SU1698676A1 - Method for evaluating thyroid gland activity - Google Patents

Abstract

This invention relates to medicine, in particular to methods for determining the functional state of the thyroid gland. The purpose of the invention is to improve the accuracy of determining the activity of the thyroid gland. To do this, when determining the activity of the thyroid gland, its morphometric parameters are found at a height. cellular structures of thyroid follicles and morphofunctional indices according to the degree of vacuolization of colloid in thyroid follicles and according to the ratio of morphometric and morphofunctional indices, in arbitrary units determine the level of activity, diagnosis, respectively, in the range of 0-50; 50.1-1.0.0; 100.1-200 units of the hypo-, EU- and hyperthyroid state of the thyroid gland. s (/)

Description

This invention relates to medicine, in particular to methods for determining the functional state of the thyroid gland.

The aim of the invention is to improve the accuracy of determination.

The method is implemented as follows.

From the thyroid gland, taken from an experimental animal or on a clinical biopsy, histological preparations are prepared according to a known technique and subjected to microscopic examination, during which the height of the follicular epithelium is measured and the percentage of follicles with cubic and cylindrical epithelium is measured. and also, the percentage of follicles with total, peripheral and single vacuolization of the colloid.

The activity of the gland is judged by the ratio of morphometric and morphofunctional parameters by the formula

BUT

TO(

TO

+ K + K (conditional

units)

where K 4 and K / 2 - the percentage of follicles with cubic and cylindrical epithelium; K and KO. - percentage

follicles with peripheral and total vacuolization, respectively. Ball (in conditional units) for hypo-, eu- and hyperthio

Ј 00 O & one

ABOUT

the rheoid state of the gland lies respectively in the range of 0-50; 50.1-100 and 100.1-200 conventional units (UE). PRI me R 1. Sick M. 29 years suffering from thyrotoxicosis during

3 years. The main exchange + 25.5%. Sco m

absorption rate I by the thyroid gland after 2 h 15%, after 4 h 40%, 2k h 38%. Biopsy material obtained by resection of the thyroid gland. % follicles with flat epithelium3, 4% follicles cubic epithelium 50.5% of follicles cylindrical epithelium46.1% of follicles

without vacuole 6,6

% of follicles with peripheral

vacuolization of 74.4% of follicles with total vacuolization19, 0

A, 5 UE (hyperthyroid state).

PRI mme R 2. Patient B., 44, had no thyroid disease. Death came from an accident. The material obtained at the autopsy.

% follicles

flat epithelium

% follicles

with cubic

epithelium

% follicles

with cylindrical

epithelium

% follicles

without vacuoles

% follicles

with peripheral

ten

15

20

25

thirty

35

vacuolization of 14.3% of follicles with total vacuolization 7, 1 A 67.2 (euthyroid state) Example 3- Experimental animal (rat no. 24) after a total vibration of 50 Hz, amplitude 0.3 them, time one session 90 min, with 90-fold exposure. % follicles with flat epithelium 29.6% of follicles with cubic

epithelium 69,6

% follicles with cylindrical epithelium0,8

% follicles without vacuole sites 91, 9

% of follicles with peripheral vacuolization 8.1% of follicles with total vacuolization

A 39.65 UE (hypothyroid state).

Claims (1)

Invention Formula The method for determining the activity of the thyroid gland, including the finding of its morpholitic indices according to the height of the cellular structures of thyroid follicles, a tl and h a) o40 45 Editor M. Bokereva y and, with the aim of increasing the accuracy of determination, the morphofunctional thyroid parameters are determined by the degree of vacuolization of the colloid in the thyroid follicles, and by the ratio of morphometric and morphofunctional indicators, in arbitrary units the level of activity is determined, respectively at 0–50; 50.1-100; .100.1-200 conditional units of the hypo-, memory, and hyperthyroid state of the thyroid gland. Compiled by A. Dreval Tehred M.MorgentalKorrektor N. Revska 6.8 80.5 12.7 78.6 50 0 five 0 five 0 five vacuolization of 14.3% of follicles with total vacuolization 7, 1 A 67.2 (euthyroid state) Example 3- Experimental animal (rat no. 24) after a total vibration of 50 Hz, amplitude 0.3 them, time one session 90 min, with 90-fold exposure. % follicles with flat epithelium 29.6% of follicles with cubic epithelium 69,6 % follicles with cylindrical epithelium0,8 % follicles without vacuole sites 91, 9 % of follicles with peripheral vacuolization 8.1% of follicles with total vacuolization A 39.65 UE (hypothyroid state). Invention Formula The method for determining the activity of the thyroid gland, including finding its morpholitic indices by the height of the cellular structures of thyroid follicles, is of a kind with the fact that, with the aim of increasing the accuracy of determination, the morphofunctional indicators of the thyroid gland are additionally determined the degree of vacuolization of the colloid in the thyroid follicles, and the ratio of morphometric and morphofunctional indices, in arbitrary units, determine the level of activity, the diagnosis, respectively, at 0-50; 50.1-100; .100.1-200 conditional units of the hypo-, memory, and hyperthyroid state of the thyroid gland.