SU350786A1 - METHOD FOR OBTAINING ALYMATIDE ALIPHATIC - Google Patents

Description

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A method is proposed for the preparation of arnlaminides of aliphatic acids and acids of the benzene range, which can be widely used in organic synthesis.

A known method for producing amiphatic | Cescic acids and acids of the benzene range is that the aliphatic acid or the acid of the benzene range is reacted with the amine at the boiling point of the reaction mass in the presence of a catalyst — phosphoric or phosphinic acid or their derivatives — in a mixture solvents consisting of trichlorobenzene and toluene or xylene, followed by separation of the target product by a known technique. However, the process is carried out in an environment of hard-to-reach, scarce and toxic solvents in a mixture of trichlorobenzene with toluene or xylene - in the presence of hard-to-reach catalysts, phosphorous or phosphinic acid or their derivatives, which requires the use of special equipment and complicates the technology.

In order to simplify the technological process, it is proposed to use the halides of metals of the first, second and third groups of the periodic system or the halides of metals of variable valence as a catalyst.

EXAMPLE 1 To a round bottom flask equipped with a reflux condenser, 0.1 mol of aniline, 0.1 mol of acetic acid and 0.05 l of sodium chloride are charged. The reaction mixture is heated to boiling and is continued to boil for 3 hours. Then the reaction mass is poured into water, which is acidified with hydrochloric acid, while being transferred. The precipitated precipitate is filtered off, washed with 5% soda solution and solid. Yield 10.0 g (83.3%).

Example 2. In the same way as Example 1, 0.1 mol of anplina, 0.1 mol of propionic acid and 0.025 mol of lithium bromide, you.code 9.25g (62%), are loaded.

Example 3. Analogously to Example 1, 0.1 mol of aniline, 0.1 mol of benzoic acid and 0.06 mol of sodium chloride are loaded. Yield 15.0 g (76.1%).

Example 4. Analogously to Example 1, 0.1 mol of aniline, 0.1 mol of stearic acid and 0.05 mol of potassium chloride are charged. Yield 35 g (98.3%).

Example 5. Analogously to Example 1, 0.05 mol of aniline, 0.05 mol of phenylacetic acid and 0.025 mol of sodium bromide are loaded. Yield 8.6 g (81.9%).

hydrochloric acid and 0.025 mol of sodium bromide.

Exit 7 ,, - Ei, 9 ° / o) .-- --P p ji.M.ep,, 7. Analogously to Example 1, O, 02.5 mol of p-brbmoy18nzoic acid, 0.2 Jn.anidyc., And -0.05 vtio / ib of potassium bromide is loaded. The yield is 5.25-g; R

An example and. Analogously to Example 1, 0.05 mol of o-toluidipa, 0.05 mol of acetic acid, “0.025 mol of sodium bromide, is charged. Yield 7.5 g (90.9%).

Example 9. Analogously to Example 1, 0.05 mol of undecylenic acid, 0.05 mol of aniline and 0.0125 mol of CaClj-21 20 are charged. Yield 8.5 2 (68.0%).

Example 10. Analogously to Example 1, 0.05 mol of cinnamic acid, 0.1 mol of aniline and 0.0125 mol of BaBr2-6H2O are loaded. Yield 10.23 (91.6%).

Example 11. Analogously, a mol 1 is charged with 0.1 mol of aniline, 0.1 mol of acetic acid and 0.0125 mol of potassium iodide. Output 11.0. g (91.7%).

Subject invention

The method of producing aryl amides of aliphatic acids and benzene acid acids by reacting aliphatic acid or

acid benzene with amine in the presence of a catalyst at the boiling point of the reaction mass, followed by separation of the target product by a known technique, characterized in that, in order to simplify

of the technological process, the halides of the metals of the first, second and third groups of the periodic system or the halides of metals of variable valence are used as a catalyst.