SU1353441A1 - Method of prophylaxis of acute respiratory diseases of children - Google Patents

Abstract

This invention relates to pediatrics. The purpose of the invention is to reduce the incidence. Leukocyte interferon is administered to the thigh by electrophoresis. The interval between the first and second administration is 1-2 days. Subsequent injections are carried out throughout the entire period of elevation of respiratory diseases with an interval of 7-10 days, 3-4 times or more, depending on the duration of the outbreak. 4 tab. from 01 O5 4 4

Description

The invention relates to medicine, namely to pediatrics.

The aim of the invention is to reduce the incidence due to the introduction of interferon by the electrophoretic method in the thigh region.

The method is carried out as follows.

The kidney on the inner and outer surface of the thigh parallel to impose electrodes 100 cm in size. The negative pole is connected to the electrode superimposed on the inner surface of the thigh. After applying the electrodes, the thigh is flexed with a rubber bandage.

The administration of human concentrated leukocyte interferon is carried out from the negative pole. Interferon with an activity of 50 thousand units / ml is used. Immediately before the procedure, interferon is diluted to a concentration of 2 thousand units / ml with distilled water. The current density of 0.05 ml / cm area of the strip. The duration of the session is 10-15 minutes. The introduction is carried out during the entire period of the increase of the acute respiratory disease with an interval of 7-10 days, 3-4 times or more, depending on the duration of the outbreak.

Example 1. A child is 10 years old, prophylactic administration of interferon was carried out by electrophoretic method 4 times with an interval of 7-10 days, a single dose of 5 thousand units. course - 20 thousand units The introduction was carried out on the area of the right thigh, laced with a rubber bandage. Current 5 mA duration of procedure 10 min.

Acutely ill, cough, runny nose, temperature 37.0 ° C, catarrhal changes in the throat. Intoxication phenomena were absent. From the internal organs of the pathology is not detected. Diagnosis: acute respiratory disease, mild form. Symptomatic treatment was prescribed (cough mixture, nasal drops). The temperature was kept for 4 hours, i.e. less than one day. Cough, runny nose disappeared after 2 days. The duration of the entire disease is 3 days. There were no complications.

Example 2. A child of 10 years old, acutely ill, headache, cough, runny nose, temperature 37 ° C, catarrhal changes in the pharynx. The phenomena of intoxication are expressed moderately. From the internal organs of the pathology is not detected. Diagnosis: acute respiratory disease, mild form. Supplemental therapy was prescribed (cough syrup, gargling with furacilin, nose drops). Interferon is not administered. The temperature was kept on low-grade figures for 3 days. Catarrhal symptoms within 7 days. The disease duration is 7 days. Complications not found.

As can be seen from examples 1 and 2, the duration of the disease in a child who received interferon for prophylactic purposes is shorter (3 days), which the child from the control group received, the disease continued for 7 days.

Example 3. A child of 10 years old, a prophylactic administration of human concentrated interferon was carried out with the parameters presented in Table. one.

Ill acutely during the rise of acute respiratory diseases in school. A river has a cough, runny nose, temperature 37.8 ° C, catarrhal changes in the throat. Intoxication was absent. With

5 side of the internal organs of the pathology is not detected. Diagnosis: acute respiratory disease, mild form. Symptomatic treatment was prescribed (cough mixture, nasal drops).

As can be seen from the above scheme, the procedures were carried out 1 time in 7 days with a single dose of interferon 5 thousand units, with a duration of 10 minutes. This prevention did not protect the child from the disease, but the disease was easy, without any symptoms.

intoxication with subfebrile temperature. The temperature was kept for 6 hours. Cough, runny nose disappeared after 2 days. The duration of the disease is 4 days. There were no complications.

Example 4. The child, during the rise of seasonal acute respiratory diseases at school, received interferon prophylaxis by electrophoresis with the data given in Table. 2 physiotherapeutic parameters.

As can be seen from example 4, the introduction of in5 terferon was carried out at a dose of 7.5 thousand units. the duration of the procedure is 15 minutes and the interval between treatments is 7-9 days. The child had close contact with patients with acute respiratory diseases, but having received prophylaxis with interferon, did not

0

got sick

Example 5. A child of 9 years old, in the period of recovery of acute respiratory diseases, had close contact with patients and received a prophylaxis with physiotherapeutic parameters presented in Table. 3

In this case, prevention has proven effective. The child did not get sick. As can be seen from Example 5, the single dose of interferon is 7.5 thousand units, the duration of the procedure is 15 minutes, the intervals between administrations are extended to 10 days.

The given examples show that prophylaxis with interferon with a frequency of administration of 1 time in 7-10 days, a procedure duration of 10-15 minutes and an interferon dose of 5.0-7.5 thousand units. turns out to be effective. Increasing the dose of interferon and the duration of the procedures is not advisable, since the use of these parameters reduces the incidence or the disease is mild.

Thus, the use of the proposed method provides an increase in the prophylactic effect of interferon, allows to significantly reduce the incidence of acute respiratory diseases. The incidence under the influence of interferon administered internally by droplet or aerosol is reduced

but also in polyclinics, since the introduction of interferon once a week is sufficient.

Data showing a decrease in the incidence of seasonal acute respiratory infections under the influence of prophylactic use of human concentrated leukocyte interferon are given in Table. four.

Claims (1)

Invention Formula Method for the prevention of acute respiratory diseases in children by administering 2-3.5 times, when using the proposed O leukocyte interferon, a different method - 4.3 times, which is increased by the fact that, in order to reduce morbidity, the effectiveness of prophylactic leukocyte interferon is introduced concentrated leukocyte interferon by electrophoresis 1.2-2.1 times and allows - “with It does not use interferon not only under the conditions of an organized children's collective area of the hip using the electrophoretic method at a dose of 5.0–7.5 thousand units. at a current density of 0.05 mA / cm, a pad size of 100 cm for 10-15 minutes with intervals between administrations of 7-10 days. 7500 7500 7500 5 5 5 but also in polyclinics, since the introduction of interferon once a week is sufficient. Data showing a decrease in the incidence of seasonal acute respiratory infections under the influence of prophylactic use of human concentrated leukocyte interferon are given in Table. four. Invention Formula Method for the prevention of acute respiratory diseases in children by administering leukocyte interferon, characterized in that, in order to reduce the incidence, leukocyte interferon is administered in leukocyte interferon, characterized in that, in order to reduce the incidence, leukocyte interferon is administered in hip area by electrophoretic method in a dose of 5.0-7.5 thousand units at a current density of 0.05 mA / cm, a pad size of 100 cm for 10-15 minutes with intervals between administrations of 7-10 days. Table 1 No no no Internasal drip In the form of an aerosol Electrophoresis method Table 4 2.2 2.0 2.1 3.5 4.3