало.The derivatives of alkyl and arylphosphonic acids are little studied in this respect.
Известен способ получени эфироамидов тиофосфоновых кислот взаимодействием эфирохлоралгмдрпдСВ алк;;лтиофосфо;ю1 ы. кислот с аминами в среде органического растворител .A known method for the preparation of thiophosphonic acid esters of amide by the interaction of ethereal chloroalgmdrpdSV alk ;; lothophospho; y1 s. acids with amines in the environment of an organic solvent.
Эти хлорангидриды не всегда вл ютс доступными соединени ми, так как в услови х очистки перегонкой претерпевают полишнденсацию с отщеплением хлористого алкила.These acid chlorides are not always available compounds, as under conditions of purification by distillation they undergo polysdensation with the elimination of alkyl chloride.
Также известен синтез амидов диалкилфосфорных кислот по реакции Аттертона и Тодда , основанной на взаимодействии дпалкилфосфитов с в среде четыреххлористого углерода.Also known is the synthesis of dialkyl phosphoric acid amides by the reaction of Atterton and Todd, based on the interaction of dipalkyl phosphites with in carbon tetrachloride.
С целью упрощени способа и расщирени ассорти.мента конечных продуктов предлагаетс метод синтеза эфироамидов алкил (арил) тиофосфоновых кислот взаимодействием легкодоступных кислых алкиловых эфиров алкил In order to simplify the process and expand the assortment of the final products, a method for the synthesis of alkyl (aryl) thiophosphonic acid esters of amide by the interaction of readily available acid alkyl esters of alkyl is proposed.
(арил)тиофосфонистых кислот с аминами в среде органического растворител , например четыреххлористого углерода. Реакци проходит по схеме(aryl) thiophosphonous acids with amines in an environment of an organic solvent, for example carbon tetrachloride. The reaction proceeds according to the scheme
RP (S)(OR) Н + 2R2NH -f (S)(OR) NR2 -I- RoNH-HCl-f CHCU где R - алкил или арил; Rи R - алкил.RP (S) (OR) H + 2R2NH -f (S) (OR) NR2-I-RoNH-HCl-f CHCU where R is alkyl or aryl; R and R are alkyl.
Пример 1. Изопропиламид н-пропилового эфира этилтиофосфоновой кислоты.Example 1. Isopropylamide n-propyl ester of ethylthiophosphonic acid.
К -ргсгзору 8 г (0,0526 г-.го.-/) х ;слогоK-rigsgzor 8 g (0.0526 g-.go .- /) x;
и-upon и левого эфира ЭТНЛТ1:Оф;ч1:}ЗНИСТОНand-upon and the left ether ETNLT1: Of; ch1:} ZNISTON
кислоты в 50 М.1 четыреххлорпстого углерода при охлаждении льдом и псрем иглвании прибавл ют 7 г (0,119 г-.мо.гь изог.ропилампна в течение 30 мин. На другой .тень осадок .хлоргндрата изопропилам1П1а он Acids in 50 M.1 of carbon tetrachloride add 7 g (0.119 g —mo.i. of isogropyllampnum within 30 minutes) under ice-cooling and needle-feeding over 30 minutes. On the other. Shade of chlorophosphate isopropyl
льтровыоают . Из фильтрата после уиариБ, ;1 и иереrojiKH в вакууме получают 8,6 г (72.8%) изо О/.ltro 8.6 g (72.8%) of iso O / are obtained from the filtrate after baterium,; 1 and hierojiKH in vacuum.
Эфира этилтпопропиламида п-пропилового фосфоновой кислоты. ст.; 1,4808,Ethyl ethyl propyl amide of p-propyl phosphonic acid. v .; 1.4808,
Т. кип. 79--80Т/1 мм рт. elf 0,9980. T. Kip. 79--80T / 1 mmHg elf 0.9980.
С 46,20; Н 9,50; Р 15,07; N6,64. Найдено, % CsHaoNOPSFrom 46.20; H 9.50; P 15.07; N6.64. Found,% CsHaoNOPS
С 45,91; Н 9,63; Р 14,80,C 45.91; H 9.63; R 14.80,
Вычислено. N 6,69.Calculated. N 6.69.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1627258A SU367112A1 (en) | 1971-03-01 | 1971-03-01 | METHOD OF OBTAINING ETHYROAMIDES ALKYL (Aryl) thiophosphonic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1627258A SU367112A1 (en) | 1971-03-01 | 1971-03-01 | METHOD OF OBTAINING ETHYROAMIDES ALKYL (Aryl) thiophosphonic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU367112A1 true SU367112A1 (en) | 1973-01-23 |
Family
ID=20467235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1627258A SU367112A1 (en) | 1971-03-01 | 1971-03-01 | METHOD OF OBTAINING ETHYROAMIDES ALKYL (Aryl) thiophosphonic acids |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU367112A1 (en) |
-
1971
- 1971-03-01 SU SU1627258A patent/SU367112A1/en active
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