SU1513504A1 - Method of modeling cholelithiasis - Google Patents

Abstract

This invention relates to medicine, namely to surgery. The goal is to reduce the modeling time. To this end, dry exogenous cholesterol was administered orally to the animal at a dose of 0.2 g / kg. Simultaneously, a 40% carbon tetrachloride solution at the rate of 0.5 ml / kg of body weight is administered intramuscularly to the animal. The application of the method makes it possible to reduce the time needed for modeling cholelithiasis to 15-16 days.

Description

one

(21) 4293366 / 28-14

(22) 08/03/87

(46) 10/07/89. Bul K 37

(71) Chuvash State University named after Ilya I. Nova

(72) L.P.Ivanov and L.M.Timofeeva

(53) 613.475 (088.8)

(56) Vasilieva E.N. Questions of nutrition, 1976, No. 3, p. 6-11.

(54) METHOD FOR MODELING GUTNAL-STONE DISEASE

(57) The invention relates to medicine, namely to surgery. The goal is to reduce the modeling time. To this end, dry exogenous cholesterol was administered orally to the animal at a dose of 0.2 g / kg. Simultaneously, a 40% carbon tetrachloride solution at the rate of 0.5 ml / kg of body weight is administered intramuscularly to the animal. The application of the method makes it possible to reduce the time needed for modeling cholelithiasis to 15-16 days.

The invention relates to medicine, namely to surgery.

The purpose of the invention is to reduce the modeling time.

The method is carried out as follows.

in a way.

Exogenous dry cholesterol was orally administered orally at a dose of 0.2 g / kg daily for 15–16 days. Simultaneously, a 40% carbon tetrachloride solution at the rate of 0.5 ml / kg of body weight is administered intramuscularly to the animal.

Example .. A sea piggy weighing 552 g for 15 days was given orally dry exogenous cholesterol at a dose of 0.2 g / kg (104 mg) using a syringe. At the same time, 40% tetrachloride carbon was injected into this animal at the rate of 0.5 ml / kg of weight (0.11 ml) intramuscularly. After 15 days the guinea pig was killed. Biochemical research

showed blood cholesterol levels of 1.62 mmol / l, phospholipids 19.8 mmol / l, bilirubin 10.6 μm / l. In bile, cholesterol 128.64 mg%, total bile acids 2377.8 mg%. A microscopic examination of the bile revealed a microlith 2.0 x X 2.1 mm in size.

The application of the method makes it possible to reduce the time needed for modeling cholelithiasis to 15-16 days.

Formula

acquisitions

i

(L

sd

from cd

about

four;

A method of modeling cholelithiasis by administering chemicals to an animal, characterized in that, in order to shorten the modeling time, 0.5 ml / kg of 40% carbon tetrachloride and dry exogenous cholesterol in a dose of 0.2 g / kg are administered daily to the animal.

Claims (1)

Claim A method for modeling gallstone disease by administering chemicals to an animal, characterized in that, in order to reduce the simulation time, 0.5 ml / kg of 40 ^ carbon tetrachloride and dry exogenous cholesterol at a dose of 0.2 g / kg are daily administered to the animal.