SU1249024A1 - Method for synthesis of functional magnetic latexes - Google Patents

Description

one

The invention relates to the chemistry of polymers, and specifically to methods for synthesizing functional magnetic latexes for the purpose of using them as matrices for separating biological objects.

The purpose of the invention is to obtain functional magnetic latexes highly filled with magnetite (up to 75iCHrCHyCHz-CHj CHr, -CHi OCOCiiHg COOH

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obtained according to examples 14 and 15, and 4 ml of water are dispersed by ultrasound (22 kHz) for 2.5 minutes while cooling with flowing water (15–20 s). 0.2 ml of styrene is added and the voice is continued for 15 minutes while cooling. At the same time, polymerization proceeds.

0.1 ml (1.5 mmol) of acrolein n is polymerized by sonication and cooling for 10 minutes. 2 min. Sounded without cooling to distill off the residual monomers. A copolymer latex with an average particle diameter of 0.1 μm is obtained. The thickness of the layer of polyacrolein 0.02 microns. The amount of magnetite 80% by weight of the polymer. The output (total) of the polymer is 0.25 g (84% of theory). The presence of functional aldehyde groups on the surface of the latex particles is determined by reaction with fuchsinsernis-α. that acid. The latex particles are analyzed by electron microscope.

Example 2. The process is carried out as described in Example 1. 0.15 g (1.6 mmol) of methyl methacrylate is taken as the basic monomer, 0.3 ml (10%) of ferrofluid and 0.1 g of polymer I are used as magnetite. average particle diameter of 0.08 μm, the content of magnetite 75% by weight of the polymer .. The polymer yield 0.23 g (93% of theory).

Example 3. A mixture of 0.4 g of water magnetite (25.7%), 0.02 g of Polymer I (under the conditions of Example 1) and 4 ml of water is dispersed by ultrasound for 4 minutes. 0.2 ml of styrene is added and polymerized at dubbing (22 kHz) 15 min while cooling. 0.1 ml of acrolein is added and voiced for 10 minutes. Remove the cooling, voiced for 2 minutes. Formed latex with a diameter of 0.06 microns.

2490242

80 wt.%), As well as simplifying the process by eliminating the stage of purification of the final product from the monomer and carrying out polymerization without introducing 5 additional initiator clay.

Example 1. A mixture of 0.03 g of an aqueous suspension of magnetite, 0.02 g of polymer I of the following formula

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0

S

The mass of magnetite-containing particles is 75% by weight of the polymer. Sediment 60 wt.% By weight of latex (by dry residue). The total yield of 80%. Of theory.

Examples 4-9. The process is carried out analogously to example 1.

The performance of the obtained latex is shown in the table.

Example 10. Take 0.01 g of copolymer I in 4 ml of water. Sonicate for 1 min at. Add 0.2 ml of styrene, voice for 20 minutes while cooling, add 0.1 ml of acrolein and voice for another 10 minutes. Polymer yield (after stripping of monomers and solvent) is in the order of 0.0017 g (less than 1% of theory).

Example 11. Take 0.03 g of an aqueous suspension of magnetite, 0.02 g of a copolymer of butyl acrylate with acrylic acid and dimethylvinyl ethylmethyl tert-butyl peroxide and 4 ml of water. Sounded for 25 minutes with 0.2 ml of styrene added, sounded for 15 minutes, 0.1 ml of acrolein added, sounded for 10 minutes (all at 10 ° C). After distillation of the monomers, the total copolymer yield is 0.0017 g (less than 1% of theory). Coagulum 30%. The content of magnetite-filled particles is less than 3%.

Example 12. The process is carried out analogously to example 11, but the polymerization is carried out at. The polymer yield of 0.012 g (6.8% of theory on styrene), Coagulum 30%. The content of magnetitin-filled particles is less than 15%.

Example 13 (lime) To a mixture of 8% acrolein, 0.5% polyglutaric aldehyde, NaPZO in 20 ml of aqueous 5% ferrofluid is added dropwise. NaOH to pH 10.5. Mixture

31249024

stirred for 2 hours. Receive magnetite dim (V thuy 3.3 0, vayu Po l syden AK

containing latex with an average particle diameter of 0.04 microns. The product is dialyzed and separated from the magnet-containing particles with a magnet. The polymer yield 1.5 g (94% of theory). 100m of product is mixed with 4 ml of a mixture containing 9% acrolein and 0.5% polyethylene oxide (mol.m. 100,000) in water. The solution is degassed from oxygen by purging with argon for 20 minutes and irradiated at a source of Co (1 Mrad). Magnetic polyacrolein particles are obtained, which are the initial latex with the polyacrolein microbeads grafted on its surface. The polymer yield in the second stage of 0.35 g (89% of theory). The share of magnetite in the final product 50 wt.%.

The initiator emulsifier used in accordance with the proposed method is obtained by copolymerization of butyl acry4 5.

44 25 31 9300 СТ 55 .35 10 10000 СТ

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57 35 8 11200

Editor N. Rogulich

Compiled by V. Semeni Tehred N. Bonkalo

Order 4197/25 Circulation 470Subscription

VNIIPI. USSR State Committee

for inventions and discoveries 113035, Moscow, Zh-35, Raushsk - nab., 4/5

Production and printing company, Zdga Srod, Proektna St., 4

Lats: (BA) -, dimethylBi; -: (VEG) in terms of Argopo 3,3 - EHT, 0, - 3 hours from Pol. whether: - eri; at si of 53%, With denm prod AK 35, BL

And .r I-I Chuu argon: 3.3 g VEG, 0.28 g trg-duva: t :: - 1 -; merpzugO g; . 62%, Soder :: sedimentation), BA: -.

acrylic acid () and the ethinyl hydroperoxide ring following the procedure.

ep 1 -1. In the ampoule, the product-:. Pomeggayut 20 g of acetone,

6.7 g AK, 13.5 g BA and dodecium.1: mercaptaia. We blow with argon, sealed, for 13 h at 60 s. Conversion agent (after repacking), wt%: EEG 10, 55. Mol. 10,000

ep 15, In a vial, purge placed 25 g of acetone,

3.4 g AK, 7.3 g BA and u-dodets -: lmercaptan. Pro; vproHo: .i, sealed, poly- 2 h ol :: 60 ° C. Converse

pn-1e links (after over-May.%: ZEG 31s AK 25,

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Low output

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740

Proofreader V. Booth ha

Claims (1)

METHOD FOR SYNTHESIS OF FUNCTIONAL MAGNETIC LATEXES by radical emulsion polymerization of styrene or methyl ether (methacrylic acid in an aqueous dispersion of magnetite in the presence of an emulsifier and an initiator, followed by grafting of acrolein onto the obtained product with stirring, characterized in that, to simplify the method and increase the amount in latex, as an emulsifier and simultaneously an initiator, a copolymer of butyl acrylate, acrylic acid and dimethylvinyl is used tinyl hydroperoxide of the general formula 5-10% by weight of the monomer and mixing is carried out by the action of ultrasound. 1249024 A1