SU1741804A1 - Method for production of dry effervescent beverages - Google Patents

Abstract

Uses: food and medical industry. SUMMARY OF THE INVENTION: The acid fraction of the components is mixed with a 7-10% ethanol solution of shellac. The alkaline fraction of the components is mixed with a p 10-20% solution of polyvinylpyrrolidone in liquid extracts of ginseng, zamanihi, rhodinols, eleutherococcus, aralia, levzey, schisandra, or pantocrin. After granulation and drying, both fractions are combined and tableted. 3 tab.

Description

This invention relates to the medical industry and can be used to produce dry effervescent drinks that have tonic, prophylactic and healing properties.

The modern medical industry has widely produced dry granular or tableted effervescent beverages. Their technology is very diverse.

To obtain granular effervescent granules, a separate granulation of the carbonate fraction is used, which is moistened with a 1-25% aqueous surfactant solution, dried at a temperature of up to 93 ° C, followed by mixing with the anhydrous acid fraction.

There is also known a method according to which the carbonate alkaline fraction is granulated after being wetted with an aqueous solution of maltodextrin and also mixed with the dried acid fraction.

The disadvantage of these methods is the use of aqueous solutions of surfactants and

IUDs that do not allow the drying temperature to be reduced (even under vacuum) to less than 40 ° C, which can negatively affect the stability of many groups of medicinal substances. In addition, the acid fraction is not stabilized here, which reduces the stability of the granules or tablets themselves.

There is also known a method according to which the moistening of the acid and carbonate fraction is produced jointly with a solution of paraffin with the addition of surfactant (emulsifier 1) in an organic solvent. Although this simplifies the manufacturing process and increases the stability of effervescent tablets, but making drinks from them is impossible due to the insolubility of paraffin in water, these tablets can be used for internal use or as contraceptives.

Close to the invention is a method for producing effervescent dosage forms containing a mixture of 7-57.5% granulated drugs (alkaloids, antibiotics, vitamins, expectorant, antihistaminic, laxatives, antipyretic, 6os

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anti-inflammatory and anti-inflammatory drugs with effervescent ingredients. The stability of the granules produced by this method is achieved by moistening the mixture of the acidic and alkaline fractions of the drink with the help of surfactants, with aqueous solutions of which the powder is moistened and dried in a vacuum, and then packed in sealed packages,

The basis of this method of producing effervescent beverages is the use of aqueous solutions of surfactants as stabilizing the acidic and alkaline components of the effervescent mixture. Moisture removal in such cases occurs at temperatures above 40-60 ° C and in high vacuum, which adversely affects the stability of vitamins at temperatures above 40 ° C, they begin to oxidize, as well as alkaloids, glycosides, antibiotics, which are actively destroyed at high drying temperatures.

The negative feature of wetting a mixture of acidic and alkaline components is the interaction between the constituents at the time of wetting, which leads to a decrease in the gas-forming ability of the granules.

The literature does not describe the production technology of dry effervescent granules and tablets with dry or liquid extracts, tonic effect (eleutherococcus, ginseng, zamaniha, rhodiola rosea, schizandra Chinese, levze, pantocrin, arali).

The purpose of the invention is to develop a method for the production of dry effervescent beverages (in granules and tablets) containing these extracts for prophylactic or therapeutic use in medicine.

A method for producing dry effervescent granules or tablets is as follows.

The components of the recipe, depending on the physicochemical properties, are divided into acid-containing and co-containing fractions that are moistened — the first 7–10% ethanol solution of the natural polymer — shellac, and the second fraction by a 10–20% solution of low-molecular polyvinylpyrrolidone (PVP), the wetted mass is granulated to a particle size of 1.5 mm and exists to a residual moisture content of not more than 1.5%, after which the dry granules are mixed in a predetermined proportion (the pH of the drink should be in the range of 5.3 ± 0, 3) and packaged in hermetically sealed pack forging provided with a stopper vlagopopyuschayuschim agent.

Tablets are compressed with an average weight of 4.8 ± 0.2 g, which is enough to produce 200.0 ml of effervescent powder and these are packaged in hermetically sealed canisters.

The composition of effervescent beverages are introduced

both dry and liquid plant extracts of tonic action in prophylactic doses (ginseng, zamanihi, eleutherococcus, aralia, rhodiola, levzey,

0 lemongrass, panktokrin) and 0.050-0,500 ascorbic acid. As a moisture protective (stabilizing and binding substances), a 7-10% ethanol solution of natural shellac polymer is used.

5 and 10-20% solution of synthetic low molecular weight polyvinylpyrrolidone (PVP),

The indicated limits of the concentrations of shellac and PVP set experimentally, since a high content of polymers increases the stability of the granules and tablets, but impairs their solubility, and vice versa. In this case, it is assumed that the period of stable storage of effervescent forms with

5 normal conditions should be within 1.5-3 g., Solubility - 1.5 min.

When preparing the acid fraction for granulation, it was experimentally established that the amount of moisturizing fluid

0 (alcoholic solution of shellac), which provides the optimal technological properties of the granulated mass, should be in the range of 35.0-45% of the mass of dry dry matter in the acid fraction. Otherwise, the mass either does not stick together (crumbles), or turns into a slurry, which complicates the process of granulation. Since the amount of moisturizing fluid cannot regulate the content of shellac in the mass (we

0 was injected in the amount of 40% by weight of dry matter), to study the effect of shellac content on tablet stability during storage and the effect on the time of their dissolution in water, the concentration of shellac of the active liquid (alcohol) is within 3-12%. In this way, an alkaline fraction is obtained by changing the content of PVP in the liquid extracts and tinctures used for moistening, but the dose of liquid

0 extracts are adjusted by diluting the initial concentration of these preparations with ethanol. For example, the therapeutic dose of Eleutherococcus extract is 40 drops (1 ml per dose), to moisten the alkaline fraction that consumes 3.5 g of a single dose, 40% of the liquid or 1.4 ml of the extract is needed, therefore 0.4 ml are missing. supplemented with 40% alcohol, in which the calculated amounts of the obtained extract solutions are prepared for the extract or

PVP was dissolved in tinctures, and its concentrations in a moisturizing liquid were examined in a range of 3-20%. Data on the study of the effect of polymer content on the stability and solubility of effervescent tablets are presented in Table. 1-3,

At the same stage of the technology, when wetting dry components, moisture appears (as extracts are prepared on ethanol solutions from 30-900) / which must be disposed of, for which wet granules are dried to a residual moisture of 1.0 ± 0, five%.

Analyze the data table. 1, it can be concluded that the use of a shellac alcohol solution at a concentration of more than 10% adversely affects the solubility of effervescent tablets, although their stability over time increases dramatically (up to 5 years). Similar results were obtained with tablets containing other liquid extracts (see tab. 2 and 3).

PRI me R 1. Production of dry fizzy drink with liquid extract of eleutherococcus.

The composition of the formulation in one dose for the preparation of 200.0 ml of drink, ml: Eleutherococcus extract liquid 0.5

Ascorbic acid 0,050

Citric Acid1,050

Sodium bicarbonate0,950

Carbon saccharin 0,010

Sugar powder 2,000

Lemon essential oil 0,500

Shellac0.005

Polyvinylpyrrolidone (PVP) 0.010 All components are divided into two fractions: acidic (ascorbic acid, citric acid) and alkaline (extract of eleutherococcus, sodium bicarbonate, saccharin, powdered sugar, lemon essence).

The acidic fraction is moistened with a 7% ethanol solution of shellac and rubbed through a granulator with a hole diameter of 1.5 mm, and then dried to a residual moisture content of not more than 1.0 ± 0.5% at a temperature not higher than 40 ° C. . The alkaline fraction is moistened with 10% PVP solution, which is dissolved in the liquid extract of Eleutherococcus with the addition of lemon essence, then granulated to 1.5 mm particles and dried at a temperature not exceeding 40 ° C to a residual moisture content not exceeding 1, 0 ± 0.5%. Dry granules are mixed and packaged in hermetically sealed vials with corks fitted with desiccant agents. If necessary, tablets with an average weight of 4.8 ± 0.20 g, which are hermetically packaged in canisters, are obtained from the granules. To prepare 200.0 ml of effervescent beverage, 4.8 ± 0.30t granules or one tablet is required. In this case, a straw-colored, sweet-sour taste drink (pH - 5.2 ± 0.2) with the smell of lemon is formed. The expiration date of hermetically sealed granules is 1.5 g, tablets - 3.0 g.

PRI mme R 2. Method for the production of dry fizzy drink with Rhodiola rosea. The composition of the recipe for the preparation of 200.0 ml of effervescent beverage:

Rhodiola extract, ml 0,1

Ascorbic acid, r0,10

Citric acid, r2,00

Sodium bicarbonate, g2,00

Sugar powder, 3,00

Saccharin carbonate, g0,020

PVP0,005

Shellac0.005

All components are divided into two fractions: the acid fraction (ascorbic acid, citric acid) is mixed and moistened with a 3% ethanol solution of shellac, then granulated to 1.5 mm particles and dried at a temperature not higher than 40 ° C to a residual moisture content no more than 1.5%. The alkaline fraction (sodium bicarbonate, powdered sugar, saccharin carbonate, liquid rhodiola extract) is moistened with 15% PVP solution, which is dissolved in the liquid rhodiola extract and the wet mass is granulated to particles no larger than 1.5 mm, after which cyiuaf at temperature not higher than 40 ° C to a residual moisture content not exceeding 1.5%. If necessary, tablets with an average weight of 3.6 ± 0.20 g are made of dry granules and sealed. The granules are immediately packaged in vials with corks fitted with a moisture-absorbing agent. To prepare 200.0 ml of the drink, it is necessary to dissolve 7.2 ± 0.20 g of granules or two tablets. Cream-colored drink with the smell of rhodiola with sweet and sour, tart taste (pH 5.5 ± 0.2). The shelf life of the granules is 1.5 g, 3.0 g tablets, in hermetically sealed packaging.

Example Method for the production of dry fizzy drink with liquid ginseng extract.

The composition of the recipe for the preparation of 200.0 ml of drink:

Ginseng extract liquid, ml 0.2

Ascorbic acid 0,10

Lemon acid1.05

Sodium bicarbonate

Sugar powder

Saccharin carbonate

Odorant

Shellac

PVP

Dye acid red 0,001

The components are divided into two fractions: acid (ascorbic acid, citric acid) and alkaline (sodium bicarbonate, ginseng extract, powdered sugar, saccharin carbonate, perfume). The acidic fraction is moistened with an 8% ethanol solution of shellac and granulated to a particle size of 1.5 mm. The alkaline fraction is moistened with a 15% solution of PVP and granulated to particles of 1.5 mm in diameter and dried to a residual moisture content of not more than 1.3 ± 0.2%. The granulate fractions are mixed; if necessary, tablets with an average weight of 4.3 ± 0.2 g are made. Dry granules and tablets are packed in hermetically sealed vials with corks fitted with desiccant agents. The expiration date of the granules is 1.5 g of tablets and 3.0 g. In a packaged form. To prepare 200.0 ml of an effervescent drink, it is necessary to dissolve 4.3 ± 0.2 g of granules or one tablet 2, 00 kg Ready-to-drink pink color with a wate introduced sweet and sour fragrance

0.05 taste.

Claims (1)

0.005 5 Formula of Invention 0.005 Method of production of dry effervescent beverages, including mixing tonic additives, components of the acid and alkaline fractions with a binder solution, granulating the mixture, drying and tabletting, characterized in that, in order to improve the quality of the finished product, mixing the components of acid and alkali fractions with binder solution 15 are carried out separately, 7-10% ethanol solution of shellac is used as a binder for the acid fraction of the components, polyvinylpyrrolidone is used for the alkaline fraction, 20 supplements take liquid extracts of ginseng, zamanihi, rhodiola, eleutherococcus, aralia, left, lemongrass, or pantocrin, and polyvinylpyrrolidone is pre-mixed with liquid extract to 25 to obtain its 10-20% solution, and the granules of alkaline and acid fractions after drying are combined are Table 1 p 10 Table 2 n 10 Table 3 n 10