SU1088727A1 - Method of preserving perfumery and cosmetic articles as well as household chemical goods - Google Patents

Abstract

METHOD FOR PRESERVATION PARFSHERNO and cosmetic products and household chemical goods by Evedeni composition containing a preservative and a synergist, characterized in that, in order povsheni antimicrobial effect of the preservative and reducing the concentration of the latter, as a synergist used oksietilydendifosfonovuyu acid, and to honors preservative - substance Formalin, nipazol, ninagin and srrbinova, dairy, benzoic and acetylsalicylic acid, selected from the range, with each of the components taken in an amount of 0.0625-0.125% of 3 mass canned product.

Description

The invention relates to a method for preserving perfumes and cosmetics, household chemicals and for them with two-component mixtures. The microbiological stability of perfumery cosmetics, household and household preparations based on protein raw materials is required by introducing chemical preservatives into the composition. There are also cases of the development of gram-negative bacteria in an environment where there is no protein, but only anionic surfactants are present. The problem of preventing shampoos, lotions and creams from being contaminated with tanks. The fungi and fungi have become even more urgent. This is explained by the fact that traditional preservatives in this area have some toxicological and sensitizing effects when used in relatively large amounts (from 0.5 to 1%). Any compound can be used as a preservative, showing antimicrobial activity. However, in preparations intended for use in everyday life, only such preservatives can be tolerated that do not pose a danger to human health. Common preservatives are table salt, vinegar, wine, and lactic acid. These substances are widely used in the preservation of food protein products. For the preservation of technical products, aromatic acids and their derivatives, phenols, aldehydes, and halide derivatives are recommended. compounds and some other things. As a rule, they are all applied individually. The scientific, technical, and patent literature contains descriptions of two-component systems of preservatives. In a number of cases there is a synergism of antimicrobial action in their use. There is a known method of preserving perfumes and cosmetics and household products by introducing a composition containing a preservative n synergist lj. However, according to a known method, the preservative is used within certain limits, and in this case it has some toxicological and sensitizing effects. In smaller quantities, they are ineffective # 1I, without providing the necessary microbiological activity. The purpose of the invention is to increase the antimicrobial effect of the preservative and reduce the concentration of the latter. The goal is achieved by the fact that according to the method of preserving perfumery and cosmetic products and household chemicals by introducing a composition containing a preservative and synergist, hydroxyethylidene diphosphonic acid is used as a synergist, and a preservative is a substance selected from a number of formalin, nipazol, nipagin and sorbinrva, dairy, benzoic and acetylsalicylic acid, with each of the components taken in the amount of 0.0625-0.125% by weight of the preserved product. Hydroxyethylidene diphosphonic acid (HEDP) exhibits a pronounced synergism of antimicrobial action. HEDP has the following formula: HE It It 0 p-Cp-0 (11 It CH3SON All components of the preservative residues are manufactured in the industrial scale and are readily available and products. The results of the efficacy study are individual: and the two-component preservatives are tabulated.

Formalin

0.125

0.05

0.01

+ - +

Nipazole

0.25

.

0.125 0.05

+ +

-f

ъ

+ + +

Nipagin

-.-- "- 4- - + + Sorbic Acid

 ++ +

- - + +

+ + Lactic acid

+ + Benzoic acid

+ -f + +

+ -f

+ +

+ +

+ +

Christmas Candle

Concepter 1,

I

. X.

Duration awn

iMftC

Eney

b carried

12mei

ZDMA

Acetylsalicylic acid

..- - -. - - - - + + - -. + +

ylidenediphosphonic acid

- .- - -.

Formalin + HEDP

- - --- - -.

- - - - - - -

Nipazol + HEDP

- ------ - - - --------- - - Sorbic acid + HEDP

- -------- -,

Lactic acid + HEDP

--------- +

Benzoic acid + HEDP -------- --- ++ - +

Nipagin + HEDP

 - - - - - - ------ - - Acetylsalicylic acid + HEDP - -------- - -

- ------ -Prime and E. (+) - crop growth is observed.

Table continuation

Staphylococcus aureus

T

3 me1 6

12 months

1 her

carried crops, (-) - no growth. According to the data presented in the table, HEDP itself does not have antimicrobial activity at least up to 1% concentration. At the same time, its additives to preservatives dramatically enhance the effects of the latter. The threshold concentration of this grinder for individual preservatives is almost an order of magnitude lower. The effectiveness of preservatives was evaluated in relation to the vegetative forms of E. coli bacteria (E. coli) to St. aureus (Staphylococcus aureus by known methods. As a nutrient medium most favorable for the development of bacterial processes, a 10% aqueous solution of casein hydrolyzate with a molecular weight of 500 700 was selected. To determine the threshold concentrations, preservative solutions with different contents are prepared active in a substance4 in protein hydrolyzate. The antimicrobial effect of preservatives is evaluated by the method of disinfection of infected test objects when immersed in the test solutions. Bacterial suspensions are prepared from 18-24 hour cultures. The pH value of the solutions is assumed to be 7, corresponding to the protein components in which the protein components are mainly injected.In contrast to the common substances in the study of the bactericidal properties of new substances, the period of observation over the samples of hydrolyzates containing preservatives is longer. exclude samples that visually mark the growth of crops.At the end of the month, the remaining samples are again infected with cultures of Escherichia coli and Staphylococcus aureus. With the growth of cultures on the third day after infection, it is concluded that the substance has lost antimicrobial properties, which may be a result of any interaction of the preservative with the medium, resulting in inactivation of the introduced substance. All test tubes with a hydrolyzate of a known concentration were monitored for six months. I individual samples — within a year. Repeated infections were carried out after 1, 3, and 6 months. after the start of the experiment. The threshold is considered the minimum concentration of preservative, at which the development of vegetative cultures of E. coli and St. is not noted. aureus for all time observations. Example. 1. In a 500 ml glass beaker with a capacity of 500 ml, 199.5 g of a freshly prepared Selene washing agent, containing no preservative (OST-615-650-72), 0.31 P- 40% formalin solution (0.0625% in in terms of 100% formalin) and 0.125 g of HEDP (0.0625). The beaker is placed in a thermostated water bath. The contents of the beaker are stirred at 55-6 CGS for 8-10 minutes until the suspensions completely dissolve. The mixture is then cooled to room temperature and poured into a 200 ml bottle with a capacity of 200 ml. Screw out the bottle with a crush. The product, without any signs of microbiological decomposition, is stable when stored under normal conditions for a year. Example 2. Place the system prepared in Example 1 and put it in 199 , 7 g of Selenium, O, 125 g of nipazol (0.0625%) and 0.125 g of HEDP (0.0625%). The tool is stable throughout the year. Example 3. In the system described in example 1, placed 199 g of Selenium, 0.125 g of nipagin (0.0625%) and 0.125 g of HEDP (0.0625%). The product is stable for a year., Example 4. In the system described in example 1, 199.5 g of selenium agent, 0.250 g of sorbic acid (0.125%) and 0.250 g of HEDP (0.125%) are placed. The tool is stable throughout the year. Example 5. In the system described in Example 1, 199.13 g of selenium agent, 0.62 g of 40% lactic acid (0.125% based on 100% acid) and 0.250 g of HEDP (0.125%) are placed. The tool is stable throughout the year. Example 6. In the system described in Example 1, 199.13 g of selenium, 0.250 g of benzoic acid (0.125%) and 0.250 g of HEDP (0.12%) are placed. The tool is stable throughout the year. Example 7. In the system described in Example 1, 199.75 g of selenium agent, 0.1.25 g of acetylsalicylic acid (0.0625%) and 0.12-5 g of HEDP (0.0625%) are placed. Means Stable throughout the year. example 8. In the system described in example 1, placed 199.56 g of protein hydrolyzate (TU17-RSFSR 12-38-139-77), 0.31 g of 40% formalin solution (0.0625% based on 100% formalin) and 0.125 HEDP (0.0625%). The product is stable throughout the year. Example 9. In the system described in example 1, 199.7 g of protein hydrolyzate, 0.125 g of nipazol (0.0625%) and 0.125 g of HEDP (0.0625%) are placed. The product is stable throughout the year. , Example 10. In the system described in Leamer 1, 199.7 protein hydrolyzate, 0.125 g nipine (0.0625%) and 0.125 g HEDP (0.0625%) are placed. The product is stable throughout the year. Example 11. In the system described in Example 1, 199.5 g of protein hydrolyzate, 0.250 g of sorbate acid (0.125%) and 0.250 g of HEDP (0.125%) are placed. The product is stable throughout the year. Example 12. In the system described in example 1, put 199.13 protein hydrolyzate, 0.62 g of 40% lactic acid (0.125% based on 100% acid) and 0.250 g of HEDP (.0.125%). The product is stable for a year. 27.10 Example 13. In the system described in example 1, 199.5 g of protein hydrolyzate, 0.250 g of benzoic acid (0.125%) and 0.250 g of HEDP (0.125%) are placed. The product is stable throughout the year. Example 14. In the system described in example 1, put 199.75 g of protein hydrolyzate, 0.125 g of acetylsalicylic acid (0.0625%) and 0.125 g of HEDP (0.0625%). The product is stable throughout the year. As can be seen from the table above, the use of a two-component preservative-HEDP system is much more effective than an individual preservative. HEDP is a harmless substance with a set of healing properties. This complex is already used in the whole range of perfumery and cosmetic products due to some of its other properties. At the same time, preservatives such as benzoic acid, formalin, nipazol cannot be considered absolutely harmless to the human body. Their use in household products is strictly limited. Thus, the invention will allow to drastically reduce the concentration of preservatives in cosmetic and household preparations, to reduce, respectively, their cost, and most importantly - to make them harmless to humans.

Claims (1)

METHOD FOR CONSERVATION OF PERFUMERY-COSMETIC PRODUCTS AND GOODS _v HOUSEHOLD CHEMISTRY by introducing a composition containing a preservative and a synergist, characterized in that, in order to increase the antimicrobial effect of the preservative and lower the concentration of the latter, the substance is used as a synergist, the preservative is an oxyethylidendantif selected from a number of formalin, nipazole, nipagin and sorbic, lactic, benzoic and acetylsalicylic acids, with each of the components being taken in an amount of 0.0625-0.125% by weight of canned food the product to be violated.