SU1560219A1 - Method of treating endogenic intoxication of organism - Google Patents

Abstract

The invention relates to medicine and concerns the treatment of diseases associated with the appearance and circulation of toxic substances in the blood (peritonitis, sepsis, radiation sickness, etc.). The aim of the invention is to reduce the duration of treatment. This goal is achieved by the addition of estradiol dipropionate in combination with polybioline to the patient on the background of complex drug therapy, and after 1-2 hours cryoprecipitate in pharmacopoeial dosages and regimen. The proposed method allows to increase the efficiency of treatment of patients with endogenous intoxication of various origins, almost halving the duration of their treatment as compared with conventional methods.

Description

The invention relates to medicine and concerns the treatment of diseases associated with the appearance and circulation of toxic substances in the blood (peritonitis, sepsis, radiation sickness, etc.).

The aim of the invention is to reduce the treatment time by stimulating non-specific resistance of the organism.

This goal is achieved by adding extradiol dipropionate in combination with polybioline to the patient with endogenous intoxication of various origins against the background of complex drug therapy, and after 1-2 h cryopreiitis in pharmacopoeial dosages and regimen.

The method is carried out as follows.

After conducting a clinical and laboratory evaluation of the severity of intoxication,

based on the determination of the main parameters of the functional state of the mononuclear phagocytic system, namely: the content of circulating protein aggregates (CBA), the index of macrophage transformation of mononuclear cells (PMTM), phagocytosis of transformed macrophages (FTM), the intensity of absorption of circulating immune complexes (IPCCI) , the content of the CIC, toxic tests (paramecine time), and the establishment of indications for the treatment of endogenous intoxication is carried out by the introduction of extradiol dipropionate 2.0-3.0 ml of 2% pa target intramuscularly; the introduction of polybioline 400-500 mg intramuscularly, after 1-2 hours the introduction of single-group cryoprecipitate 200-400 IU intravenously; the introduction of other detoxification agents (single plasma and others)

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This scheme is performed once a day and, if necessary, can be repeated.

Example 1. Patient B., 57 years old, was admitted with complaints of pain in the right half of the abdomen, vomiting, dry mouth. The disease began acutely with pain in the right hypochondrium. With the deterioration of the general condition, the pain shifted to the right lower half of the abdomen. For several years, it has diabetes. Objectively: the general condition is severe. The skin is pale. Tongue dry, coated with bloom, breathing hard in the lungs. Right in the lower parts dry rales, pulse 96 per minute, rhythmic. HELL 130/90 mm RT. Art. The abdomen is swollen, tenderness on palpation in the right iliac region. Positive symptoms of peritoneal irritation. Peristalsis is not heard. The liver is enlarged, protrudes by 3 cm from the edge of the costal arch. The chair is arrested.

Laboratory data are given in table. one.

One hour after admission, the patient was operated on. Performed appendectomy. Drainage of the abdominal cavity. When her revision found purulent effusion up to 100 ml on the right flank. The vermiform process is gangrenous changed, on the top of the perforation, from which the intestinal contents. Clinical diagnosis: acute gangrenous perforated appendicitis, local non-demarcated peritonitis, moderate diabetes mellitus.

After surgery, the patient's condition worsened. Severe effects of endogenous intoxication Art. III. Detoxification was carried out according to the following scheme: in 12Sh - polybioline 500 mg intravenously, 1215 - extradiol dipropionate 2% - 2.0 ml intramuscularly, 14 ° - cryoprecipitate 400 IU intravenously, as well as other detoxification measures (single-group plasma , electrolytes, etc.). The next day, the patient's condition improved significantly. Slept at night. Mild pain in the wound area is preserved. Temperature 37.2 ° C, pulse 88 per minute, rhythmic; HELL 130/80 mm Hg. Art. The tongue is wet. The stomach is not swollen. Peristalsis of the intestines, separated by drainage up to 30 ml, is serous and transparent. After 3 weeks the wound healed. Clinical recovery.

Example 2. Sick D., 20 years old, was admitted to the hospital with a diagnosis of acute suppurative left-sided mastitis, sepsis. The general condition is severe. Adynamic, inhibited. The skin is pale, facial features are pointed. Temperature 39.8 ° С. Respiratory rate is 30 per minute, pulse is 112 per minute, BP is 90/60 mm Hg. Art. The liver is enlarged, protrudes from under

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edge of the costal arch 3 cm, painful. Diuresis 600 ml per day. Locally: the left mammary gland is infiltrated in the upper outer quadrant, sharply hyperemic, increased in volume. On palpation, infiltration and fluctuation in the upper outer and inner quadrants. From the nipple - purulent eemoe. Regional lymph nodes are enlarged, painful, lymphangitis. Laboratory data are reflected in the table. 2. After 2 days, the patient was operated on. Abscesses are opened and drained. Evacuated to 80 ml of pus. In crops - hemolytic staphylococcus. Intensive infusion and transfusion therapy, hemodez, albumin, antibiotics, sulfonamides were prescribed.

After surgery, the patient's condition is severe. The effects of severe endogenous intoxication persist: temperatures up to 39 ° C. Locally: postoperative wounds are covered with necrotic tissues, separated purulent, no granulations. On the periphery of wounds by hyperemia, infiltration. She was prescribed detoxification according to the following scheme: in 10 °° - estradiol dipropionate 2% - 3.0 ml intramuscularly and polybioline 400 mg intramuscularly and 11 °° - single-group cryoprecipitate 400 U intravenously. Transfusion is one-group plasma, other detoxification measures have been carried out.

On the same day, the patient's condition began to improve, and the effects of endogenous intoxication regressed. The patient became more active, according to the appetite. The temperature dropped to 37.2 ° C. Pulse 82 per minute, rhythmic. HELL 120/70 mm RT. Art. Wounds began to be cleansed of necrotic tissues, tissue hyperemia and tissue infiltration significantly decreased, and bright red granulations appeared on the periphery. Against the background of complex therapy, septic conditions were arrested. Detoxification scheme is repeated. Clinical recovery.

The proposed method allows to increase the efficiency of treatment of patients with endogenous intoxication of various origins, almost halving the duration of their treatment as compared with conventional methods.

Claims (1)

Invention Formula A method of treating endogenous intoxication of the body by administering a complex of drugs, including cryoprecipitate, characterized in that, in order to shorten the treatment time, the patient is additionally given estradiol dipropionate in combination with polybioline, and after 1-2 hours cryoprecipitate in pharmacopoeial acceptable dosages and regimen .