SMT201500264B - Mutanti della frataxina - Google Patents
Mutanti della frataxinaInfo
- Publication number
- SMT201500264B SMT201500264B SM201500264T SM201500264T SMT201500264B SM T201500264 B SMT201500264 B SM T201500264B SM 201500264 T SM201500264 T SM 201500264T SM 201500264 T SM201500264 T SM 201500264T SM T201500264 B SMT201500264 B SM T201500264B
- Authority
- SM
- San Marino
- Prior art keywords
- frataxina
- mutants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0091—Oxidoreductases (1.) oxidizing metal ions (1.16)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y116/00—Oxidoreductases oxidizing metal ions (1.16)
- C12Y116/03—Oxidoreductases oxidizing metal ions (1.16) with oxygen as acceptor (1.16.3)
- C12Y116/03001—Ferroxidase (1.16.3.1), i.e. ceruloplasmin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36857610P | 2010-07-28 | 2010-07-28 | |
| PCT/IB2011/002511 WO2012014083A2 (en) | 2010-07-28 | 2011-07-27 | Frataxin mutants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201500264B true SMT201500264B (it) | 2016-01-08 |
Family
ID=45044630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201500264T SMT201500264B (it) | 2010-07-28 | 2015-10-27 | Mutanti della frataxina |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9217019B2 (it) |
| EP (2) | EP2598525B1 (it) |
| CA (1) | CA2806303C (it) |
| DK (1) | DK2598525T3 (it) |
| ES (1) | ES2552456T3 (it) |
| HR (1) | HRP20151238T1 (it) |
| HU (1) | HUE028111T2 (it) |
| PL (1) | PL2598525T3 (it) |
| PT (1) | PT2598525E (it) |
| SI (1) | SI2598525T1 (it) |
| SM (1) | SMT201500264B (it) |
| WO (1) | WO2012014083A2 (it) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10442779B2 (en) | 2014-09-22 | 2019-10-15 | Fratagene Therapeutics S.R.L. | Compositions and methods for treating Friedreich's ataxia |
| WO2016103223A1 (en) * | 2014-12-23 | 2016-06-30 | Fratagene Therapeutics Ltd. | Methods of treating friedreich's ataxia using src inhibitors |
| WO2016115503A1 (en) * | 2015-01-16 | 2016-07-21 | Voyager Therapeutics, Inc. | Central nervous system targeting polynucleotides |
| WO2017172914A1 (en) | 2016-03-30 | 2017-10-05 | Wisconsin Alumni Research Foundation | Methods and compositions for modulating frataxin expression |
| IL266358B2 (en) | 2016-11-09 | 2025-10-01 | Precigen Inc | Constructs for Prataxin Expression |
| WO2018183679A1 (en) | 2017-03-29 | 2018-10-04 | Wisconsin Alumni Research Foundation | Methods and compositions for modulating gene expression |
| US10426775B2 (en) | 2017-09-11 | 2019-10-01 | Fratagene Therapeutics Srl | Methods for treating Friedreich's ataxia with etravirine |
| AU2018338728B2 (en) | 2017-09-29 | 2025-01-02 | Centre National De La Recherche Scientifique (Cnrs) | Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery |
| EP3856762A1 (en) | 2018-09-28 | 2021-08-04 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| US20220378869A1 (en) * | 2019-07-18 | 2022-12-01 | Larimar Therapeutics, Inc. | Use of frataxin for treating leigh syndrome, french canadian type |
| WO2021021931A1 (en) | 2019-07-29 | 2021-02-04 | The Trustees Of Indiana University | Materials and methods for treating friedreich's ataxia |
| AU2020320210A1 (en) | 2019-07-29 | 2022-02-24 | Larimar Therapeutics, Inc. | Methods of quantifying frataxin and frataxin fusion proteins |
| AU2020391489A1 (en) | 2019-11-25 | 2022-06-09 | Larimar Therapeutics, Inc. | Methods for quantifying frataxin activity |
| BR112022021823A2 (pt) | 2020-04-30 | 2023-01-17 | Larimar Therapeutics Inc | Métodos para tratar doenças associadas à mielina e doenças associadas à mitocôndria |
| WO2022126029A1 (en) | 2020-12-12 | 2022-06-16 | Larimar Therapeutics, Inc. | Pharmaceutical composition comprising frataxin fusion protein and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| AT500929B1 (de) * | 2004-11-09 | 2007-03-15 | Medizinische Uni Wien Muw | Pharmazeutische zubereitung die erythropoietin enthält |
| US8703749B2 (en) * | 2009-12-07 | 2014-04-22 | Roberto Testi | Compositions and methods for treating Friedreich's Ataxia |
-
2011
- 2011-07-27 CA CA2806303A patent/CA2806303C/en not_active Expired - Fee Related
- 2011-07-27 SI SI201130654T patent/SI2598525T1/sl unknown
- 2011-07-27 HU HUE11788225A patent/HUE028111T2/en unknown
- 2011-07-27 PL PL11788225T patent/PL2598525T3/pl unknown
- 2011-07-27 ES ES11788225.8T patent/ES2552456T3/es active Active
- 2011-07-27 WO PCT/IB2011/002511 patent/WO2012014083A2/en not_active Ceased
- 2011-07-27 PT PT117882258T patent/PT2598525E/pt unknown
- 2011-07-27 HR HRP20151238TT patent/HRP20151238T1/hr unknown
- 2011-07-27 US US13/812,516 patent/US9217019B2/en not_active Expired - Fee Related
- 2011-07-27 EP EP11788225.8A patent/EP2598525B1/en not_active Not-in-force
- 2011-07-27 DK DK11788225.8T patent/DK2598525T3/da active
- 2011-07-27 EP EP15181464.7A patent/EP3012267A1/en not_active Withdrawn
-
2015
- 2015-10-27 SM SM201500264T patent/SMT201500264B/it unknown
- 2015-11-12 US US14/940,043 patent/US9944906B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2552456T3 (es) | 2015-11-30 |
| SI2598525T1 (sl) | 2016-02-29 |
| US9217019B2 (en) | 2015-12-22 |
| WO2012014083A3 (en) | 2012-04-19 |
| EP2598525B1 (en) | 2015-08-19 |
| DK2598525T3 (da) | 2015-09-21 |
| US9944906B2 (en) | 2018-04-17 |
| HUE028111T2 (en) | 2016-11-28 |
| CA2806303C (en) | 2018-01-02 |
| CA2806303A1 (en) | 2012-02-02 |
| EP2598525A2 (en) | 2013-06-05 |
| US20130196932A1 (en) | 2013-08-01 |
| PL2598525T3 (pl) | 2016-03-31 |
| WO2012014083A2 (en) | 2012-02-02 |
| HRP20151238T1 (hr) | 2015-12-18 |
| US20160060605A1 (en) | 2016-03-03 |
| EP3012267A1 (en) | 2016-04-27 |
| PT2598525E (pt) | 2015-11-02 |
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