SU1382478A1 - Method of treatment of extrapyramidal diseases - Google Patents

Abstract

This invention relates to medicine, in particular to neurology for reducing jitter, rigidity and akinesia while reducing side effects. In addition to drugs acting on the neurotransmitter systems of subcortical structures, verochpyron is additionally administered.

Description

The invention relates to medicine, namely to neurology.

The purpose of the invention is to reduce trembling, rigidity and akinesia while reducing the side effects of drugs.

Example 1. Patient I, 62 years old, retired. The outpatient was examined on February 21, 1986. Ill for three years. Onset of the disease with trembling in the left hand, increased fatigue. Soon the slowness in walking joined. Diagnosis: parkinsonism. At first, the disease was moderately progressive and the doses of the drugs taken were small. But since December 1985, stiffness of the lower part of the face increased, speech and writing deteriorated, and stiffness of the leg muscles increased. Increasing the dose of L-Dov to 0.5x4 times in 1 day somewhat reduced these symptoms. Side effects in the form of nausea limited the dose of L-DOPA.

On examination on February 21, 1986, Ami noted small static tremor in the left extremities (10 points), violation of the letter. Extrapyramidal tone of the type of gear in the left limbs (14 points). Gait slowed down, achaeurokinesis. Speech is little modulated. The total score is 93.

Diagnosis: vascular parkinsonism, stiff jerky form, stage II.

In addition to the received therapy (L-Dopa 0.5x3-4 times, cyclodol 0.002 x3 times a day), veroshpiron was prescribed

0,025x2 times (50 mg) for 15 days.

A re-examination of 03.24.86 g after treatment for 15 days revealed a significant improvement in the condition, which began two weeks after starting to take the peaks of the pyrone: stiffness passed in the lower jaw, speech improved, stiffness in the left hand decreased (7 points), in the lower limbs, muscle tone has normalized, there is practically no yeast. He walks in quick steps, Ami has decreased. The total score of lesions is 22. Stage I lesions are established.

Follow-up examination on 05/20/86, 2 months after the course of treatment with veroshpyron: satisfactory condition. In the background continue

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Stable stable administration of L-Dopa 0.5x3 times and cyclodol 0.002x3 times a day do not exhibit clinically symptoms of parkinsonism (trembling O points, rigidity O points). The total score of damage is 0. It is recommended to reduce the maintenance doses of the drugs taken.

Example 2. Patient E-ko, 55 years old, disabled person of group II. It is observed on an outpatient basis since 03/04/86. Ill for 10 years. In 1975, he suffered severe viral flu with high fever, headache, and drowsiness. According to the patient, the day was unconscious. After recovery, I immediately noticed that I began to write slowly. Soon the speech changed: it became slow and unintelligible, and then it became difficult to move because of the general constraint. Since 1975, the diagnosis: parkinsonism. And from that time I took L-Dopa 0.5x3 times a day. Since 1980, due to a decrease in the effect of L-dopa, Madopar takes 125x4 times and parkopan 0.02x4 times in 1 day. All these years, the state has been fairly stable and has been corrected by ongoing drug therapy. In 1985, stiffness began to grow, disability was disturbed. Was determined

Group II disability.

 When viewed 04.03.86 g, the asymmetry of the face is easy, lack of convergence on the left. The face is masklike. The voice is deaf, the speech is poorly legible. Expressed akinetic-rigid syndrome, mainly in the right extremities. Extrapyramidal tone is greater in the right extremities (rigidity 21 points, akinesia 27 points). Walking in small steps, propulsion, achaeurokinesis. The total score is 115.

Diagnosis: post-encephalitic parkinsonism, akinetik-rigid form,

III degree.

In addition to the constant doses of drugs (madopar - 125x4 times and parkopan 0.002x4 times in 1 day), Verochpyrone 0.025x3 times in 1 day (75 mg) was prescribed for 20 days.

When viewed on 14.03.86 g after a 20-day course of treatment: akinesia significantly decreased (9 points), walks more freely, there is no propulsion. Stiffness and extrapyramidal1

the tone in the most severe limbs sharply decreased sharply (from 21 to 3 points), the prangy arm remains at the level of 14 balloon. Ospda total points 66. Zreg Istriror ako defeat reduction to TI s; tag1eni. The beginning of the improvement of the condition was noted by the patients 10 days after the start of Verohspiron. On examination 14. 04. 86 (2 weeks after the course of treatment with verospiron), the state is satisfactory. There is only a small amimi, a non-cut pronounced akinesi, slightly amedlecha speech. Minor tone in the right hand is normal, in the left hand there is H. b .; sha constraint (3 points). OGltz, the score of the lesion is 50. The daily daily dose of steam is reduced to 125 from 4 to 3 kapsum and Larry 0.002 to 3 times a day.

When viewed on 05/14/86 i (four) e, 1.5 months after the course of treatment was performed by veroshpiron), there is a harassing improvement in the overall coherence. Registered reduction is affected (loo t gty fines.

Example 3, BojibHofi 11-, 45 years. Ambulatum orno, dated January 09, 1986. Ill for three years. Nachpgk; the disease is gradual, with slusopism in the extremities, slower movements. For the first two years, he didn’t try to move more, to deal with physical exercise. During the last year, he noted a slowing down of CP1, trembling in hands and rapid Haii-inraction of stiffness, in connection with Part 1 he took cyclodol 0.002x3 and m titer pairs - 125x3 per day. In connection with r a growing scrubber, in the last 1.5 months has increased the dose of mapoplars - 125 to 9 capsules in 1 day to maintain performance.

On examination of 09.01.86 g, the patient is depressed with his condition, depressed. Ammonic face. The voice is deaf and quiet. Movement dramatically slowed down, Walking bent over with small steps. Acheirokinesis. Small static tremor in the fingers. Plastic

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tonus of limbs, more to the left. (NTSC score of 75.

Piagnoch; Parkinson's disease, akyne-nego-rigid syndrome, III degree.

ep (1G endorano treatment: cyclodol, 0.002x3 times in 1 day, reduce the dose of madopar - 125 from 9 to 3 capsules in 1 day and add weroshpiron to 0.025xL times 20 days (100 mg).

On examination of 24.03.86 g, the recommended treatment was carried out.

The condition is satisfactory, ac: p :) good. Significantly diminished — I was stiff. Muscular tone in the limbs was normalized, cleared slightly elevated in the left f-sides: i 1 x. Decreased Amymi, it became zuchnoy speech. No shivering. There is a chipboard. mn quickly. The sum of the scores of the disease decreased to 33. The registra- tion of the degree of manifestation of the disease from III to I degree decreased. A significant decrease in the manifestations of Zlpp Ts-ani was noted in patients through a hint of nelyo from the start of treatment with OO i J,

 On 13.05.86 g examination (after 1.3 1 EC after the course of treatment with veroshpiriono i), the mood is good and the condition continues to improve. Reduces the dose of drugs: at home on weekends it takes only 2 times a day, m-1dg) par-125 and diclodol 0.002x2 times, at work the diclodol vine increases to 3 tab. A small number of left-handedness remained (3 points), chmimi, elements of akinesis. Speech fully normalized. By-; erk good. The amount of points is amazing; and iz it up to 19.

Claims (1)

Invention Formula A method for treating advanced diseases by administering drug BeHHf.ir. means of affecting the noir (mediator systems of subcortical structures, distinguished by the fact that, in order to reduce trembling, rigidity and akinesia, while reducing the side effects of drugs, aepoFjnupoH is additionally administered. VNIIPI Order 1243/4 Random polygons pr - tie, Uzhgorod, st. Project, 4 Circulation 655 Subscription