SU1442189A1 - Method of differential diagnosis of exogenous-constructional and hypothalamic forms of female obesity - Google Patents

Abstract

The invention relates to medicine, to endocrinology, intended for the differential diagnosis of exogenous-constitutional and hypothalamic forms of obesity, which is necessary for the correct choice of treatment. The purpose of the invention is to improve the accuracy of the method. For this purpose, the dynamics of prolactin secretion for the administration of neuropeptide - luliberin is investigated by determining the initial level of the hormone in the venous blood sample and the subsequent intravenous injection of luliberin in a dose of 100 µg once. Then blood is tested for prolactin at 30, 60, 90, and 120th minute after drug administration. With an increase in the level of secretion in comparison with the initial one, a conclusion is drawn about the exogenous-constitutional obesity, and at a stable level in comparison with the initial one, the hypothalamic form of primary obesity is determined. The method allows correct diagnosis in controversial cases.

Description

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The invention is inclined to medicine, in particular to endocrinology, and can be used for the differential diagnosis of exogenous constitutional and hypothalamic obesity, which is necessary for choosing the right treatment.

The aim of the invention is to improve the accuracy of the method.

The method is carried out as follows.

After clinical examination in patients with obesity, the dynamics of prolactin secretion for the administration of neuropeptide - lyuliberin is investigated. To do this, patients are taken blood from a vein in which the initial level of the hormone is determined. Then it is injected into / into luliberin at a dose of iOO µg once and draw blood for 30, 60, 90 and 120 minutes to determine prolactin in it. Blood hormone levels produce a prolactin secretion curve, the nature of which is closely related to the form of obesity and, with an increase in secretion compared to baseline, exogenous-constitutional form of obesity is diagnosed, and at a stable level compared to baseline, the hypothalamic form primary obesity.

Example}. B. is sick; upon admission to the clinic, an exogenous-constitutional form of obesity was diagnosed. A study of the secretion of prolactin confirmed the clinical diagnosis.

The release of prolactin (PRL) in a patient in response to the introduction of luliberin during O, 30, 60, 90 and 120 minutes is 246, 1609, 856, and 500 mU / l.

Example 2. Ill., Upon admission to the clinic, exogenous constitutional obesity was diagnosed. Studies of the secretion of prolactin and confirmed the clinical diagnosis. The release of PRL in response to the introduction of luliberin during O, 30, 60, 90 and 120 minutes is 322, 722, 627, 414 and 421 mU / L.

Example 3. Ill A., when admitted to the clinic, a hypothalamic form of primary obesity was diagnosed. Research on the release of PRL in response to luliberin confirmed the clinical diagnosis.

During O, 30, 60, 90, and 120 min, the RLP emission is 180, 130, 150, 140, and 180 mU / L.

Example 4. Ill., Upon admission to the clinic, the hypothalamic form of primary obesity was diagnosed. Investigation of the release of PRL in response to lyuliberin. confirmed the clinical diagnosis.

Over time, 30; The 60, 90, and 120 min emissions of PRL are 391, 280, 270, 275, and 200 mU / l.

Example 5. Ill., Upon admission

The clinic has been diagnosed with an exogenous-constitutional form of primary obesity. The study of the release of PRL in response to luliberin revealed a reaction characteristic of patients with hypothalamic forms; - MY obesity. During the observation process, it was found that, despite the treatment, the patient remained overweight and after treatment, the lost weight returns to its original one. Significant changes in terms of normalization of EEG data against the background of weight loss are not

0 occurred, which is usually characteristic of patients with g-hypothalamic obesity. Thus, the initial clinical diagnosis (exogenous constitutional form of obesity) in patient O. on the basis of a study on the release of PRL and the response to luliberin was changed to the hypothalamic form of obesity. The correctness of this diagnosis was confirmed during the subsequent clinical observation and treatment of the patient.

Over time, 20, 60, 90 and 120 min

Q PLR amounted to 170, 170, 170, 150 and 120mU / L. The proposed method allows a correct diagnosis to be made in disputed cases.

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Claims (1)

Invention Formula The method of differential diagnosis of exogenous-constitutional and hypothalamic forms of primary obesity in women through clinical examination, characterized in that, in order to increase the accuracy of the method, luliberin is administered, the dynamics of prolactin secretion is investigated, and with an increase in prolactin secretion compared with baseline, exogenous-constitutional obesity is diagnosed, and stable level compared to baseline - hypothalamic form of primary obesity.