SU1098944A1 - Bactericidal and fungicidal composition based on polyvinyl chloride - Google Patents

Description

The invention relates to the chemical industry, in particular, to bactericidal and fungus-resistant polyvinyl chloride (PVC) materials used in various districts of the national economy, and can be used for the manufacture of medical products with a bicidal and fungicidal effect, as well as for the production of other mushroom-resistant materials and products. For most materials used in medical technology, the requirements are resistance to mold and fungi, as well as the ability to suppress the action of some bacteria (bactericidal). A known method for producing such materials, which is carried out by introducing into their composition compounds having fungicidal and b-antericidal action (biocides) G J However, the use of biocides in a PVC material, as a rule, leads to a deterioration of its physicomechanical and processing properties, as well as reducing thermal stability 2. Therefore, it is a very important task to use such compounds that would not impair the physicomechanical and processing properties of the known mushroom-resistant composition containing 100 wt.h. PVC 4570 mach. ester plasticizer, 6.5-13.2 ma.ch. lead stabilizer and 0.05-3.0 mach. fungicide supplement - dichloro ethylene-1-2-bis (dimethyl carbodoxy-dimethyl) ammonium (etonium) 3j. The above composition has a high specific volume electrical resistance, is resistant to mold fungi (the material does not grow over Fri; with fungi over 120 eut) , has bactericidal properties of the radius of the zone of growth of bacteria (Rj) mm}: etafilokkok (St.) - 3-5J E. coli (E. coli) - 2, blue-green pus bacillus (PyocJ - 1. Thermostability of the composition is high: T 250 min. However, tsfmoostability is achieved by the introduction of the PV X-materials as thermostabilizers of lead salts, which, due to the toxicity of HP, can be used to produce medical devices.Gels are applied to etonium as part of a non-toxic medical system, where calcium and zinc stearates are used as thermostabilizers, the thermal stability of the composition will be only low. that the composition will not be able to be processed into products, since etonium greatly reduces the thermal stability of PVC, which is the closest in terms of the number of features and effect achieved to the invention is a PVC-based bactericidal fungicidal composition, containing on 100 m.h., PVC 30-70.ha.h., ester plasticizer, 1-3.ha.h. stabilizer and 0.01, -0.1 ma.ch. a bactericidal and fungicidal additive — cetylpyridinium chloride (CPH) or cetypyridinium bromide PPB. The composition has a high fungal resistance (the time before the onset of the lesion is 120 days and some bactericidal activity: (Rj St - 5; E.Coli - 2, Ruye - 1). is 7080 minutes 4. The aim of the invention is to improve the bactericidal activity and thermo-stability of the PVC compositions while maintaining its mushroom resistance. To achieve this goal, the bactericidal and fungicidal composition on oenovo PVC contains organic ester Novel plaetifier and bactericidal and fungicidal additive as a mixture of salts of metals of group II with 6-benzole sulfamidehekean and 6-benzoyl amide hekean kieloth contains the following ratio of composition components, by weight. 1-3.0 The metal salt of the tl group is 6-benzoyl-amide-heichean kiellota 0.1-3.0 The plasticizer as a plasticizer contains dioactyl phthalate (DOP1, dioctyl ebaccinate (DOS), dioctyl adipate (DOA), didodecyl phthalate (DDC), and t. . The composition may additionally contain other specific additives: niokeidants, chemicals, pigments, etc. The use of the proposed ethereal salts of these kielots I10) allows to obtain the bactericidal properties and thermal stability of the plasma-based composition based on PVC while maintaining its fungus resistance. The proposed mixture has a synergistic bactericidal action, i.e. a mixture of metal salts of benzenesulfamidohexanoic acid in an amount of 0.1-3.0 wt.h. and benzoylamido444 hexanoic acid in the amount of 0, t3, 0 wt.h. gives such an effect on bactericidal activity, which is 2 times greater than the effect on bactericidal action when using each of these acids individually in the same amount as their mixture. "The composition and bactericidal properties of PVC composition are given in Table 1. Table 1

100

PVC

one.

thirty

0.2 0.2 Compositions for comparison

100, 30 1 1

Compositions for comparison

100

PVC

five.

Offered

17

eight

.3

8 Offered

ten

20

thirty

Dof

Saba

100

6

pvc

ten

Dof

ZnCA

Ca is a salt of 6-benzoylamidohexanoic acid;

f4, Zn - salt of 6-benzenesulfamidohexanoic acid The synergistic effect of bactericidal activity from the introduction of a mixture of metal salts of 6-benzenesulfamidohexanoic and 6-benzoyl amide hexanoic acids is shown by the example of two PVC compositions. Similar results were obtained when using a mixture of these salts in the composition of other proposed compositions. Example 1. In the mixer for 45 minutes (the rotation speed of the stirrer is 950 rpm), 100 mas.h; PVC; 30 ma.ch. DOP; 0.3 ma.ch. SABA 0.3 ma.ch. ZnCA. The resulting composition is rolled at 150 ° C for 7 minutes, pressed at 160 ° C for 3 minutes under a pressure of 120 kg / cm. Test specimens are prepared from the obtained film. The bactericidal activity of the samples is determined as follows: circles (d 7 mm) are cut out of a 1 mm thick film which are placed on a solid nutrient mixture in a petri dish. Then, the nutrient medium together with the sample is contaminated with the bacteria: staphylococcus (51), intestinal bacteria.

100

PVC 30

Dof

Continued t bl, 1

ten

10 sticks (E.Coli) and sticks of blue-green pus (Ruos). Bactericidal properties are estimated by the radius (in mm) of the zone of growth inhibition of microorganisms (ksz) around the sample, which is formed after holding the sample for 24 hours at 37 C. The fungus resistance of the samples is determined according to GOST 9.049-75 using method B. The test sample is held in the environment of mold fungi of the following t / GG species: R. funiculosumv A. niger. Tr. yiride; A. flavus. The time until the specimen begins to overgrow with the mold is then determined. At the same time, the longer the sample does not grow, the more fungus-resistant it is. The thermal stability of the films is determined in accordance with GOST 14041-68 at 175 ° C. Examples 2-15. The method of preparation and test methods for mosquitoes in Example 1. The composition and properties of the PVC compositions are given in Table. 2. Examples 16-23 (for comparison). table 2

17

17

15

25

sixteen

Continued table. 2

140

130

130

130

80

120

190

130

ten

15

110

130

17

17

17

15

18

15

120

160

135

130

145

140

6120

130

130

100

ten

140

120

13

eight,

pvc

100

Dos

10 Sava

0.3

ZnCA

0.3

17

9,

PVC 100

Dos

100

SAVA 0.3

ZnCA 0.3

14

Famous

No growth delay zone

5 2 1 Compositions for comparison

PVC

100 DOF 30 0.05 CACA ZnBA 0.05

five .

1098944

14. Plea tal blo.

130

100

130

135

50

60

120

50

120

thirty

Get quality films

12

14

Growth delay zone

No growth delay zone

Continued table. 2

Thermal stability, min fails

130

50

140

60

Negro is out

120 racks

Negribo100 racks From the table. 2 Fidano data that PVC compositions containing bent benzylsulfonamide dohexanoic acid (O, 1-3 and parts) and 6-benzoylamidohexanoic acid (0.1–3 parts by weight) containing “K e” with muds of metals of group II and 0.1-wt. Parts high bactericidal effect Radius of bacterial growth zone mm: St.15-20j E.Coli 7-15J Ruos 5-10 (Table 2, examples 1-19), which significantly exceeds the bactericidal properties of the known composition: St 5; E.Coli 2; Ruos 2, (tab. 2, examples 20-21). The proposed composition is a fungal bone; mold fungi occur in 120–160 days (Table 2, examples 1–19), while in the HZ: BeSt composition over 50120 CU (table examples 20–21). KptiMe addition, the proposed composition has a high thermal stability; the time before the occurrence of hydrogen chloride is 80-190 min (Table 2, examples 1-19), while the known composition is only 50-60 min (Table 2, examples 20-21). When the mixture of BA and CA salts in the PVC composition is lower in quantities than the proposed bactericidal properties, the thermal stability of the composition is also practically not observed (Table 2, Example 22). When using a mixture of BA and CA salts in amounts exceeding the limits proposed, low-quality films or with reduced thermal stability are obtained from the composition (Tables examples 23-25). The use of commonly used t & stabilizers — CAZn or Ba-Cd stearates — provides compositions that are thermally stable, but not fungus-resistant and bactericidal (Table 2, Examples 26-27). A mixture of salts of metals of group II 6-benzenesulfonamide and 6-benzoylamidohexanoic acids can be used in the composition of bactericidal and fungus-resistant PVC composition without conventional PVC heat stabilizers (metal stearates), since these salts have the properties of heat stabilizers. In addition, the proposed blend significantly reduces the melt viscosity of the composition, which facilitates the processing of the material. Thus, it is proposed to introduce into the PVC material a mixture of compounds that have a universal effect: bactericidal, fungicidal, stabilizing. The proposed composition is mainly intended for the production of medical devices having a bactericidal effect. Currently used in medical applications composition for medical purposes, containing 100 mash. PVC 70 mach. Dioctyl phthalate, 1 mph. calcium stearate, 1 mah. zinc stearate, 3 ma.ch. epoqueed maela, 0.5 ma.ch. phosphite. The material based on this composition is non-toxic and has a satisfactory thermal stability (100 min). Replacing this composition with the proposed one will make it possible to impart bactericidal and fungicidal properties to the composition, as well as increase its laboratory stability.

Claims (1)

BACTERICID-FUNGICIDAL COMPOSITION BASED ON POLYVINYL CHLORIDE, containing ester plasticizer τόρ and a bactericidal-fungicidal additive, characterized in that, in order to improve the bactericidal activity and thermostability of the composition while maintaining its fungus resistance, it contains a bactericidal-metal-fungicidal mixture; fishing of group II of 6-benzenesulfamidohexanoic and 6-benzoylamidohexanoic acids in the following ratio of components, parts by weight: Polyvinyl chloride Ester plasticizer Group I metal salt of 6-benzenesulfamidohexanoic acid Group II metal salt of 6-benzoylamidohexanoic acid SU ... 1098944