SU1681331A1 - Method for modeling circulation of malaria infection agent - Google Patents
Method for modeling circulation of malaria infection agent Download PDFInfo
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- SU1681331A1 SU1681331A1 SU894730976A SU4730976A SU1681331A1 SU 1681331 A1 SU1681331 A1 SU 1681331A1 SU 894730976 A SU894730976 A SU 894730976A SU 4730976 A SU4730976 A SU 4730976A SU 1681331 A1 SU1681331 A1 SU 1681331A1
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- USSR - Soviet Union
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- malaria
- mosquitoes
- pathogen
- circulation
- malaria infection
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение относитс к медицине и может быть применено в области экспериментального моделирований мал рии. Цель изобретени - приближение к реальному процессу циркул ции возбудите/ мал рии человека, Это достигаетс тем, что в качестве переносчика используетс комар Anopheles sacharovi или Anopheles pulcherrimus - реальные переносчики возбудители мал рии между людьми Средн зараженность увеличиваете в 1,5 разаThe invention relates to medicine and can be applied in the field of experimental modeling of malaria. The purpose of the invention is an approximation to the actual circulation process of excitement / malaria of a person. This is achieved by using the mosquito Anopheles sacharovi or Anopheles pulcherrimus - the real carriers of malaria among people. The average infection rate increases by 1.5 times.
Description
Изобретение относитс к медицине и может быть применено в области экспериментального моделировани мал рии дл изучени эпидемического процесса, испытани лекарственных и профилактических препаратов, средств борьбы с переносчиком и г.п.The invention relates to medicine and can be applied in the field of experimental modeling of malaria for studying the epidemic process, testing medicinal and prophylactic drugs, vector control agents, and the like.
Целью изобретени вл етс приближение к реальному процессу циркул ции мал рии человека.The aim of the invention is to approach the actual circulation of human malaria.
Способ осуществл ют следующим образом .The method is carried out as follows.
Цыпленка заражают возбудител ми мал рии черзз комаров An.sacharovi или An.pulcherrimus, которые вл ютс активными переносчиками мал рии человека в действующих очагах этого заболевани .The chick is infected with pathogens of malaria by the mosquitoes An.sacharovi or An.pulcherrimus, which are active carriers of human malaria in the active foci of this disease.
П р и м е р 1. Вз т цыпленок, зараженный возбудителем мал рии P.galllnaceum, на нем накормлено 40 самок An.sacharovi, после насыщени кровью комары помещены в термостат-с температурой 28 t 1°C. Через 10 сут. комары извлечены из термостата и просмотрены. Среди них обнаружено 8 погибших особей (выживаемость 80%) Из оставшихс э живых 12 самок исследовано на наличие возбудител , который обнаружен у8 особей (заражаемость 67%). Остальным комарам дана возможность пить кровь 9 незаражекных цыпл т Через 9 дней после этого у 8 цыпл т обнаружены клинические признаки мал рии. Анализ крови больных цыпл т показал, что у кахдого из них в крови содержатс возбудители мал рии . На этих цыпл тах вновь накормлены здоровые комары, у которых впоследствии обнаружены типичные формы возбудител . К насто щему времени осуществлено 6 циклов передачи возбудител с помощью комаров An.sacharovi.PRI me R 1. A chicken infected with the pathogen of Malaria P..galllnaceum was taken on it, 40 An.sacharovi females fed on it, after being saturated with blood, the mosquitoes were placed in a thermostat with a temperature of 28 t 1 ° C. After 10 days. mosquitoes are removed from the thermostat and viewed. Among them, 8 dead individuals were found (survival rate of 80%). Of the remaining 12 live females, we examined the presence of the pathogen, which was found in 8 individuals (67%). The rest of the mosquitoes were given the opportunity to drink the blood of 9 non-contagious chickens. 9 days after that, 8 chickens showed clinical signs of malaria. An analysis of the blood of sick chickens showed that in each of them pathogens of malaria are contained in the blood. On these chickens, healthy mosquitoes were again fed, in which typical forms of the pathogen were subsequently found. To date, 6 pathogen transmission cycles have been performed with the help of An.sacharovi mosquitoes.
Таким образом, установлена работоспособность предлагаемой модели: комары воспринимают возбудител и передают его хоз ину: что подтверждено клинически, паразитологически и путем ксенодиагности- ки.Thus, the efficiency of the proposed model was established: mosquitoes perceive the pathogen and pass it on to the host: as clinically, parasitologically, and confirmed by xenodiagnosis.
П р и м е р 2. Вз т цыпленок, зараженный возбудителем мал рии P.gallinaceum,PRI mme R 2. A chicken infected with the pathogen of malaria P..gallinaceum,
W WW W
на нем накормлено 36 самок An.pulcherrlmus, после насыщени кровью комары помещены в термостат с температурой 28 ± 1°С. Через 10 сут комары извлечены из термостата и просмотрены. Среди них обнаружено 10 погибших особей (выживаемость 72%). Из оставшихс в живых 16 самок исследовано на наличие возбудител , который обнаружен у 12 особей (заражаемость 75%). Остальным комарам дана возможность пить кровь 5 незараженных цыпл т. Через 9 дней после этого у А цыпл т обнаружены клинические признаки мал рии . Анализ крови больных цыпл т показал, что у каждого из них в крови содержатс возбудители мал рии. На этих цыпл тах вновь накормлены здоровые комары, у которых впоследствии обнаружены типичные формы возбудител . К насто щему времени осуществлено семь циклов возбудител с помощью комаров An.pulcherrlmus.36 An.pulcherrlmus females are fed on it, after being saturated with blood, the mosquitoes are placed in a thermostat with a temperature of 28 ± 1 ° C. After 10 days, mosquitoes are removed from the thermostat and viewed. Among them, 10 dead individuals were found (survival rate of 72%). Of the 16 surviving females, the presence of the pathogen, which is found in 12 individuals (75% infectious), was examined. The rest of the mosquitoes were given the opportunity to drink the blood of 5 uninfected chickens. 9 days after that, the chickens showed clinical signs of malaria in A. A blood test of sick chickens showed that each of them contains malaria pathogens in their blood. On these chickens, healthy mosquitoes were again fed, in which typical forms of the pathogen were subsequently found. To date, seven pathogen cycles have been performed with the help of An.pulcherrlmus mosquitoes.
Таким образом, установлена работоспособность предлагаемой модели: комары воспринимают возбудител и передают его хоз ину, что подтверждено клинически, па- разитологически и путем ксенодиагностики.Thus, the efficiency of the proposed model was established: mosquitoes perceive the pathogen and pass it on to the host, which is confirmed clinically, parasitologically and by xenodiagnosis.
Заражаемость переносчиков в разных модел х не идентична: в предлагаемой модели средн дол зараженных особей почти в полтора раза выше, чем в известной (78% против 56%), а обилие возбудител выше в 5 раз (96 против 19).Infectious carriers in different models are not identical: in the proposed model, the average percentage of infected individuals is almost one and a half times higher than in the known (78% versus 56%), and the abundance of the pathogen is 5 times higher (96 versus 19).
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU894730976A SU1681331A1 (en) | 1989-06-30 | 1989-06-30 | Method for modeling circulation of malaria infection agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU894730976A SU1681331A1 (en) | 1989-06-30 | 1989-06-30 | Method for modeling circulation of malaria infection agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1681331A1 true SU1681331A1 (en) | 1991-09-30 |
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ID=21466709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU894730976A SU1681331A1 (en) | 1989-06-30 | 1989-06-30 | Method for modeling circulation of malaria infection agent |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1681331A1 (en) |
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1989
- 1989-06-30 SU SU894730976A patent/SU1681331A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Паразитологи , 1987, 12. № 2, 97-100. * |
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