SU1197643A1 - Method of determining the indications to autodermotransplantation in case of patient's burns - Google Patents

Abstract

METHOD FOR DETERMINING THE INDICATIONS OF AUTODERMO TRANSPLANTATION WITH PAL-DIENT BURNS by examining prior to transplantation of peripheral blood lymphocytes, characterized in that, in order to improve the accuracy of prediction and prevention of transplant lysis, in the population of lymphocytes under study, the number of active T-screenings and prevention of lysis of the graft is determined, the number of active T-programs in the lymphocytes under investigation is determined by the number of active T-programs in the lymphocytes of the transplant, in a population of studied lymphocytes -Lymphocytes, forming sockets with outrerythrocytes, and when the value of these indicators is within the normal range, the engraftment of the graft is predicted, and when they increase by comparison With a rate of more than 2 times, prediction of lysis of the transplant is predicted.

Description

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The invention relates to medicine, namely to transplantation, and can be used in the treatment of burned patients.

The aim of the invention is to improve the accuracy of prediction and prevention of lysis of the graft.

Example 1. Freestyle M., Diagnosis: burn disease. Burn burn boil 30% / P1B top of neck, back, growth areas. 6 weeks after the burn, the wounds were fully prepared for plastic surgery. Before the operation, the indicators of cellular immunity are determined in the blood of the number of active T-lymphocytes, stable T-lymphocytes and T-lymphocytes forming sockets with auto-erythrocytes (Table 1). These figures exceed average normal values. in 2, 7.3 and in | 10.6 times, respectively. 12 days after plasty, the graft is completely rejected.

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Strengthen immunosuppressive therapy. The indicators of cellular immunity are normalized (Table 1). After repeated autodermoplasty, the skin grafts have taken root completely.

Example 2. Patient L.. Diagnosis: burn disease. Burn flame 28% / CV. jcT.Hor. Burn exhaustion. 8 weeks after the burn

wounds were prepared for plastic. Before the operation, the number of active T-lymphocytes, stable T-lymphocytes and T-lymphocytes forming sockets with autoerythrocyte cells is determined in the patient’s blood count. At the same time, all three indicators are within physiological fluctuations (Table 1). Performed autodermoplastika. The transplant has survived completely.

Dependence of the outcome of autodermo plastics on the cellular immunity parameters in pre-burned tabular I.

Table 1

22

56

Sick M.

5 3

34 25

22-39

0-6

DP proofs of the effectiveness of the invention before the operation of autodermoplastika study the indicators of cellular and humoral immunity in 35 burnt males aged 18 to 52 years with an area of deep (SB-iy) burn from 7 to 35% of the body surface (Table 2).

Wounds are fully prepared for plastic in 4-8 weeks from the moment

sixteen

Transplant lysis

Engraftment graft engraftment graft

burns All patients receive treatment for corticosteroids commonly used for burn disease (prednisone 15-20 mg / day). The outcome of transplantation is estimated at 4-15 days.

Indicators of T-and B-systems of immunity in healthy people and burned are presented in table 2.

- Statistically, it is believed (R 0.01) by comparison with eorm.

table 2

Claims (1)

METHOD FOR DETERMINING INDICATIONS FOR AUTOMODERMOTRANSPLANTATION AT BURNING OF PATIENTS by examining peripheral blood lymphocytes before transplantation, which is distinguished by the fact that, in order to increase the accuracy of prognosis and prevention of transplant lysis, the number of active T-lymphocytes ^ stable T-lymphocytes and T-lymphocytes forming rosettes in the population of the studied lymphocytes is determined with autoerythrocytes, and with the value of these indicators within the normal range, graft engraftment is predicted, and with an increase of more than 2 times the normal rate, graft lysis is predicted. WITH • m <55> 1197643 2