SU1459185A1 - Markedj thyroxine derivatives as reagent for radioimmune analysis and thyroxine/as derivatives intermediates for producing markedj thyroxine derivatives - Google Patents
Markedj thyroxine derivatives as reagent for radioimmune analysis and thyroxine/as derivatives intermediates for producing markedj thyroxine derivativesInfo
- Publication number
- SU1459185A1 SU1459185A1 SU4194965/04A SU4194965A SU1459185A1 SU 1459185 A1 SU1459185 A1 SU 1459185A1 SU 4194965/04 A SU4194965/04 A SU 4194965/04A SU 4194965 A SU4194965 A SU 4194965A SU 1459185 A1 SU1459185 A1 SU 1459185A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- thyroxine
- derivatives
- markedj
- semiproducts
- new
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
FIELD: radioactively marked compounds; more particularlyJ thyroxine derivatives of the general formula 1:a)- N; R- -CH; b) R- -OH; c)which can be used as reagents for radioimmune analysis. SUBSTANCE: new semiproducts of the general formula II:are wherein a); R- -CH; b) R- -OH; R-(CH)-CH-OH; c); R- -(CH)-CH-OH, prepared by reaction of N-acetylthyroxine N-oxysuccinimide ester and histamine dihydrochloride in aqueous in the presence of triethylamine. The compounds of the formula I are synthesized from said semiproducts by treatment with NaJ in the presence of phosphate buffer and chloroamine T in water followed by elution with 50% methanol. Radiochemical yield, % ; molar activity, KC/mole; radiochemical purity (% ): (a) 30; 1500-2000; > 95; (b) 35; 1500-2000: > 95; (c) 20; 3700-4000; > 90. New compounds are capable of being with antibodies to thyroxine and are not capable of being bonded to endogenous thyroxine binding protein. EFFECT: new semiproducts for the synthesis of markedJ semiproducts of the formula 1. 3 cl, 1 dwg, 2 tbl
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4194965/04A SU1459185A1 (en) | 1987-02-13 | 1987-02-13 | Markedj thyroxine derivatives as reagent for radioimmune analysis and thyroxine/as derivatives intermediates for producing markedj thyroxine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4194965/04A SU1459185A1 (en) | 1987-02-13 | 1987-02-13 | Markedj thyroxine derivatives as reagent for radioimmune analysis and thyroxine/as derivatives intermediates for producing markedj thyroxine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SU1459185A1 true SU1459185A1 (en) | 1994-02-15 |
Family
ID=60536378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU4194965/04A SU1459185A1 (en) | 1987-02-13 | 1987-02-13 | Markedj thyroxine derivatives as reagent for radioimmune analysis and thyroxine/as derivatives intermediates for producing markedj thyroxine derivatives |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU1459185A1 (en) |
-
1987
- 1987-02-13 SU SU4194965/04A patent/SU1459185A1/en active
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