SU1235501A1 - Bylite tablets - Google Patents

Description

The invention relates to the pharmaceutical industry, namely the creation of xylitol tablets used in the treatment of diabetes mellitus as a food product instead of sugar.

The aim of the invention is to increase the strength and increase the storage time due to the inclusion of aerosil in the xylitol tablets at certain ratios of the components.

Xylitol tablets are made in the following manner.

In a two-channel mixer, xylitol and aerosil are mixed, the mixture is passed through a granulator and mixed with peppermint oil, and with the rest of the mixture of xylitol and aerosil, passed through a granulator, powdered with stearic acid and tableted.

Example1. In a two-chamber mixer, 95.5 xylitol and 2.0 aerosil are mixed. The semi-mixed mixture is passed through a granulator with a hole size of 2 mm. The resulting mixture is mixed with 0.1 peppermint oil, combined with the remaining part of the mixture of xylitol and aerosil, passed through a granulator with an opening size of 2 mm, powdered with stearic acid in an amount of 0.5 and tabletiruot.

Example 2. Mix 97.4 xylitol and 3.0 aerosil for 2 min n. passed through a granulator with an opening size of 2 mm.

The mixture is combined with 0.5 peppermint oil. Prepared

Fluctuations in the mass of individual tablets from a given (0.6 g) D (should be on GFH no more than 5%)

Breaking strength, N

Abrasion resistance, Z

the mass is mixed with the remaining part of the mixture of xylitol and aerosil in a two-shaft mixer for 2 minutes, after which it is passed through a granulator with

hole size 2 mm, powdered with stearic acid in an amount of 1.0 and pelletized.

The strength of the obtained tablets soy bends at least 29 N for fracture, and

for abrasion not less than 99% with a decomposition rate of 9-10 minutes with a shelf life of tablets in the appropriate package for 2 years.

Known tablets cannot be made on an automatic tablet press, since the tablet mass does not have the required flowability, it clogs up, hangs in the feeder hopper and

There is no uniform weight change in the matrix. All this does not provide accurate dosing of the mass and the required quality of the tablets. It is possible to press T1 elko about 15 tablets, and

then the mass enters the matrix - freezes. The last 4-5 tablets, when ejected from the matrix, are immediately crushed51. The mass of the remaining tablets ranges from 0.500 to 0.366 g.

Data on the quality of the proposed tablets in comparison with the known are given in table. one.

, ...

Characteristics of the course of pressing

and quality of tablets depending on the quantitative ratio, g%, ingredients and xylitol tablets

is given in table. 2

Table 1

16.66-39 O

ABOUT

Break down and crumble

Disintegration time (should be GFH not more than 15 minutes)

Shelf life

Continuation of table 1

9-10 min

20-30 s

3 years in accordance- Do not look for packaging. In order to protect the mills from flying away, the tablets should be packaged in one of the following packages: server type; from aluminum printed and varnished foil: aluminum twist-type packaging for tablets is chill; glass bottles with cork and polyethylene screw cap

Claims (1)

XYLITE TABLETS containing xylitol, peppermint oil, stearic acid or its derivatives, characterized in that, in order to increase strength and increase shelf life, they additionally contain aerosil in the following ratio of components, g Z: Xylitol 95.5-97.4 Peppermint Oil 0.1-0.5 Stearic acid 0.5-1.0 Aerosil 2.0-3.0>