SK98894A3 - Gassy mixture containing the nitrogen oxide for treating of pulmonal illness - Google Patents
Gassy mixture containing the nitrogen oxide for treating of pulmonal illness Download PDFInfo
- Publication number
- SK98894A3 SK98894A3 SK988-94A SK98894A SK98894A3 SK 98894 A3 SK98894 A3 SK 98894A3 SK 98894 A SK98894 A SK 98894A SK 98894 A3 SK98894 A3 SK 98894A3
- Authority
- SK
- Slovakia
- Prior art keywords
- pulmonal
- illness
- mixture containing
- treating
- nitrogen oxide
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Oblasť technikyTechnical field
Vynález sa týka plynnej zmesi obsahujúcej NO na ošetrenie pulmonálnych ochorení podía predvýznakovéj časti nároku 1.The invention relates to a gaseous mixture containing NO for the treatment of pulmonary diseases according to the preamble of claim 1.
Doterajší stav technikyBACKGROUND OF THE INVENTION
Terapia oxidom dusnatým u dospelých s adult respirátory distress syndrómom je známa. Pritom sa k pacientom s umelým dýchaním privádza s nadychovaným vzduchom eventuálne pomerne vysoká koncentrácia NO, maximálne až 60 objemových percent, z plynového zásobníka obsahujúceho niekoíko sto objemových percent NO. NO spôsobuje zníženie krvného tlaku v píúcnom obehu, nepôsobí ale na krvný tlak v celom obehu. Vzhladom k jedovatosti NO a vznikajúceho viazaného N02, tiež podmieneného umelým dýchaním a z toho vyplývajúcich malých kontrolovaných dávok NO, je pri aplikácii NO nevyhnutná veíká pozornosť.Nitric oxide therapy in adults with adult respiratory distress syndrome is known. In this case, the patient with artificial respiration is supplied with inhaled air with possibly a relatively high concentration of NO, up to a maximum of 60% by volume, from a gas reservoir containing several hundred% by volume of NO. NO causes a decrease in blood pressure in the lung circulation but does not affect blood pressure in the whole circulation. Due to the toxicity of NO and the resulting bound NO 2 , also caused by artificial respiration and the resulting small controlled doses of NO, great care is required when administering NO.
Usiluje sa o to, aby NO terapia bola tiež použiteíná u takých pacientov, ktorí dýchajú spontánne a eventuálne nie sú ošetrovaní stacionárne, aby i táto skupina pacientov mohla využívať výhody NO terapie.It is sought to ensure that NO therapy is also applicable to those patients who breathe spontaneously and eventually are not stationary so that this group of patients can also benefit from NO therapy.
Podstata vynálezuSUMMARY OF THE INVENTION
Vynález spočíva v podstate úlohy vytvoriť k tomuto účelu vhodnú plynnú zmes obsahujúcu NO, ktorá nevyžaduje zvláštnu pozornosť pri aplikácii.The object of the present invention is essentially to provide a suitable NO-containing gas mixture which does not require particular application.
Vzhíadom na predvýznakové časti uvedené v stave techniky je táto úloha podía vynálezu vyriešená znakmi uvedenými vo význakovej časti nároku 1.In view of the pre-feature parts mentioned in the prior art, this object of the invention is solved by the features set forth in the feature part of claim 1.
Výhodné ďalšie vyhotovenia vynálezu sú uvedené v závislých nárokoch.Advantageous further embodiments of the invention are set out in the dependent claims.
I ,I,
Príklady vyhotovenia vvnálezuDETAILED DESCRIPTION OF THE INVENTION
Pri praktickom použití plynnej zmesi podlá vynálezu sa táto zmieša so stopercentným lekárskym kyslíkom tak, že vzniká vdychovaný plyn pozostávajúci z 30 až 50 % kyslíka, zvyšok tvorí NO a hélium. Je pritom zaistené, že obsah kyslíka zostáva nastavený vo vnútri rozmedzia 21 až 50 %. Podiel NO je lahko nastavítelný zmeraním koncentrácie kyslíka bez toho, aby sa musela použiť meracia technika. Pri aplikácii zmesi u pacientov vzniká jedovatý NO2 v najmenšej možnej miere. Dobre sa osvedčilo použitie zmesi s 10 až 16 objemovými percentami NO v héliu.In practice, the gas mixture of the present invention is mixed with 100% medical oxygen to produce an inhaled gas of 30 to 50% oxygen, the remainder being NO and helium. It is ensured that the oxygen content remains set within the range of 21 to 50%. The NO fraction is easily adjustable by measuring the oxygen concentration without the need for a measuring technique. The application of the mixture to patients produces toxic NO 2 to the minimum extent possible. The use of a mixture with 10 to 16% by volume of NO in helium has proven to work well.
Plynná zmes obsahujúca NO a lekársky kyslík môžu byť v dvoch malých zásobníkoch, napríklad v tlakových nádobách, ktoré sú opatrené pevne nastavenou odberovou armatúrou. Takéto malé, prenosné liečebné jednotky nepotrebujú nastavovanie a kontrolu, takže môžu byť používané pacientmi doma, napríklad pri astmatických záchvatoch.The gaseous mixture containing NO and the medical oxygen may be in two small containers, for example in pressure receptacles, which are provided with a fixed sampling valve. Such small, portable treatment units do not need adjustment and control, so they can be used by patients at home, for example in asthma attacks.
Hélium má v plynnej zmesi podlá vynálezu výhodu, že môže vzhladom k svojim vlastnostiam vniknúť i do málo prevzdušnených alebo neprevzdušnených úsekov pl’úc, s akými sa stretávame u mnohých ochorení. Tým sa strháva NO a kyslík, NO spôsobuje rozšírenie priedušiek, takže sa tieto uvedené časti plúc môžu opäť zúčastniť na výmene plynov.Helium has the advantage in the gaseous mixture according to the invention that, due to its properties, it can penetrate into the low-aerated or non-aerated sections of the lungs encountered in many diseases. This causes NO and oxygen to be entrained, NO causes the bronchi to expand, so that these lung portions can again participate in the gas exchange.
Claims (2)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4327731A DE4327731C1 (en) | 1993-08-18 | 1993-08-18 | NO-containing gas mixture for the treatment of pulmonary disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK98894A3 true SK98894A3 (en) | 1995-07-11 |
Family
ID=6495447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK988-94A SK98894A3 (en) | 1993-08-18 | 1994-08-18 | Gassy mixture containing the nitrogen oxide for treating of pulmonal illness |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0639378B1 (en) |
| AT (1) | ATE197402T1 (en) |
| CZ (1) | CZ198494A3 (en) |
| DE (2) | DE4327731C1 (en) |
| HR (1) | HRP940466A2 (en) |
| HU (1) | HUT75153A (en) |
| SK (1) | SK98894A3 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
| DE19604361C2 (en) * | 1996-02-07 | 1999-01-14 | Sanol Arznei Schwarz Gmbh | Use of gas-tight primary packaging for pharmaceutical compositions |
| FR2795644B1 (en) | 1999-07-02 | 2004-07-30 | Air Liquide Sante Int | THERAPEUTIC USES OF A HELIUM / OXYGEN MIXTURE, PARTICULARLY IN THE TREATMENT OF ASTHMA |
| ES2164614B1 (en) * | 2000-09-06 | 2003-05-16 | Soc Es Carburos Metalicos Sa | HELIO AND OXYGEN MIXTURE WITH THERAPEUTIC APPLICATION. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3676563A (en) * | 1970-04-06 | 1972-07-11 | Airco Inc | Hyperbaric breathing mixture |
| SE8700977D0 (en) * | 1987-03-09 | 1987-03-09 | Olof Werner | UNIT WHICH SEPARATELY SEPARATES THE GAS CONTENT IN THE DRIVE CIRCUIT AND THE RECEIVER CIRCUIT BUT ONLY ALLOWS GAS PIPE IN THE BAD DIRECTIONS (OPEN SEPARATION) |
| SG47527A1 (en) * | 1990-12-05 | 1998-04-17 | Gen Hospital Corp | Devices for treating pulmonary vasoconstriction and asthma |
-
1993
- 1993-08-18 DE DE4327731A patent/DE4327731C1/en not_active Revoked
-
1994
- 1994-08-16 EP EP94202325A patent/EP0639378B1/en not_active Expired - Lifetime
- 1994-08-16 DE DE59409579T patent/DE59409579D1/en not_active Expired - Fee Related
- 1994-08-16 AT AT94202325T patent/ATE197402T1/en not_active IP Right Cessation
- 1994-08-17 CZ CZ941984A patent/CZ198494A3/en unknown
- 1994-08-17 HR HRP4327731.4A patent/HRP940466A2/en not_active Application Discontinuation
- 1994-08-18 SK SK988-94A patent/SK98894A3/en unknown
- 1994-08-18 HU HU9402396A patent/HUT75153A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ198494A3 (en) | 1995-03-15 |
| HU9402396D0 (en) | 1994-10-28 |
| HUT75153A (en) | 1997-04-28 |
| ATE197402T1 (en) | 2000-11-11 |
| DE4327731C1 (en) | 1994-11-10 |
| EP0639378B1 (en) | 2000-11-08 |
| DE59409579D1 (en) | 2000-12-14 |
| EP0639378A1 (en) | 1995-02-22 |
| HRP940466A2 (en) | 1996-10-31 |
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