SU110575A1 - Method for producing acetoacetyl derivatives of carboxylic acid amides - Google Patents
Method for producing acetoacetyl derivatives of carboxylic acid amidesInfo
- Publication number
- SU110575A1 SU110575A1 SU553258A SU553258A SU110575A1 SU 110575 A1 SU110575 A1 SU 110575A1 SU 553258 A SU553258 A SU 553258A SU 553258 A SU553258 A SU 553258A SU 110575 A1 SU110575 A1 SU 110575A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- carboxylic acid
- acid amides
- derivatives
- acetoacetyl derivatives
- producing acetoacetyl
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Ацетоацетильные производные амидов карбоновых кислот получаютс взаимодействием хлорангидридов карбоиовых кислот с амидом ацетоуксусной кислоты.Acetoacetyl derivatives of carboxylic acid amides are obtained by reacting carboxylic acid chlorides with acetoacetic acid amide.
Предлагаемый способ позвол ет получить те же вепхества из другого вида сырь : дикетеиа и амида карбоновой кислоты. Реакцию ацилировани амида дикетеном провод т в присутствии основных катализаторов, например, пиридина, триэтиламина.The proposed method allows to obtain the same quantities from another type of raw material: diketia and carboxylic acid amide. The amide acylation reaction with diketene is carried out in the presence of basic catalysts, for example, pyridine, triethylamine.
Пример 1. Смесь 5 г амида бензойной кислоты, 4 г дикетена и 20 мл бензола кип т т до полного растворени амида (5-10 мин.), охлаждают раствор до 60°, добавл ют три капли пиридина и снова кип т т до исчезновени запаха дикетена (20- 30 мин.). После охлаждени раствора выпадает осадок N-ацетоацетилбензамида , который отфильтровывают . Выход 3,7 г (43% от теоретического ); т. пл. 125° (из этанола).Example 1. A mixture of 5 g of benzoic acid amide, 4 g of diketene and 20 ml of benzene is boiled until the amide is completely dissolved (5-10 minutes), the solution is cooled to 60 °, three drops of pyridine are added and again boiled until disappear diketen odor (20-30 min.). After cooling the solution, N-acetoacetyl benzamide precipitates, which is filtered off. Yield 3.7 g (43% of theoretical); m.p. 125 ° (from ethanol).
Пример 2. Смесь 3,8 г дикетена, 8 с амида дифенилуксусной кислоты, шесть капель П1ф 1дина и 30 M.I дихлорэтана нагревают 1 час на кип щей вод ной бане. Растворитель отгон ют . Остаток перекристаллизовывают .Example 2. A mixture of 3.8 g of diketene, 8 with diphenylacetic acid amide, six drops of P1F 1Din and 30 M.I of dichloroethane is heated for 1 hour in a boiling water bath. The solvent is distilled off. The residue is recrystallized.
Х-ацетоацетилдифепилВыход 6,4 г (57% от теоретичеацстамида пл. 142,5-143° (из этаского ); т. нола).X-acetoacetyldiphapil Exit 6.4 g (57% of the theoretical acetamide melting point 142.5-143 ° (from ethanol); t. Zola).
Предмет изобретени Subject invention
Способ получени ацетоацетильных производных амидов карбоновых кислот, о т л и ч а ю HI и и с тем, что дикетеном действуют на амид соответствующей карбоновой кислоты в присутствип основных катализаторов (например, пиридина, трнэтиламина).The method of obtaining acetoacetyl derivatives of amides of carboxylic acids, tl and h and HI and the fact that diketenom act on the amide of the corresponding carboxylic acid in the presence of basic catalysts (for example, pyridine, trnethylamine).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU553258A SU110575A1 (en) | 1956-06-11 | 1956-06-11 | Method for producing acetoacetyl derivatives of carboxylic acid amides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU553258A SU110575A1 (en) | 1956-06-11 | 1956-06-11 | Method for producing acetoacetyl derivatives of carboxylic acid amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU110575A1 true SU110575A1 (en) | 1956-11-30 |
Family
ID=48383280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU553258A SU110575A1 (en) | 1956-06-11 | 1956-06-11 | Method for producing acetoacetyl derivatives of carboxylic acid amides |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU110575A1 (en) |
-
1956
- 1956-06-11 SU SU553258A patent/SU110575A1/en active
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