SU1176248A1 - Method of simulating thermoreceptor operation - Google Patents
Method of simulating thermoreceptor operation Download PDFInfo
- Publication number
- SU1176248A1 SU1176248A1 SU813361436A SU3361436A SU1176248A1 SU 1176248 A1 SU1176248 A1 SU 1176248A1 SU 813361436 A SU813361436 A SU 813361436A SU 3361436 A SU3361436 A SU 3361436A SU 1176248 A1 SU1176248 A1 SU 1176248A1
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- SU
- USSR - Soviet Union
- Prior art keywords
- thermoreceptor
- changing
- state
- aggregation
- simulating
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- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
СПОСОБ МОДЕЛИРОВАНИЯ РАБОТЫ ТЕРМОРЕЦЕПТОРА путем изменени проводимости вещества, способного измен ть агрегатное состо ние под действием температуры, отличающийс тем, что, с целью приближени модели к физиологическим усло-ви м и расширени диапазона исследуемых температур, из вещества, измен ющего агрегатное состо ние, формируют бимолекул рную плоскую мембрану, помещенную в буферный раствор с рН 3,2-8,0.A METHOD FOR MODELING THE WORK OF A THERMORECEPTOR by changing the conductivity of a substance capable of changing the state of aggregation under the influence of temperature, characterized in that, in order to bring the model to the physiological conditions and expand the range of temperatures under study, the substance that changes the state of aggregation forms bimolecular flat membrane, placed in a buffer solution with a pH of 3.2-8.0.
Description
Изобретение относитс к физикохимической биологии и ь4едицине (направлено на моделирование проблем . регулировани биологических функций) а также к бионике и может быть ис- 5 пользовано в различных област х техники в качестве термореле и точечного термометра.The invention relates to physicochemical biology and human medicine (aimed at modeling problems. Regulating biological functions) as well as to bionics and can be used in various areas of technology as a thermal switch and a point thermometer.
Целью изобретени вл етс приближение модели к физиологическим Ю услови м и расширение диапазона исследуемых температур.The aim of the invention is to approximate the model to physiological conditions and extend the range of temperatures studied.
На чертеже представлено устройство дл осуществлени предлагаемого спюсоба.15The drawing shows a device for carrying out the proposed pulley.
Способ осуществл ют следун дим образом .The method is carried out in the following way.
В кювету 1, выполненную из диэлектрического материала (тефлон, стекло и т.п.), помещаетс тефлонова кюве- 20 та 2, в отверстии которой (площадь отверсти 1 мм) формируетс бимолекул рна мембрана 3. Обе кюветы заполн ютс водным раствором электролита 4. Электрическое сопротивле- 25 ние мембраны измер етс с помощью измерительных непол ризующихс электродов 5, опущенных в раствор электролита по обе стороны .мембраны, устройство снабжено завинчивающейс крьшкой 6. Выходной сигнал непрерьгано регистрируетс на ленте самопишущего потенциометра.In a cuvette 1 made of a dielectric material (Teflon, glass, etc.), a Teflon cuvette 2 is placed, in the opening of which (a hole area of 1 mm) a bimolecular membrane 3 is formed. Both cells are filled with an aqueous electrolyte solution 4 The electrical resistance of the membrane 25 is measured by measuring non-trimming electrodes 5, which are lowered into the electrolyte solution on both sides of the membrane, and the device is equipped with a screw-on cap 6. The output signal is continuously recorded on a self-recording potentiometer tape. but.
Раствор дл формировани бимолекул рных липидных мембран содержит индивидуальные химически синтезированные фосфолипиды в смеси хлороформ, метанол, декан.в объемном соотношении 2:1:7 в концентрации 10 мг/мл. Дл исследовани достаточно 0,001 мл раствора лшгада.The solution for the formation of bimolecular lipid membranes contains individual chemically synthesized phospholipids in a mixture of chloroform, methanol, decane, in a volume ratio of 2: 1: 7 at a concentration of 10 mg / ml. 0.001 ml of a liquid solution is sufficient for research.
Работа модели терморецептора осуществл етс следующим образом. The operation of the thermoreceptor model is carried out as follows.
После отвинчивани крьшгки отверстие тефлоновой кюветы смазьшают раствором липида. Затем стекл нную и тефлоновую кюветы заполн ют раствором электролита с определенным значением рН. В раствор около отверсти тефлоновой кюветы вьщувают пипеткой с остатками липида пузырек воздуха. На отверстии образуетс бимолекул рна липидна мембрана. Крьшпса завинчиваетс , и устройство помещаетс в среду, температуру которого необходимо измерить.After unscrewing the cap, the hole in the Teflon cell is smeared with a lipid solution. The glass and Teflon cells are then filled with an electrolyte solution with a specific pH value. An air bubble is pipetted with lipid residues into the solution near the hole in the Teflon cell. A bimolecular lipid membrane is formed at the opening. The caps are screwed down and the device is placed on the medium whose temperature is to be measured.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU813361436A SU1176248A1 (en) | 1981-11-27 | 1981-11-27 | Method of simulating thermoreceptor operation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU813361436A SU1176248A1 (en) | 1981-11-27 | 1981-11-27 | Method of simulating thermoreceptor operation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1176248A1 true SU1176248A1 (en) | 1985-08-30 |
Family
ID=20985123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU813361436A SU1176248A1 (en) | 1981-11-27 | 1981-11-27 | Method of simulating thermoreceptor operation |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1176248A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105679151A (en) * | 2016-03-31 | 2016-06-15 | 济南大学 | Novel electrolyte solution experimental device |
-
1981
- 1981-11-27 SU SU813361436A patent/SU1176248A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Авторское свидетельство СССР № 456158, кл. G 01 К 1/00, 1973. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105679151A (en) * | 2016-03-31 | 2016-06-15 | 济南大学 | Novel electrolyte solution experimental device |
| CN105679151B (en) * | 2016-03-31 | 2018-03-27 | 济南大学 | A kind of new electrolytic solution experimental provision |
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