SU1491514A1 - Method of treating syphilis - Google Patents

Abstract

The invention relates to medicine, in particular, to venereology, and can be used to treat syphilis. The aim of the invention is to reduce the duration of treatment. The goal is achieved due to the additional administration before the course of penicillin therapy in therapeutic doses of hemodez in the amount of 2-3 injections and sodium nucleinate for 16-32 days, and on the 5-6th day of penicillin therapy - the administration of a single BCG vaccine at a dose of 0.1 cm ³ . The invention makes it possible to shorten the treatment time for patients with syphilis by 6-14 days as compared with conventional methods.

Description

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The invention relates to medicine, in particular to venereology, and may be used to treat syphilis.

The purpose of the invention is to reduce the duration of treatment. This goal is achieved and the expense of additional administration before the course of penicillin therapy in therapeutic doses of hemodez in the amount of 2-3 infusions and sodium nucleniolate for 16-32 days, and on day 5-6 penicillin therapy is administered once 0.1 cm WAK1 (in BCG .

The method is carried out as follows.

Patients, regardless of the stage of syphilis and weight, are prescribed penicillin for 400,000 EUL around the clock in 3 hours, the dose of the primary seropositive and secondary fresh 520000 U units, the secondary recurrent and latent early 10000000 U units, the secondary recurrent and hidden early 10000000

At the same time, the following agents are prescribed that have an immunomodulatory effect.

Before starting the injection of penicillin, 400.0 hemodeza is intravenously administered intravenously, 2-3 times a day, with the help of which it is possible to carry out therapeutically to a certain extent. Correction of humoral immunity, detoxification, increased renal blood flow, increased glomerular filtration and, possibly, antigen and immune complexes.

During the entire course of treatment (16-32 days), patients take nucle4i

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sodium inat 0.1 3 ra a day, which has a stimulating effect on T and B immunity, increases the levels of lysolum, properdin, b-lysine and normal antibodies, stimulates the phagocytic activity of lymphocytes, has a detoxifying effect,

0.1 cm of BCG vaccine is administered intracutaneously once, which has a pronounced effect on phagocytic and cellular mechanisms; we have an immunity that sharply increases the body's nonspecific resistance to infection by increasing the production of antibodies.

At the same time, multivitamins are prescribed in standard doses „

Example 1, Ill 3 ,, 28 years old enrolled in venotdeleni.e regional skin and venereal dispenser with a diagnosis of secondary recurrent syphilis. DACs were sharply positive in a titer of 1: 160, RIBT - 84% positive, RIF and RIBabs positive. General clinical tests without pathology, excluding ESR (35 mm / h). In the cerebrospinal fluid minimally isolated pathologists. According to the results of immunological studies, significant immunosuppression in T and B immunity units, as well as a decrease in PAL were detected. The patient abuses alcohol. Clinical manifestations: a slim abundant roseolitis on the body, patulas on the palms and soles, wide condylomas on the genitals, polyadanitis. For the course of treatment, patients received penicillin 1020000005 (for 32 days), before starting the injection of the antibiotic, hemodez was administered twice daily in the amount of 2 intravenous infusions, and throughout the course, the patient received sodium nucleinate 0.1 3 times a day for 16 days , BCG vaccine 0.1 cm intracutaneously once, on the 5th day of treatment panhexavit 1d X 3 times a day. Roseolary rash regressed on day 5

treatment, papules in the palm of the hand on the 12th day, on the soles on the 18th day, condominal feces on the genitals on day 2A, by the end of the treatment, the polyadenitis completely regressed. The antibody titer in DAC by the end of treatment decreased to 1:20 and steadily negated 5 months after the end of treatment, the RIBT was negative a year after the treatment, RIF and RIBabs were slightly positive.

Example 2. Ill K., 32 years old enrolled in veterinary discharge with a diagnosis of secondary recurrent syphilis about DAC and RIBT is sharply positive. Objectively: roseolous rash on the body, polyadenitis. During the course of treatment, the patient received 102000000 PIECES of penicillin, 400 ml of hemodez in the amount of 3 infusions, simultaneously with the start of treatment with penicillin, sodium O, D X X nucleinate 3 times a day for 32 days. On the 6th day of penicillin therapy, the patient was administered once a BCG vaccine in an amount of 0.1 cm.

The treatment provided reduced the treatment time by 6-14 days.

The advantages of the method are illustrated by a table that shows the dynamics of the main indicators of the effectiveness of treating patients with the proposed method in a comparative aspect with the known (M ± n),

Claims (1)

Invention Formula A method for treating syphilis by administering penicillin, characterized in that, in order to shorten the treatment time, before the course of penicillin therapy, hemodez in the amount of 2-3 infusions and sodium nucleinate is additionally administered in therapeutic doses for 5-6 days penicillin therapy was administered once with 0.1 cm BCG vaccine. Average treatment time, days Total duration course: Hospital stay, d Average resolution time syphilides, days papules on the body papules on genitals x condyloma alopecia leucoderma Average time of negativity serological reactions to syphilis Complications 196, 1 P, 001 40 + A, 2 0.01 271.5128: 0.001 Eosinophils in 8% of patients