SU1438789A1 - Method of treatment of cardiac rhythm disturbances - Google Patents

Description

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The invention relates to medicine, in particular to the cardinal loop, and concerns the treatment of disorders of heart rita.

The purpose of the invention is to reduce the duration of treatment and reduce the frequency of sediments.

The goal is to achieve that, in the treatment of irregular heart rhythms by administering antirhythmics, 600–900 mg of tracerne in the patient are given dimethylsulfoxnd in the lake at the same time once a day.

The method is carried out as follows.

Pastry size m. Mm with a colored gauze cloth with a size of 3-4 millimeters thick; (layers) with an antiarrhythmic agent applied on it and 600–900 mg of dimethyl sulfoxide are glued onto the skin of the patient's precardiac region,

The efficiency is monitored visually on the monitor and simultaneous daily recording on a magnetic tape.

Example-, Patient S., 65 years old, was admitted to the hospital with complaints of compressed pain in the heart area, rapid heartbeat, dizziness, shortness of time; left ventricle.

According to the data of complaints, an objective examination of pedophilia, laboratory and instrumental examinations, there is a diagnosis of chronic disease: coronary ischemic heart disease, angina pectoris and rest, frequent attacks; atherosclerosis of the aorta, KopoHHpHiiix arteries; athero-sk. -therotic and post-infarction car-dioskleroe, NL1.B. Congestive heart failure. Complex rhythm disturbance.

The condition of the patient is caused by cicatricial cardiosclerosis (a significant disruption of the contractility of the m) of the cardiac), a complex rhythm disturbance, which causes a severe hemodynamic disturbance. “The arterial pressure fluctuated within 90/50 - 80/50 mm Hg. Intravenous injection of antiarrhythmic prep.chratov to restore

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 ") Yuli; heart rate was contraindicated due to the possible development of cardlogenic collans and secondary terminal arrhythms; In order to restore the HopMajibHoro rhythm of the heart to the skin of the nrecardial area, a patch of 100 mm in size was applied with a 5050 mm thick gauze pad with a thickness of 3-4 mm (4-5 layers) with a rhythmicin (disopyramide) applied on it a dose of 150 and 600 mg of dimethyl sulfoxide.

According to the data of the electrocardiogram magnetoscopy, after 20 min, the stable sygus rhythm was restored. Ventricular tachycardia is cropped, atrio-wind dissociation disappeared, blood pressure stabilized at 15/80 mm Hg. At the control transesophageal OY ECG, a physiologically normal heart rhythm was recorded. There were no complications and no effects. Discharged for outpatient treatment. According to the follow-up follow-up, there were no heart rhythm disturbances.

PRI me R 2, Patient K., 64 years old, was admitted to hospital with complaints of intense compressive pains during grueling, not relieved by taking nitroglycerin under the tongue, heartbeat, interruptions in heart activity, nausea, dizziness . According to laboratory and instrumental studies, a diagnosis was made: ischemic heart disease; repeated large-focal penetrating myocardial infarction in the anterolateral wall of the left ventricle; atherosclerosis of the aorta, coronary arteries; atherosclerotic and postinfarction cardiosclerosis, NP. Impaired excitability by paroxysmal atrial tachyarrhythmias, Apit schich collapse. State of admission heavy. Pulse up to i50 beats per 1 min, arrhythmic. Blood pressure ranged from 80/50 - 70 / / 50 h№t Hg, Art.

In order to restore sinus rhythm to the patient on the skin of precardial 30

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An area of 100.100 mm in size was applied to the region with a gauze napkin 50g50 mm in size, 3-4 mm thick (4-5 layers) with antiarrhythmic agent applied on it - Aymapine (gilurithmal), in a dose of 150 and 900 mg of dimethyl sulfoxide, after 50 min rhythm restored.

Against the background of the restoration of the physiologically normal sinus rhythm in a patient and echizli, anginal pain, the arterial pressure was normalized and stabilized at a level of 120/80 mm Hg. Relapse of arrhythmia was not observed. Complications and side-. No reactions were noted. Subsequently, the course of a heart attack without complications, I mastered physical exertion in the form of a rise on the 3rd floor and a walk to 3000m. For further treatment, he was transferred to a rehabilitation unit for 28 days.

Froze Patient K., 74 years old, was hospitalized with complaints of frequent piercing-compressive heart pain, frequent heart attack, shortness of breath, and lower limb stacks. For about 15 years, he noted arrhythmia, about which he took various antiarrhythmic drugs on an outpatient basis. The last three days alone could not arrest arrhythmia. The ambulance crew delivered to the hospital in connection with intractable paroxysm of arrhythmia and the development of acute left ventricular failure (cardiac asthma) against the background of the introduction of antiarrhythmic drugs.

Based on complaints, objective research, laboratory and instrumental data, the diagnosis was made: chronic ischemic heart disease, arr. comb shape; atherosclerosis of the aorta, coronary arteries; atherosclerotic and myocardic cardiosclerosis, NPB; supraventricular tachycardia, polytopic polymorphous polymorphism.

According to the ECG data on the magnetic tape, the patient was registered with supraventricular tachycardia, polytopic multifocus distraction. In order to restore the sinus rhythm, the patient was put a patch on the skin of the precardiac area 100x100 mm in size with a mm gauze pad 3–4 mm thick (4–5 layers) with a glued

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on it antiarrhythmic drug - novocaine number 5 at a dose of 1000 and 6000 mg of dimethyl sulfoxide. ,

According to the monitoring monitor with a recording on the patient's magnetic tape after 35 minutes, the stable sinus rhythm was restored. Blood pressure normalized and stabilized at 140/80 mm Hg. Complications and side effects. x reactions were observed. Recurrent arrhythm1 was not. Discharged in satisfactory condition on the i7th day.

15 Thus, in example 1, the use of P) of the proposed method allowed quickly and effectively arresting complex heart rate rhythm (ventricular vascular 20 days in combination with the atrioventricular dissociation with interference) in a patient with severe illness: myocardium (large-focal post-infarction cardiosclerosis with aneurysm outcome

25 anterolateral stenus of the left ventricle) and significant hemodynamic disturbances in which the use of antiarrhythmic drugs is intravenously contraindicated due to the high risk of the development of reactive collapse, secondary} and sudden death, and oral administration of antiarrhythmic drugs. imperceptibly in the urgent plaque due to prolonged absorption and partial destruction in the stomach and liver.

In example 2, it is shown that the use of the proposed method also made it possible to quickly and effectively arrest a heart rhythm disorder (paroxysm of atrial fibrillation) in a patient in the acute period of a large-focal penetrating repeated myocardial infarction.

45 collapse, when the use of antiparts of intravenous proinoposcopy is due to the high risk of reactive collapse, asystole and death of the patient, and their oral use is ineffective for the reasons indicated.

Example 3 shows that the application of the proposed method made it possible to quickly and e (1x |:)

55 recurrent complex rhythm itapymeraie (supraventricular rhythm of tachycardia and polytopy much (extrasystoles) in patients with atherosclerotic and myocardial tricycosis 35

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roeoma, severe congestive heart failure, and hemolinic disorders,

The proposed method allows you to quickly and effectively arrest the most diverse cardiac rhythm disorders: ventricular tachycardia in combination with atrioventricular dissociation with interference (example 1); atrial tachyarrhythmia (example -2); supraventricular tachycardia in combination with polytopic multifocal extracystole (example 3) in patients with different lesions of hn myocardium: croup noocardial postinfarction and cardiac sclerosis with chronic postinfarction aneurysm (example 1); repeated,

A method of treating cardiac arrhythmias by administering to a patient

macroscopic anterior-lateral myocardial infarction in acute acute anti-arrhythmic agents, about tl and - period (example 2); atherosclerotic so that, in order to cue and myocarditis cardiosclerosis and congestive heart failure (example 3), use different

reducing the duration of treatment and reducing the incidence of complications, the antiarrhythmic drug is administered into the precardial 25th zone transdermally in combination with dimethyl sulfoxide in the pharmacopayne permissible dosage and ratio

antiarrhythmic drugs (rhythmylen, aymalin, procainamine) and effectively prevent complications and adverse reactions

shares characteristic for the latter. The treatment time was reduced by 1.5 times.

When using the proposed method of complications and adverse reactions were observed. Therefore, it can be recommended for the treatment and prevention of cardiac arrhythmias both in the hospital and in the clinic. Using the proposed method of treatment, the patient can in some situations and independently prevent recurrences of cardiac arrhythmias,

Claims (1)

Invention Formula A method of treating cardiac arrhythmias by administering to a patient antiarrhythmic drugs, about t and the fact that, with the aim of antiarrhythmic drugs, about t and the fact that, with the aim of In order to reduce the treatment time and reduce the incidence of complications, the antiarrhythmic drug is administered transdermally in the precardiac zone in combination with dimethyl sulfoxide in pharmacopoeially acceptable dosages and ratios.