SU1709909A3 - Method for synthesis of (2-thienylmethyl)-thiourea derivatives - Google Patents

Abstract

The invention relates to heterocyclic compounds, in particular to the preparation of derivatives

Description

This invention relates to a process for the preparation of (2-thienylmethyl) thiourea derivatives, which can be used as feed additives for various animals.

The aim of the invention is a method for producing new thiourea derivatives, which would be more effective additives to animal feed than structural analogues. For example, furfurylthiourea, a well-known drug zinc bacitracin.

Example 1. P-5Zen-5- (2-thienylmethyl) -thiourea.

To the emulsion of 73.56 g (0.65 mol) of tenylamine and 500 ml of gasoline, 97.0 (0.65 mol) of benzyl isothiocyanate are added dropwise with stirring. The reaction mixture is stirred at

Room temperature for an hour, then filtered and washed with gasoline. 153.75 g of the expected compound are obtained. Yield 89.6%, mp. 108-109С (from methanol).

9 .

PRI mme R 2. Y-Cyclohex, IL-S - (2-thienylmethyl) -thiourea.

82.6 g (0.7 mol) of tenylamine and 98.86 g (0.7 mol) of cyclohexyl isothiocyanate are reacted by analogy with example 1. 171.6 g of target compound are obtained. Exit 96.4, m.p. 112-ПЗ ° С (from methanol).

Froze N- (1-Naphthyl) -N- (2-thienylmethyl) -thiourea.

Claims (2)

2.2b g (0.02 mol) of tenylamine and 3.7 g (0.02 mol) of 1-per () thylisothiocyanate are reacted as follows. 5.8 analogies are obtained with Example 1 of the title compound, yield 38 mp. (from ethanol). The compounds of general formula I cause an increase in the weight of animals, especially pigs, sheep, chickens, which is associated with improved digestibility of feed. The effect of the proposed compounds was studied in test experiments. , Experience on the slopes. This experiment was carried out on hot rods with a fattening time of 0 days. The animals received feed of the following composition, wt .: Grinded corn70.0 Flour from alfalfa Class II 24.0 Urea 3.0 Feed lime 0.50 Monocalcium phosphate 1, 0 Crystalline sodium sulfate, .0.5 Feed salt 0.5 (feed for bed) Lampmpreix XIX (phylaxi) 0.5 Test compounds were added in the form of standard granules at a concentration of 50 ppm. Animals of the control group received feed of the above composition, but without the active substance. . For the experience, only Hungarian merino were taken. Each group consisted of 12 rats, for each treatment 3 groups of animals were used. During the O-day experiment, each head was weighed five times, namely at the beginning of the experiment and every 10 days (the last time on the 40th day), always at the same time. Indicated weight without rounding. The amount of food eaten was determined in each decade and for each group. 9 The results are shown in Table. 1 and the increase in weight and the amount of food eaten is indicated as an average of three experiments. As can be seen from the above results, the compounds of general formula I significantly improve the digestibility of the feed, i.e. weight gain per 1 kg can be achieved with less feed. The compounds of general formula I do not have an antibiocidal effect, therefore, their use does not show the disadvantages of antibiotics. In addition, a significant advantage of the compounds of the general formula I is that they do not have a mutagenic effect. Experience with chick tami. The experiment was carried out with broiler chickens. The results are shown in Table. 2. In the group of chickens at the age of 9 days, 2.3% of feed can be saved, based on the control group (calculated for 1 kg of live weight). Claims for the preparation of (2-thienylmethyl) -thiourea derivatives of the formula O -% - NH-C-KH-A 8 II) where A is phenyl-C-C-alkyl, C-Cd-cycloalkyl or naphthyl, characterized in that phorA-NCS isothiocyanate has the indicated values. interact with tenylamine formula iL CHj-NH Table 1 Average daily weight gain, g Also, Specific feed consumption, kg / kg Also, 266.7 105.2 3.79 95.9 table 2