SU1424847A1 - Method of producing radiopaque agent - Google Patents

Abstract

In order to increase the radiopaque properties of the agent in the study of the colon, barium sulfate powder with a particle size of 0.1-2.5 µm is mixed (wt.%) With trisodium citrate 0.35-0.45, sorbitol 0.2-0, 3, polymethylsiloxane 0.05-0.1 and water. The slurry is dried, gum arabic 2.1-2.3 is added and ground. 1 tab.

Description

The invention relates to the field of medicine, namely to X-ray diagnostics, and can be used in the preparation of a radiopaque agent for the study of the colon in double contrast conditions.

The aim of the invention is to improve the radiopaque properties of the means for studying the mucous membrane of the large intestine.

The method is carried out as follows.

The barium sulphate treatment is carried out in a device that provides a high speed of rotation of the working bodies. UDA-lab disintegrator 10 is used for this. At a certain rotational speed of the apparatus working parts, starting from 1 7000 5 / min, qualitative changes in the powder structure occur, resulting in aggregates of various irregular shapes with sizes of 0.1 - 2.5 um Such aggregates during the preparation of the suspension with its subsequent drying and re-grinding in a WESTERN mill become even more inhomogeneous. This all makes it possible to obtain a suspension with a density of 170% by weight of vol. 1 is the most optimal speed vrash;

rotors disintegrator rat 1 7000 rpm,. which corresponds to the counter speed of the last but one row of work elements 285 m / s. Special additives are then added to the powder (sodium citrate 3 g, sorbitol 2 g, polymethylsiloxane 3 ml) and an aqueous suspension is prepared for 225 ml of water and 750 g of dry powder. The suspension is thoroughly stirred for 10-12 minutes. Then, the resulting suspension is dried at room temperature for 20-24 hours. 15 g of gum arabic is added to the resulting mass and crushed for 1 hour in a ball mill at a ramp speed of 2.5 rev / s. The powder thus obtained is sifted through a No. 29 sieve and stored. Drying the primary suspension and re-grinding the powder is necessary to increase the density of the suspension directly used in studies of the colon wall under conditions of double contrast.

The studied mixtures with the following composition are given in the table.

0

five

0

five

With a decrease in the mass percentage of trisodium citrate and sorbitol, the density of the barium sulfate suspension decreases. At the same time, surface changes on radiographs are not detected, since the covering layer is too thick. With increasing weight percent of these additives, the density of the suspension increases. However, the suspension becomes too viscous, the flowability is significantly reduced, which impairs adhesion to the mucosa.

With a decrease in the mass percentage of polymethylsiloxane on the X-ray diffraction patterns, gas bubbles are detected. Increasing the mass percentage does not make sense, since 0.05-0.10 wt.% Already removes gas bubbles.

Fewer gum arabi; but does not prevent the reverse resorption of water from the intestinal wall and therefore promotes the formation of plaque. With increasing weight percent, the properties of the slurry do not improve.

The radiopaque agent prepared according to the proposed method allows the X-ray anatomical and X-ray functional signs of the colon to be more fully expressed in comparison with the use of conventional barium sulfate prescription. This is achieved by the fact that the selected ratio of additives significantly increases the adhesive properties of the drug, creates optimal conditions for its interaction with the surface.

mucous membrane of thick KIP1KI.

As a result, the relief of the mucous membrane on radiographs is contrasted much more qualitatively than in radiographic images of the large intestine obtained using traditional bari. The high homogeneity of the drug, caused by the task-t range of particle size, virtually eliminates the effects of layering images of the folds of the mucous membrane or makes it easy to visually distinguish them from each other. Good fluidity of the drug contributes to its penetration into the smallest interstitial spaces.

Claims (1)

5 claims The method of obtaining a radiopaque agent by grinding barium sulfate; Addition of trisubstituted five 0 five 0 sodium citrate, sorbitol of the propellant and stabilizer, characterized in that, in order to increase the radiocontrast properties of the thick-top specimen, the grinding of barium sulfate is carried out to obtain a powder with a particle size of 0.1-2.5 µm, by adding yut as a stabilizer gum arabic, and antifoam - polymethylsiloxane in the following ratio of components, wt.%: Sodium trisodium citrate 0.35-0.45 Sorbitite 0.2-0.3 Polymethylsiloxane 0.05-0.1 Gum arabic 2.1-2.3 Bari sulfate Else Sodium trisodium citrate Sorbitol Polymethylsiloxane Gum arabic 0.15-0.250.25-0.35 0.35-0.450.45-0.55 0.55-0.65 0.05-0.100.1-0.2 0.2-0.3 0.3-0.4 0.4-0.5 0.001-0.0050.005-0.050 0.05-0.10 0.10-0.15 0.15-0.25 1.7-1.91.9-1.2 2.1-2.3 2.3-2.5 2.5-2.7 Editor L.Gratillo Compiled by A. Petsko Tehred L. Serdyukova Order 4710/6 Circulation 655 VNIIPI USSR State Committee for inventions and discoveries 13035, Moscow, Zh-35, Raushsk nab. 4/5 Proofreader N. Musk Subscription