SU1695929A1 - Method of myocardial infarction treatment - Google Patents

Abstract

The invention relates to cardiology and can be applied in pharmacology, carried out in the acute period of myocardial infarction. The goal is to increase efficiency by limiting the area of necrosis. The method is implemented by administering drugs that stabilize hemolymphodynamic indices, in particular, 0.5 ml / kg of obeidan, 5 ml / kg of reogluman and 150 U / kg of heparin, which possess lymphogonic and anti-clotting properties, are administered intravenously.

Description

The invention relates to cardiology, in particular to pharmacotherapy, and can be used in the treatment of acute myocardial infarction.

The aim of the invention is to increase efficiency by limiting the zone of necrosis.

The method is carried out as follows.

The animal was intravenously administered injections of 0.5 mg / kg, reogluman 5 mg / kg and heparin 150 U / kg. possessing lymphogonic and anti-clotting action.

Example Dog Ball weighing 12 kg under non-buttered anesthesia (360 mg intravenously) Drain the thoracic lymphatic duct (HLP) Blood pressure (BP) in the femoral artery and electrocardiogram (ECG) are recorded. per minute pulse 110 per minute, BP 160/100 mm Hg, CFC 187 µmol / l, PDG 165 µmol / l. Conduct thoracotomy. Next, a ligature is brought under the anterior interventricular branch of the left coronary artery and ligated (model of acute myocardial infarction). 1.5 h after ligation, a slowing of the speed of lymphatic drainage (4 drops per minute), hemodynamic disturbances (BP 80/40 mm Hg, pulse 115), marked coronary changes were observed on the ECG. An increase in the coagulability of both blood and lymph was noted with an increase in the content of enzymes (CK 748 µmol / L LDH 610 µmol / L). After 1 to 5 hours after ligation, obeidan 0 5 mg / kg was administered intravenously, immediately after that reogluman 5 ml / kg and heparin 150 U / kg After 1 min HELL 120/80 mm Hg, pulse 105 min ECG, increase in lymphatic drainage (60 drops per minute) After 45 min. BP 120/8 mm Hg pulse 105 per minute. sinus rhythm positive staso

with

(Oh (L

yu che

Bilny improvement of an ECG. Lymph flow 56 drops per minute. A decrease in blood and lymph coagulability was noted, a sharp increase in the activity of enzymes (CPK and LDH) was prevented. A morphological study showed that the dog had significantly smaller areas of necrosis, a less pronounced inflammatory response, significantly less lymphostasis and impaired microcirculation,

| Thus, it can be seen that the administration of the complex increases the lymphatic drainage from the thoracic duct, lowers the coagulability of blood and lymph, which leads to a decrease in the necrosis zone in the myocardium, an indicator of which is normalization of the ECG, decrease in the level of the enzyme ETU and LDH in the blood, and improvement of myocardium. The proposed method of treatment is harmless and does not deny the use of other methods of treating this disease, at the same time it can supplement them, affecting that link (lymphatic system), the pathogenetic significance of which in acute myocardial infarction is undeniable, since it eliminates lymphostasis, interstitial edema followed by improvement of myocardial blood supply in the ligated artery pool.

Claims (1)

Invention Formula A method of treating myocardial infarction by administering medicinal substances to an experimental animal, characterized in that, in order to increase efficiency by limiting the necrosis zone, as a medicinal substance, 0.5 mg / kg reogluman is sequentially administered intravenously at a dose of 0.5 mg / kg kg and heparin 150 U / kg.